Influence of PCDH9 (rs9540720) and narcissistic personality traits on the incidence of major depressive disorder in Chinese first-year university students: findings from a 2-year cohort study
Objective: The objective of this study was to explore the influence of the polymorphism of the protocadherin 9 (PCDH9) gene and the narcissistic personality trait (NPT) on the risk of major depressive disorder (MDD) in Chinese first-year university students.Methods: A 2-year cohort study was conduct...
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2023.1267972/full |
| _version_ | 1797322259692519424 |
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| author | Ruixue Xu Ruixue Xu Zhaorui Liu Hanyun Li Linlin Luo Yi Zheng Fuqin Mu Yujia Liu Weixin Zhang Ying Zhang Jianli Wang Jianli Wang Yan Liu |
| author_facet | Ruixue Xu Ruixue Xu Zhaorui Liu Hanyun Li Linlin Luo Yi Zheng Fuqin Mu Yujia Liu Weixin Zhang Ying Zhang Jianli Wang Jianli Wang Yan Liu |
| author_sort | Ruixue Xu |
| collection | DOAJ |
| description | Objective: The objective of this study was to explore the influence of the polymorphism of the protocadherin 9 (PCDH9) gene and the narcissistic personality trait (NPT) on the risk of major depressive disorder (MDD) in Chinese first-year university students.Methods: A 2-year cohort study was conducted among Chinese first-year university students who were enrolled in 2018 from two universities in Shandong Province, China. The snapshot technique was used to detect the genotypes of PCDH9 (rs9540720). The Chinese version of the Composite International Diagnostic Interview was used for the MDD assessment. The NPTs were measured by 11 items based on DSM-IV. Patient Health Questionnaire-9 and the Beck Anxiety Inventory were used to assess depressive and anxiety symptoms, respectively. Logistic regression modeling was carried out to examine the relationship between rs9540720, NPTs, and the incidence of MDD.Results: A total of 5,327 students participated in the baseline and follow-up studies and provided their blood samples. PCDH9 (rs9540720) (ORGG+GA = 2.33, 95% CI: 1.35–4.02) and NPTs (OR5–9 = 2.26, 95% CI: 1.40–3.64) increased the risk of MDD onset. There was no multiplicative interaction between NPTs and Rs9540720 (OR = 1.51, 95% CI: 0.30–7.63). Furthermore, there was no additive interaction between them (RERI = 2.40, 95% CI: –0.82–5.62; AP = 0.47, 95% CI: –0.04–0.97; and S = 2.37, 95% CI: 0.54–10.33).Conclusion:PCDH9 (rs9540720) and more NPTs are the risk factors for the incidence of MDD in Chinese first-year university students. |
| first_indexed | 2024-03-08T05:11:38Z |
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| id | doaj.art-e77368325b1d49e99d841fdebf451838 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-03-08T05:11:38Z |
| publishDate | 2024-02-01 |
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| series | Frontiers in Genetics |
| spelling | doaj.art-e77368325b1d49e99d841fdebf4518382024-02-07T09:32:12ZengFrontiers Media S.A.Frontiers in Genetics1664-80212024-02-011410.3389/fgene.2023.12679721267972Influence of PCDH9 (rs9540720) and narcissistic personality traits on the incidence of major depressive disorder in Chinese first-year university students: findings from a 2-year cohort studyRuixue Xu0Ruixue Xu1Zhaorui Liu2Hanyun Li3Linlin Luo4Yi Zheng5Fuqin Mu6Yujia Liu7Weixin Zhang8Ying Zhang9Jianli Wang10Jianli Wang11Yan Liu12School of Public Health, Binzhou Medical University, Yantai, ChinaSchool of Public Health, Jining Medical University, Jining, ChinaNHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University Sixth Hospital, Peking University Institute of Mental Health, Beijing, ChinaCheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Hematology, Tai’an City Central Hospital of Qingdao University, Tai’an, ChinaSchool of Mental Health, Jining Medical University, Jining, ChinaSchool of Mental Health, Jining Medical University, Jining, ChinaMelbourne School of Psychological Sciences, The University of Melbourne, Melbourne, VIC, AustraliaSchool of Clinical Medicine, Jining