Ethylmethylhydroxypyridine succinate, acetylcysteine and choline alphoscerate improve mitochondrial function under condition of cerebral ischemia in rat
The study was devoted to see the effect of ethylmethylhydroxypyridine succinate, acetylcysteine and choline alphoscerate on the mitochondrial function under condition of experimental cerebral ischemia in rat. An integrated approach was used with the assessment of changes in the respirometric and ant...
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| Format: | Article |
| Language: | English |
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Bangladesh Pharmacological Society
2019-08-01
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| Series: | Bangladesh Journal of Pharmacology |
| Subjects: | |
| Online Access: | https://www.banglajol.info/index.php/BJP/article/view/40977 |
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| author | Pozdnyakov I. Dmitry Nygaryan A. Syranusch Voronkov V. Andrey Anastasya Sosnovskaya Cherechkova I. Elisaveta |
| author_facet | Pozdnyakov I. Dmitry Nygaryan A. Syranusch Voronkov V. Andrey Anastasya Sosnovskaya Cherechkova I. Elisaveta |
| author_sort | Pozdnyakov I. Dmitry |
| collection | DOAJ |
| description | The study was devoted to see the effect of ethylmethylhydroxypyridine succinate, acetylcysteine and choline alphoscerate on the mitochondrial function under condition of experimental cerebral ischemia in rat. An integrated approach was used with the assessment of changes in the respirometric and antiapoptotic functions of mitochondria. It was found that the application of the objects under study contributed to a decrease in the intensity of glycolysis and the restoration of aerobic glucose metabolism with an increase in ATP synthesis, as well as a decrease in the dissociation of reactions in mitochondrial complexes I, II, IV and V. In addition, the introduction of the studied drugs reduced the intensity of caspase-dependent and caspase-independent apoptosis reactions, which, together with the restoration of mitochondrial respiratory function, contributed to the decrease in the size of the necrosis zone of the brain.
Video Clip of Methodology:
Rat middle cerebral artery occlusion: 8 min 7 sec Full Screen Alternate |
| first_indexed | 2024-12-10T17:54:11Z |
| format | Article |
| id | doaj.art-e776c73ec595458c9144887792a1ae43 |
| institution | Directory Open Access Journal |
| issn | 1991-0088 |
| language | English |
| last_indexed | 2024-12-10T17:54:11Z |
| publishDate | 2019-08-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-e776c73ec595458c9144887792a1ae432022-12-22T01:39:00ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882019-08-0114310.3329/bjp.v14i3.40977Ethylmethylhydroxypyridine succinate, acetylcysteine and choline alphoscerate improve mitochondrial function under condition of cerebral ischemia in ratPozdnyakov I. Dmitry0Nygaryan A. Syranusch1Voronkov V. Andrey2Anastasya SosnovskayaCherechkova I. Elisaveta3Department of Pharmacology with Course of Clinical Pharmacology, Pyatigorsk Medical and Pharmaceutical Institute, A Branch Volgograd State Medical University, Pyatigorsk, Russia (357532, Pyatigorsk, av. Kalinina 11).Department of Pharmacology with Course of Clinical Pharmacology, Pyatigorsk Medical and Pharmaceutical Institute, A Branch Volgograd State Medical University, Pyatigorsk, Russia (357532, Pyatigorsk, av. Kalinina 11).Department of Pharmacology with Course of Clinical Pharmacology, Pyatigorsk Medical and Pharmaceutical Institute, A Branch Volgograd State Medical University, Pyatigorsk, Russia (357532, Pyatigorsk, av. Kalinina 11).Department of Pharmacology with Course of Clinical Pharmacology, Pyatigorsk Medical and Pharmaceutical Institute, A Branch Volgograd State Medical University, Pyatigorsk, Russia (357532, Pyatigorsk, av. Kalinina 11).The study was devoted to see the effect of ethylmethylhydroxypyridine succinate, acetylcysteine and choline alphoscerate on the mitochondrial function under condition of experimental cerebral ischemia in rat. An integrated approach was used with the assessment of changes in the respirometric and antiapoptotic functions of mitochondria. It was found that the application of the objects under study contributed to a decrease in the intensity of glycolysis and the restoration of aerobic glucose metabolism with an increase in ATP synthesis, as well as a decrease in the dissociation of reactions in mitochondrial complexes I, II, IV and V. In addition, the introduction of the studied drugs reduced the intensity of caspase-dependent and caspase-independent apoptosis reactions, which, together with the restoration of mitochondrial respiratory function, contributed to the decrease in the size of the necrosis zone of the brain. Video Clip of Methodology: Rat middle cerebral artery occlusion: 8 min 7 sec Full Screen Alternatehttps://www.banglajol.info/index.php/BJP/article/view/40977AcetylcysteineCerebral ischemiaCholine alphoscerateEthylmethylhydroxypyridineMitochondrial functionRat |
| spellingShingle | Pozdnyakov I. Dmitry Nygaryan A. Syranusch Voronkov V. Andrey Anastasya Sosnovskaya Cherechkova I. Elisaveta Ethylmethylhydroxypyridine succinate, acetylcysteine and choline alphoscerate improve mitochondrial function under condition of cerebral ischemia in rat Bangladesh Journal of Pharmacology Acetylcysteine Cerebral ischemia Choline alphoscerate Ethylmethylhydroxypyridine Mitochondrial function Rat |
| title | Ethylmethylhydroxypyridine succinate, acetylcysteine and choline alphoscerate improve mitochondrial function under condition of cerebral ischemia in rat |
| title_full | Ethylmethylhydroxypyridine succinate, acetylcysteine and choline alphoscerate improve mitochondrial function under condition of cerebral ischemia in rat |
| title_fullStr | Ethylmethylhydroxypyridine succinate, acetylcysteine and choline alphoscerate improve mitochondrial function under condition of cerebral ischemia in rat |
| title_full_unstemmed | Ethylmethylhydroxypyridine succinate, acetylcysteine and choline alphoscerate improve mitochondrial function under condition of cerebral ischemia in rat |
| title_short | Ethylmethylhydroxypyridine succinate, acetylcysteine and choline alphoscerate improve mitochondrial function under condition of cerebral ischemia in rat |
| title_sort | ethylmethylhydroxypyridine succinate acetylcysteine and choline alphoscerate improve mitochondrial function under condition of cerebral ischemia in rat |
| topic | Acetylcysteine Cerebral ischemia Choline alphoscerate Ethylmethylhydroxypyridine Mitochondrial function Rat |
| url | https://www.banglajol.info/index.php/BJP/article/view/40977 |
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