Unveiling the Hidden Potential of Simple but Promising Blood Cell Parameters on Acute Myocardial Infarction Prognostication
Background: Non-ST-elevation myocardial infarction (NSTEMI), a disease of mounting interest, continues to pose challenges and cast shadows of doubt on determining the optimal timing for revascularization. The current guidelines on NSTEMI recommend coronary angiography based on the GRACE score, empha...
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MDPI AG
2024-03-01
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| Online Access: | https://www.mdpi.com/2076-3417/14/6/2545 |
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| author | Cosmina Elena Jercălău Cătălina Liliana Andrei Lavinia Nicoleta Brezeanu Roxana Oana Darabont Suzana Guberna Gabriela Postolea Octavian Ceban Crina Julieta Sinescu |
| author_facet | Cosmina Elena Jercălău Cătălina Liliana Andrei Lavinia Nicoleta Brezeanu Roxana Oana Darabont Suzana Guberna Gabriela Postolea Octavian Ceban Crina Julieta Sinescu |
| author_sort | Cosmina Elena Jercălău |
| collection | DOAJ |
| description | Background: Non-ST-elevation myocardial infarction (NSTEMI), a disease of mounting interest, continues to pose challenges and cast shadows of doubt on determining the optimal timing for revascularization. The current guidelines on NSTEMI recommend coronary angiography based on the GRACE score, emphasizing the critical need for early invasive assessment (within 24 h); very-high-risk patients have to undergo this intervention even sooner, within 2 h. We believe that a reality check of these assumptions is needed and that we should endeavor to update these strategies using new predictive markers. Materials and methods: Our study included patients hospitalized for NSTEMI over the course of 16 months. Simple blood parameters, namely MCV (mean corpuscular volume), MPV (mean platelet volume), RDW (red blood cell distribution width), and PDW (platelet distribution width), were analyzed in correlation with the extent of the myocardial infarction area and with complications during hospitalization and at 30-day follow-up. Results: The parameters mentioned above have been identified as statistically relevant indicators of prognosis in patients with NSTEMI. Conclusions: In the present day, living in the world of the blue sky concept allows us to search for new diagnostic algorithms. Therefore, the combination of these parameters can constitute the DNA strands of a new and up-to-date score stratification. |
| first_indexed | 2024-04-24T18:35:02Z |
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| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-04-24T18:35:02Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
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| series | Applied Sciences |
| spelling | doaj.art-e773fca94ac74bbf8619089b86c8c6b62024-03-27T13:20:03ZengMDPI AGApplied Sciences2076-34172024-03-01146254510.3390/app14062545Unveiling the Hidden Potential of Simple but Promising Blood Cell Parameters on Acute Myocardial Infarction PrognosticationCosmina Elena Jercălău0Cătălina Liliana Andrei1Lavinia Nicoleta Brezeanu2Roxana Oana Darabont3Suzana Guberna4Gabriela Postolea5Octavian Ceban6Crina Julieta Sinescu7Department of Cardiology, “Bagdasar Arseni” Emergency Hospital, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Cardiology, “Bagdasar Arseni” Emergency Hospital, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Anaesthesia and Intensive Care I, Fundeni Clinical Institute, 022322 Bucharest, RomaniaDepartment of Cardiology, “Bagdasar Arseni” Emergency Hospital, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Cardiology, Emergency Hospital “Bagdasar-Arseni”, 050474 Bucharest, RomaniaDepartment of Internal Medicine, “Coltea” Clinical Hospital, 030167 Bucharest, RomaniaEconomic Cybernetics and Informatics Department, The Bucharest University of Economic Studies, 010374 Bucharest, RomaniaDepartment of Cardiology, “Bagdasar Arseni” Emergency Hospital, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaBackground: Non-ST-elevation myocardial infarction (NSTEMI), a disease of mounting interest, continues to pose challenges and cast shadows of doubt on determining the optimal timing for revascularization. The current guidelines on NSTEMI recommend coronary angiography based on the GRACE score, emphasizing the critical need for early invasive assessment (within 24 h); very-high-risk patients have to undergo this intervention even sooner, within 2 h. We believe that a reality check of these assumptions is needed and that we should endeavor to update these strategies using new predictive markers. Materials and methods: Our study included patients hospitalized for NSTEMI over the course of 16 months. Simple blood parameters, namely MCV (mean corpuscular volume), MPV (mean platelet volume), RDW (red blood cell distribution width), and PDW (platelet distribution width), were analyzed in correlation with the extent of the myocardial infarction area and with complications during hospitalization and at 30-day follow-up. Results: The parameters mentioned above have been identified as statistically relevant indicators of prognosis in patients with NSTEMI. Conclusions: In the present day, living in the world of the blue sky concept allows us to search for new diagnostic algorithms. Therefore, the combination of these parameters can constitute the DNA strands of a new and up-to-date score stratification.https://www.mdpi.com/2076-3417/14/6/2545biomarkerscoronary angiographynon-ST-elevation myocardial infarctionprognosisscore risk |
| spellingShingle | Cosmina Elena Jercălău Cătălina Liliana Andrei Lavinia Nicoleta Brezeanu Roxana Oana Darabont Suzana Guberna Gabriela Postolea Octavian Ceban Crina Julieta Sinescu Unveiling the Hidden Potential of Simple but Promising Blood Cell Parameters on Acute Myocardial Infarction Prognostication Applied Sciences biomarkers coronary angiography non-ST-elevation myocardial infarction prognosis score risk |
| title | Unveiling the Hidden Potential of Simple but Promising Blood Cell Parameters on Acute Myocardial Infarction Prognostication |
| title_full | Unveiling the Hidden Potential of Simple but Promising Blood Cell Parameters on Acute Myocardial Infarction Prognostication |
| title_fullStr | Unveiling the Hidden Potential of Simple but Promising Blood Cell Parameters on Acute Myocardial Infarction Prognostication |
| title_full_unstemmed | Unveiling the Hidden Potential of Simple but Promising Blood Cell Parameters on Acute Myocardial Infarction Prognostication |
| title_short | Unveiling the Hidden Potential of Simple but Promising Blood Cell Parameters on Acute Myocardial Infarction Prognostication |
| title_sort | unveiling the hidden potential of simple but promising blood cell parameters on acute myocardial infarction prognostication |
| topic | biomarkers coronary angiography non-ST-elevation myocardial infarction prognosis score risk |
| url | https://www.mdpi.com/2076-3417/14/6/2545 |
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