Medical University, Jining, ChinaSchool of Public Health, University of Sydney, Sydney, NSW, AustraliaSchool of Mental Health, Jining Medical University, Jining, China0Department of Community Health and Epidemiology, Faculty of Medicine, Dalhousie University, Halifax, NS, CanadaSchool of Public Health, Jining Medical University, Jining, ChinaObjective: The objective of this study was to explore the influence of the polymorphism of the protocadherin 9 (PCDH9) gene and the narcissistic personality trait (NPT) on the risk of major depressive disorder (MDD) in Chinese first-year university students.Methods: A 2-year cohort study was conducted among Chinese first-year university students who were enrolled in 2018 from two universities in Shandong Province, China. The snapshot technique was used to detect the genotypes of PCDH9 (rs9540720). The Chinese version of the Composite International Diagnostic Interview was used for the MDD assessment. The NPTs were measured by 11 items based on DSM-IV. Patient Health Questionnaire-9 and the Beck Anxiety Inventory were used to assess depressive and anxiety symptoms, respectively. Logistic regression modeling was carried out to examine the relationship between rs9540720, NPTs, and the incidence of MDD.Results: A total of 5,327 students participated in the baseline and follow-up studies and provided their blood samples. PCDH9 (rs9540720) (ORGG+GA = 2.33, 95% CI: 1.35–4.02) and NPTs (OR5–9 = 2.26, 95% CI: 1.40–3.64) increased the risk of MDD onset. There was no multiplicative interaction between NPTs and Rs9540720 (OR = 1.51, 95% CI: 0.30–7.63). Furthermore, there was no additive interaction between them (RERI = 2.40, 95% CI: –0.82–5.62; AP = 0.47, 95% CI: –0.04–0.97; and S = 2.37, 95% CI: 0.54–10.33).Conclusion:PCDH9 (rs9540720) and more NPTs are the risk factors for the incidence of MDD in Chinese first-year university students.https://www.frontiersin.org/articles/10.3389/fgene.2023.1267972/fullprotocadherin genenarcissistic personality traitsmajor depressive disorderfirst-year university studentscohort study |
| spellingShingle | Ruixue Xu Ruixue Xu Zhaorui Liu Hanyun Li Linlin Luo Yi Zheng Fuqin Mu Yujia Liu Weixin Zhang Ying Zhang Jianli Wang Jianli Wang Yan Liu Influence of PCDH9 (rs9540720) and narcissistic personality traits on the incidence of major depressive disorder in Chinese first-year university students: findings from a 2-year cohort study Frontiers in Genetics protocadherin gene narcissistic personality traits major depressive disorder first-year university students cohort study |
| title | Influence of PCDH9 (rs9540720) and narcissistic personality traits on the incidence of major depressive disorder in Chinese first-year university students: findings from a 2-year cohort study |
| title_full | Influence of PCDH9 (rs9540720) and narcissistic personality traits on the incidence of major depressive disorder in Chinese first-year university students: findings from a 2-year cohort study |
| title_fullStr | Influence of PCDH9 (rs9540720) and narcissistic personality traits on the incidence of major depressive disorder in Chinese first-year university students: findings from a 2-year cohort study |
| title_full_unstemmed | Influence of PCDH9 (rs9540720) and narcissistic personality traits on the incidence of major depressive disorder in Chinese first-year university students: findings from a 2-year cohort study |
| title_short | Influence of PCDH9 (rs9540720) and narcissistic personality traits on the incidence of major depressive disorder in Chinese first-year university students: findings from a 2-year cohort study |
| title_sort | influence of pcdh9 rs9540720 and narcissistic personality traits on the incidence of major depressive disorder in chinese first year university students findings from a 2 year cohort study |
| topic | protocadherin gene narcissistic personality traits major depressive disorder first-year university students cohort study |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2023.1267972/full |
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