Novel TLR7 hemizygous variant in post-COVID-19 neurological deterioration: a case report with literature review

Novel TLR7 hemizygous variant in post-COVID-19 neurological deterioration: a case report with literature review

The neurological complications of coronavirus disease 2019 (COVID-19) can range from simple tremors and dystonia to features of encephalopathy. Toll-like receptor 7 (TLR7) belongs to a family of innate immune receptors responsible for viral RNA detection (such as SARS-CoV-2) and immune response init...

Full description

Bibliographic Details
Main Authors:	Ahmed Noor Eddin, Mohammed Al-Rimawi, Feham Peer-Zada, Khalid Hundallah, Amal Alhashem
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-11-01
Series:	Frontiers in Neurology
Subjects:	COVID-19 SARS-CoV-2 TLR7 hemizygous neurological deterioration immunodeficiency
Online Access:	https://www.frontiersin.org/articles/10.3389/fneur.2023.1268035/full

Similar Items

Congenital Myasthenic Syndrome Caused by a Novel Hemizygous CHAT Mutation
by: Yixia Zhang, et al.
Published: (2020-04-01)

A hemizygous p.R204Q mutation in the ALAS2 gene underlies X-linked sideroblastic anemia in an adult Chinese Han man
by: Jinbo Huang, et al.
Published: (2021-04-01)

An unusual case of uninterrupted inferior vena cava with accessory hemizygous channel: An incidental finding in a child
by: Gaurav Agrawal, et al.
Published: (2020-01-01)

Deleterious variants in TAF7L cause human oligoasthenoteratozoospermia and its impairing histone to protamine exchange inducing reduced in vitro fertilization
by: Haowei Bai, et al.
Published: (2023-01-01)

Mild Luminal Stenosis of Parent Artery and Neurologic Deterioration After Acute Lacunar Stroke
by: Dixon Yang, et al.
Published: (2022-01-01)

Prediction of Neurological Deterioration After Intracerebral Hemorrhage: The SIGNALS Score
by: Quanwei He, et al.
Published: (2022-08-01)

Prospective study on relationship between legumain and early neurological deterioration in patients with acute large artery atherosclerotic stroke
by: RONG Tianyi, HUA Yun, CHEN Deyan, HE Min
Published: (2021-04-01)

Malnutrition and the Risk of Early Neurological Deterioration in Elderly Patients with Acute Ischemic Stroke
by: Bao Y, et al.
Published: (2022-08-01)

High Uric Acid Level Predicts Early Neurological Deterioration in Intracerebral Hemorrhage
by: Gong X, et al.
Published: (2021-08-01)

Neurological Deterioration in Intracerebral Hemorrhage: Can We Predict It, and What Would We Do If We Could?
by: Qi Li, et al.
Published: (2022-08-01)

The Length of an Infarcted Lesion Along the Perforating Artery Predicts Neurological Deterioration in Single Subcortical Infarction Without Any Relevant Artery Stenosis
by: Seong Hwa Jang, et al.
Published: (2020-09-01)

Increased serum alkaline phosphatase and early neurological deterioration in patients with atherothrombotic brain infarction attributable to intracranial atherosclerosis
by: Toshiyuki Uehara, et al.
Published: (2020-09-01)

Predictive values of systemic inflammatory responses index in early neurological deterioration in patients with acute ischemic stroke
by: Jia Wang, et al.
Published: (2022-05-01)

Neurological deterioration and computed tomography perfusion changes with increased time to peak in lacunar stroke
by: AmreenFarooqui, et al.
Published: (2022-01-01)

Predictive factors of neurologic deterioration in patients with spontaneous cerebellar hemorrhage: a retrospective analysis
by: Yu-Ni Ho, et al.
Published: (2019-05-01)

The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling
by: D Garrett Brown, et al.
Published: (2019-07-01)

Variants in clopidogrel-relevant genes and early neurological deterioration in ischemic stroke patients receiving clopidogrel
by: Xingyang Yi, et al.
Published: (2020-04-01)

