Direct Separation of Pregabalin Enantiomers Using a Zwitterionic Chiral Selector by High Performance Liquid Chromatography Coupled to Mass Spectrometry and Ultraviolet Detection

Direct Separation of Pregabalin Enantiomers Using a Zwitterionic Chiral Selector by High Performance Liquid Chromatography Coupled to Mass Spectrometry and Ultraviolet Detection

The chromatographic resolution of pregabalin enantiomers has been often achieved by derivatization of the molecule, in order to reach enough sensitivity at low concentrations of the minor enantiomer present in the active principle. In the present article, the development and optimization of two liqu...

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Bibliographic Details
Main Authors: Lakshmi Narayana Chennuru, Thirupathi Choppari, Ramakrishna Prasad Nandula, Tong Zhang, Pilar Franco
Format: Article
Language:English
Published: MDPI AG 2016-11-01
Series:Molecules
Subjects:
pregabalin
zwitterionic selector
chiral stationary phases
direct enantiomer separation by HPLC
mass spectrometry
ultraviolet detection
method optimization
Online Access:http://www.mdpi.com/1420-3049/21/11/1578

Internet

http://www.mdpi.com/1420-3049/21/11/1578

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