Facile fabrication of Nishamalaki churna mediated silver nanoparticles with antibacterial application
Antimicrobial resistance (AMR) is one of the most serious threats to today's healthcare system. The prime factor behind increasing AMR is the formation of complex bacterial biofilms which acts as the protective shield between the bacterial cell and the antimicrobial drugs. Among various nanofor...
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| Format: | Article |
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Elsevier
2023-08-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023059960 |
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| author | Bhavna Ghosh Anindya Bose Ankita Parmanik Sanjay Ch Milan Paul Swati Biswas Goutam Rath Debapriya Bhattacharya |
| author_facet | Bhavna Ghosh Anindya Bose Ankita Parmanik Sanjay Ch Milan Paul Swati Biswas Goutam Rath Debapriya Bhattacharya |
| author_sort | Bhavna Ghosh |
| collection | DOAJ |
| description | Antimicrobial resistance (AMR) is one of the most serious threats to today's healthcare system. The prime factor behind increasing AMR is the formation of complex bacterial biofilms which acts as the protective shield between the bacterial cell and the antimicrobial drugs. Among various nanoformulations, green synthesized metallic silver nanoparticles are currently gaining research focus in safely breaking bacterial biofilms due to the inherent antimicrobial property of silver. In the current work, the aqueous extract of the ayurvedic formulation Nishamalaki churna is used to exhibit one pot green synthesis of silver nanoparticles. The physicochemical characteristics of Nishamalaki churna extract mediated AgNPs were evaluated using various analytical techniques, like UV–Visible spectrophotometer, FT-IR spectroscopy, SEM, XRD, DLS-Zeta potential analyzer etc. The synthesized spherical AgNPs were well formed within the size range of 30 nm to 80 nm. Furthermore, the synthesized AgNPs showed potent antibacterial effects against two primary AMR-causing bacterial species like Staphylococcus aureus and Pseudomonas aeruginosa with the successful destruction of their biofilm formation. Additionally, these AgNPs have shown profound antioxidant and anti-inflammatory activities as desirable add-on effects required by a prospective antibacterial agent. |
| first_indexed | 2024-03-12T12:22:08Z |
| format | Article |
| id | doaj.art-e7779ff616d442a89677b925cb66ae6e |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-12T12:22:08Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-e7779ff616d442a89677b925cb66ae6e2023-08-30T05:52:37ZengElsevierHeliyon2405-84402023-08-0198e18788Facile fabrication of Nishamalaki churna mediated silver nanoparticles with antibacterial applicationBhavna Ghosh0Anindya Bose1Ankita Parmanik2Sanjay Ch3Milan Paul4Swati Biswas5Goutam Rath6Debapriya Bhattacharya7School of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to Be University), Bhubaneswar, Odisha, 751003, India; Sri Jayadev College of Pharmaceutical Sciences, Naharkanta, Via: Balianta, Bhubaneswar, Odisha, 752101, IndiaSchool of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to Be University), Bhubaneswar, Odisha, 751003, India; Corresponding author.School of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to Be University), Bhubaneswar, Odisha, 751003, IndiaDepartment of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus. Jawahar Nagar, Kapra Mandal. Medchal District, Telangana, 500 078, IndiaDepartment of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus. Jawahar Nagar, Kapra Mandal. Medchal District, Telangana, 500 078, IndiaDepartment of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus. Jawahar Nagar, Kapra Mandal. Medchal District, Telangana, 500 078, IndiaSchool of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to Be University), Bhubaneswar, Odisha, 751003, IndiaCenter for Biotechnology, Siksha O Anusandhan (Deemed to Be University), Bhubaneswar, Odisha, 751003, IndiaAntimicrobial resistance (AMR) is one of the most serious threats to today's healthcare system. The prime factor behind increasing AMR is the formation of complex bacterial biofilms which acts as the protective shield between the bacterial cell and the antimicrobial drugs. Among various nanoformulations, green synthesized metallic silver nanoparticles are currently gaining research focus in safely breaking bacterial biofilms due to the inherent antimicrobial property of silver. In the current work, the aqueous extract of the ayurvedic formulation Nishamalaki churna is used to exhibit one pot green synthesis of silver nanoparticles. The physicochemical characteristics of Nishamalaki churna extract mediated AgNPs were evaluated using various analytical techniques, like UV–Visible spectrophotometer, FT-IR spectroscopy, SEM, XRD, DLS-Zeta potential analyzer etc. The synthesized spherical AgNPs were well formed within the size range of 30 nm to 80 nm. Furthermore, the synthesized AgNPs showed potent antibacterial effects against two primary AMR-causing bacterial species like Staphylococcus aureus and Pseudomonas aeruginosa with the successful destruction of their biofilm formation. Additionally, these AgNPs have shown profound antioxidant and anti-inflammatory activities as desirable add-on effects required by a prospective antibacterial agent.http://www.sciencedirect.com/science/article/pii/S2405844023059960Antimicrobial resistanceBiofilmGreen synthesisAyurvedic formulationAmlakiTurmeric |
| spellingShingle | Bhavna Ghosh Anindya Bose Ankita Parmanik Sanjay Ch Milan Paul Swati Biswas Goutam Rath Debapriya Bhattacharya Facile fabrication of Nishamalaki churna mediated silver nanoparticles with antibacterial application Heliyon Antimicrobial resistance Biofilm Green synthesis Ayurvedic formulation Amlaki Turmeric |
| title | Facile fabrication of Nishamalaki churna mediated silver nanoparticles with antibacterial application |
| title_full | Facile fabrication of Nishamalaki churna mediated silver nanoparticles with antibacterial application |
| title_fullStr | Facile fabrication of Nishamalaki churna mediated silver nanoparticles with antibacterial application |
| title_full_unstemmed | Facile fabrication of Nishamalaki churna mediated silver nanoparticles with antibacterial application |
| title_short | Facile fabrication of Nishamalaki churna mediated silver nanoparticles with antibacterial application |
| title_sort | facile fabrication of nishamalaki churna mediated silver nanoparticles with antibacterial application |
| topic | Antimicrobial resistance Biofilm Green synthesis Ayurvedic formulation Amlaki Turmeric |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023059960 |
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