Usability of serum annexin A7 as a biochemical marker of poor outcome and early neurological deterioration after acute primary intracerebral hemorrhage: A prospective cohort study
by: Chuan-Liu Wang, et al.
Published: (2022-08-01)

Association of triglyceride-glucose index with early neurological deterioration events in patients with acute ischemic stroke
by: Jia Wang, et al.
Published: (2023-05-01)

A study with focus on course and outcome of delayed neurological deterioration in mild head injury patients
by: Sachin Dhakad, et al.
Published: (2023-10-01)

Identifying the Risk Factors of Early Neurological Deterioration After Thrombolysis in Patients with Acute Ischemic Stroke
by: Yasemin Dinç, et al.
Published: (2022-09-01)

Genetic Screening for TLR7 Variants in Young and Previously Healthy Men With Severe COVID-19
by: Xavier Solanich, et al.
Published: (2021-07-01)

Increased pulsatility index of the basilar artery is a risk factor for neurological deterioration after stroke: a case control study
by: Il-Han Yoo, et al.
Published: (2022-08-01)

Association of TLR7 and TLR9 genes polymorphisms in Egyptian patients with systemic lupus erythematosus
by: Marwa M. Azab, et al.
Published: (2022-11-01)

Post-thrombolysis early neurological deterioration occurs with or without hemorrhagic transformation in acute cerebral infarction: risk factors, prediction model and prognosis
by: Mengzhi Jin, et al.
Published: (2023-05-01)

Predictors of early neurological deterioration following intravenous thrombolysis: Difference between risk factors for ischemic and hemorrhagic worsening
by: Srikumar B Nair, et al.
Published: (2022-01-01)

A Prediction Model for Neurological Deterioration in Patients with Acute Spontaneous Intracerebral Hemorrhage
by: Daiquan Gao, et al.
Published: (2022-05-01)

TLR7/8 in the Pathogenesis of Parkinson’s Disease
by: Michela Campolo, et al.
Published: (2020-12-01)

A novel mutation in CFAP47 causes male infertility due to multiple morphological abnormalities of the sperm flagella
by: Mohan Liu, et al.
Published: (2023-06-01)

Ultraearly Intraventricular Hemorrhage Growth Predicts Early Neurologic Deterioration and Poor Functional Outcome After Acute Intracerebral Hemorrhage
by: Xin‐Ni Lv, et al.
Published: (2023-11-01)

The Relevance of TLR8 in Viral Infections
by: Iván Martínez-Espinoza, et al.
Published: (2022-01-01)

Predictors of Early Neurological Deterioration in Stroke Due to Vertebrobasilar Occlusion
by: Seungyon Koh, et al.
Published: (2021-09-01)

Admission Glucose Levels May Increase the Risk for Early Neurological Deterioration in Females With Acute Ischemic Stroke
by: Zhi-Xin Huang, et al.
Published: (2020-11-01)

Time-Dependent Changes in Hematoma Expansion Rate after Supratentorial Intracerebral Hemorrhage and Its Relationship with Neurological Deterioration and Functional Outcome
by: Gaby Abou Karam, et al.
Published: (2024-01-01)

A Systematic Review of Body Fluids Biomarkers Associated With Early Neurological Deterioration Following Acute Ischemic Stroke
by: Xiaotan Ji, et al.
Published: (2022-05-01)

Impact of High-Intensity Statin on Early Neurologic Deterioration in Patients with Single Small Subcortical Infarction
by: Seong Hwa Jang, et al.
Published: (2023-05-01)

A nomogram predicts early neurological deterioration after mechanical thrombectomy in patients with ischemic stroke
by: Kongyuan Wu, et al.
Published: (2023-09-01)

Serum uric acid to serum creatinine ratio predicts neurological deterioration in branch atheromatous disease
by: Yinglin Liu, et al.
Published: (2023-01-01)

Serum neurofilament light chain levels are associated with early neurological deterioration in minor ischemic stroke
by: Jie Li, et al.
Published: (2023-03-01)

Unplanned Second-Stage Decompression for Neurological Deterioration Caused by Central Canal Stenosis after Indirect Lumbar Decompression Surgery
by: Hiroaki Nakashima, et al.
Published: (2019-08-01)