Amount of tobacco consumption is associated with superficial bladder cancer progression
Objective: To evaluate the association between smoking habits and outcome of patients with superficial bladder cancer. Methods: A retrospective study was performed evaluating 99 patients (67.0 ± 13.2 years, ranging from 31.4-93.4 years, 72.7% males and 27.3% females) treated at our institution with...
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| Format: | Article |
| Language: | English |
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Instituto Israelita de Ensino e Pesquisa Albert Einstein
2010-12-01
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| Series: | Einstein (São Paulo) |
| Subjects: | |
| Online Access: | http://apps.einstein.br/revista/arquivos/PDF/1751-Einsteinv8n4_pg473-476_eng.pdf |
| _version_ | 1828446634411819008 |
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| author | Fernando Korkes César Augusto Braz Juliano Maria Alice Peluso Bunduky Ana Carolina Duarte Martins Costa Marilia Germanos de Castro |
| author_facet | Fernando Korkes César Augusto Braz Juliano Maria Alice Peluso Bunduky Ana Carolina Duarte Martins Costa Marilia Germanos de Castro |
| author_sort | Fernando Korkes |
| collection | DOAJ |
| description | Objective: To evaluate the association between smoking habits and outcome of patients with superficial bladder cancer. Methods: A retrospective study was performed evaluating 99 patients (67.0 ± 13.2 years, ranging from 31.4-93.4 years, 72.7% males and 27.3% females) treated at our institution with non muscle-invasive bladder cancer, between 1994 and 2000, with a mean follow-up of 49.3 months (range 4.0-177.9 months). Patients were divided according to smoking status, and the main measured outcome was progression to invasive disease. Additional cohort analysis was performed dividing patients according to previous tobacco exposure: smokers and non-smokers. Smokers were stratified into former smokers, early-quitters, late quitters and continued smokers. Results: Smoking habit was significantly more common in males (p = 0.03). Cancer also occurred at an earlier age among smokers (70.8 versus 64.8 years, p = 0.030). Tobacco consumption was present in 62.7% of the patients with bladder cancer. There was a significant higher progression rate to muscle-invasive disease in patients that had more than 60 pack-years of exposure (52.9 versus 26.2%, p = 0.037). These patients had a mean progression time of 59.3 months, whereas patients who had smoked less than 60 pack-years progressed after a mean time of 131.8 months. Conclusions: A direct association between the amount of tobacco consumed and disease progression is observed in patients with bladder cancer, as suggested by the present study. Tobacco consumption has a direct association with progression of superficial bladder cancer to invasive disease and also shortens the period of time for muscle invasion. Larger and prospective studies are still necessary to bring further definitive conclusions about reproducibility of our data and to better understand how smoking cessation affects progression of superficial bladder cancer. |
| first_indexed | 2024-12-10T22:15:05Z |
| format | Article |
| id | doaj.art-e7771b3ae804491b96461649d10987b0 |
| institution | Directory Open Access Journal |
| issn | 1679-4508 |
| language | English |
| last_indexed | 2024-12-10T22:15:05Z |
| publishDate | 2010-12-01 |
| publisher | Instituto Israelita de Ensino e Pesquisa Albert Einstein |
| record_format | Article |
| series | Einstein (São Paulo) |
| spelling | doaj.art-e7771b3ae804491b96461649d10987b02022-12-22T01:31:30ZengInstituto Israelita de Ensino e Pesquisa Albert EinsteinEinstein (São Paulo)1679-45082010-12-0184473476Amount of tobacco consumption is associated with superficial bladder cancer progressionFernando KorkesCésar Augusto Braz JulianoMaria Alice Peluso BundukyAna Carolina Duarte Martins CostaMarilia Germanos de CastroObjective: To evaluate the association between smoking habits and outcome of patients with superficial bladder cancer. Methods: A retrospective study was performed evaluating 99 patients (67.0 ± 13.2 years, ranging from 31.4-93.4 years, 72.7% males and 27.3% females) treated at our institution with non muscle-invasive bladder cancer, between 1994 and 2000, with a mean follow-up of 49.3 months (range 4.0-177.9 months). Patients were divided according to smoking status, and the main measured outcome was progression to invasive disease. Additional cohort analysis was performed dividing patients according to previous tobacco exposure: smokers and non-smokers. Smokers were stratified into former smokers, early-quitters, late quitters and continued smokers. Results: Smoking habit was significantly more common in males (p = 0.03). Cancer also occurred at an earlier age among smokers (70.8 versus 64.8 years, p = 0.030). Tobacco consumption was present in 62.7% of the patients with bladder cancer. There was a significant higher progression rate to muscle-invasive disease in patients that had more than 60 pack-years of exposure (52.9 versus 26.2%, p = 0.037). These patients had a mean progression time of 59.3 months, whereas patients who had smoked less than 60 pack-years progressed after a mean time of 131.8 months. Conclusions: A direct association between the amount of tobacco consumed and disease progression is observed in patients with bladder cancer, as suggested by the present study. Tobacco consumption has a direct association with progression of superficial bladder cancer to invasive disease and also shortens the period of time for muscle invasion. Larger and prospective studies are still necessary to bring further definitive conclusions about reproducibility of our data and to better understand how smoking cessation affects progression of superficial bladder cancer.http://apps.einstein.br/revista/arquivos/PDF/1751-Einsteinv8n4_pg473-476_eng.pdfUrinary bladderCarcinomatransitional cellSurvival analysisSmokingSmoking cessationNeoplasm recurrencelocal |
| spellingShingle | Fernando Korkes César Augusto Braz Juliano Maria Alice Peluso Bunduky Ana Carolina Duarte Martins Costa Marilia Germanos de Castro Amount of tobacco consumption is associated with superficial bladder cancer progression Einstein (São Paulo) Urinary bladder Carcinoma transitional cell Survival analysis Smoking Smoking cessation Neoplasm recurrence local |
| title | Amount of tobacco consumption is associated with superficial bladder cancer progression |
| title_full | Amount of tobacco consumption is associated with superficial bladder cancer progression |
| title_fullStr | Amount of tobacco consumption is associated with superficial bladder cancer progression |
| title_full_unstemmed | Amount of tobacco consumption is associated with superficial bladder cancer progression |
| title_short | Amount of tobacco consumption is associated with superficial bladder cancer progression |
| title_sort | amount of tobacco consumption is associated with superficial bladder cancer progression |
| topic | Urinary bladder Carcinoma transitional cell Survival analysis Smoking Smoking cessation Neoplasm recurrence local |
| url | http://apps.einstein.br/revista/arquivos/PDF/1751-Einsteinv8n4_pg473-476_eng.pdf |
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