Signalisation apototique induite par les LDL oxydées Implication dans l’athérosclérose
The balance between vascular cell proliferation vs apoptosis plays a key role in vessel wall remodeling. Intimal migration and proliferation of smooth muscle cells (SMC), and secretion of extracellular matrix are involved in fibrous cap formation and plaque stability, whereas apoptosis of vascular c...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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EDP Sciences
2006-01-01
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| Series: | Oléagineux, Corps gras, Lipides |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1051/ocl.2006.4444 |
| _version_ | 1819276772629282816 |
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| author | Negre-Salvayre Anne Vindis Cécile Salvayre Robert |
| author_facet | Negre-Salvayre Anne Vindis Cécile Salvayre Robert |
| author_sort | Negre-Salvayre Anne |
| collection | DOAJ |
| description | The balance between vascular cell proliferation vs apoptosis plays a key role in vessel wall remodeling. Intimal migration and proliferation of smooth muscle cells (SMC), and secretion of extracellular matrix are involved in fibrous cap formation and plaque stability, whereas apoptosis of vascular cells may contribute to the erosion and instability of the plaque leading to its rupture and subsequent thrombus formation. LDL become atherogenic after undergoing oxidation within the vascular wall. Oxidized LDL (oxLDL) and oxidized lipids exhibit complex biological properties involved in endothelial dysfunction, SMC migration and proliferation, inflammation, and apoptosis. Oxidized LDL-induced apoptosis involves the extrinsic propapoptotic pathway (linked to Fas/Fas ligand) in lymphocytes, and the intrinsic mitochondrial apoptotic pathway, involving bcl-2 family members, cytochrome C release, and the terminal executive caspase-3 pathway, as well as the mitochondrial apoptotic factor AIF, in vascular cells. The apoptotic signaling of oxLDL is mediated in part by an intense and sustained rise of cytosolic calcium. The mechanisms regulating the balance between proliferation and apoptosis triggered by oxLDL and their role in vivo in atherosclerotic plaque progression remains to be clarified. |
| first_indexed | 2024-12-23T23:45:32Z |
| format | Article |
| id | doaj.art-e7767e98dd85411c9d264de498bd6f9f |
| institution | Directory Open Access Journal |
| issn | 1258-8210 1950-697X |
| language | English |
| last_indexed | 2024-12-23T23:45:32Z |
| publishDate | 2006-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | Oléagineux, Corps gras, Lipides |
| spelling | doaj.art-e7767e98dd85411c9d264de498bd6f9f2022-12-21T17:25:31ZengEDP SciencesOléagineux, Corps gras, Lipides1258-82101950-697X2006-01-01131394510.1051/ocl.2006.4444ocl2006131p39Signalisation apototique induite par les LDL oxydées Implication dans l’athéroscléroseNegre-Salvayre AnneVindis CécileSalvayre RobertThe balance between vascular cell proliferation vs apoptosis plays a key role in vessel wall remodeling. Intimal migration and proliferation of smooth muscle cells (SMC), and secretion of extracellular matrix are involved in fibrous cap formation and plaque stability, whereas apoptosis of vascular cells may contribute to the erosion and instability of the plaque leading to its rupture and subsequent thrombus formation. LDL become atherogenic after undergoing oxidation within the vascular wall. Oxidized LDL (oxLDL) and oxidized lipids exhibit complex biological properties involved in endothelial dysfunction, SMC migration and proliferation, inflammation, and apoptosis. Oxidized LDL-induced apoptosis involves the extrinsic propapoptotic pathway (linked to Fas/Fas ligand) in lymphocytes, and the intrinsic mitochondrial apoptotic pathway, involving bcl-2 family members, cytochrome C release, and the terminal executive caspase-3 pathway, as well as the mitochondrial apoptotic factor AIF, in vascular cells. The apoptotic signaling of oxLDL is mediated in part by an intense and sustained rise of cytosolic calcium. The mechanisms regulating the balance between proliferation and apoptosis triggered by oxLDL and their role in vivo in atherosclerotic plaque progression remains to be clarified.http://dx.doi.org/10.1051/ocl.2006.4444oxidized LDLapoptosisnecrosisatherosclerosiscell signalingcalcium |
| spellingShingle | Negre-Salvayre Anne Vindis Cécile Salvayre Robert Signalisation apototique induite par les LDL oxydées Implication dans l’athérosclérose Oléagineux, Corps gras, Lipides oxidized LDL apoptosis necrosis atherosclerosis cell signaling calcium |
| title | Signalisation apototique induite par les LDL oxydées Implication dans l’athérosclérose |
| title_full | Signalisation apototique induite par les LDL oxydées Implication dans l’athérosclérose |
| title_fullStr | Signalisation apototique induite par les LDL oxydées Implication dans l’athérosclérose |
| title_full_unstemmed | Signalisation apototique induite par les LDL oxydées Implication dans l’athérosclérose |
| title_short | Signalisation apototique induite par les LDL oxydées Implication dans l’athérosclérose |
| title_sort | signalisation apototique induite par les ldl oxydees implication dans l atherosclerose |
| topic | oxidized LDL apoptosis necrosis atherosclerosis cell signaling calcium |
| url | http://dx.doi.org/10.1051/ocl.2006.4444 |
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