Köbner and Pastia Signs in Acute Hemorrhagic Edema of Young Children: Systematic Literature Review
Acute hemorrhagic edema of young children, a benign skin-limited vasculitis, predominantly affects children 2 years of age or younger. The prevalence and clinical features of the Köbner and Pastia signs have never been systematically investigated in this vasculitis. To address this issue, we analyze...
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MDPI AG
2022-02-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/9/2/265 |
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| author | Gabriel Bronz Danilo Consolascio Mario G. Bianchetti Pietro O. Rinoldi Céline Betti Sebastiano A. G. Lava Gregorio P. Milani |
| author_facet | Gabriel Bronz Danilo Consolascio Mario G. Bianchetti Pietro O. Rinoldi Céline Betti Sebastiano A. G. Lava Gregorio P. Milani |
| author_sort | Gabriel Bronz |
| collection | DOAJ |
| description | Acute hemorrhagic edema of young children, a benign skin-limited vasculitis, predominantly affects children 2 years of age or younger. The prevalence and clinical features of the Köbner and Pastia signs have never been systematically investigated in this vasculitis. To address this issue, we analyzed the data contained in the Acute Hemorrhagic Edema Bibliographic Database, which incorporates all reports on hemorrhagic edema published after 1969. A total of 339 cases (236 males and 103 females; 11 (8–18) months of age; median and interquartile range) were documented with at least 1 photograph and therefore included in this analysis. The Köbner sign occurred in 24 cases (14 males and 10 females; 11 (7–17) months of age), the Pastia sign in 51 cases (39 males and 12 females; 11 (8–15) months of age), and both Köbner and Pastia signs in 8 cases (7 males and 1 female; 11 (7–17) months of age). The lower legs, thighs, waistline, and groin were the regions that were most commonly affected with the Köbner sign, while the ankle, feet, cubital fossa, and elbow were most affected with the Pastia sign. The Köbner and Pastia signs are clinically relevant; they occur in about every fourth child affected with hemorrhagic edema and do not influence the disease progression. |
| first_indexed | 2024-03-09T22:17:43Z |
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| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-09T22:17:43Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-e777a35261de4a61abfe7926a5bb19d82023-11-23T19:20:12ZengMDPI AGChildren2227-90672022-02-019226510.3390/children9020265Köbner and Pastia Signs in Acute Hemorrhagic Edema of Young Children: Systematic Literature ReviewGabriel Bronz0Danilo Consolascio1Mario G. Bianchetti2Pietro O. Rinoldi3Céline Betti4Sebastiano A. G. Lava5Gregorio P. Milani6Pediatric Institute of Southern Switzerland, Ospedale San Giovanni, Ente Ospedaliero Cantonale, 6500 Bellinzona, SwitzerlandFamily Medicine Institute, Faculty of Biomedical Sciences, Università della Svizzera Italiana, 6900 Lugano, SwitzerlandPediatric Institute of Southern Switzerland, Ospedale San Giovanni, Ente Ospedaliero Cantonale, 6500 Bellinzona, SwitzerlandPediatric Institute of Southern Switzerland, Ospedale San Giovanni, Ente Ospedaliero Cantonale, 6500 Bellinzona, SwitzerlandPediatric Institute of Southern Switzerland, Ospedale San Giovanni, Ente Ospedaliero Cantonale, 6500 Bellinzona, SwitzerlandPediatric Cardiology Unit, Department of Pediatrics, Centre Hospitalier Universitaire Vaudois, University of Lausanne, 1011 Lausanne, SwitzerlandPediatric Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyAcute hemorrhagic edema of young children, a benign skin-limited vasculitis, predominantly affects children 2 years of age or younger. The prevalence and clinical features of the Köbner and Pastia signs have never been systematically investigated in this vasculitis. To address this issue, we analyzed the data contained in the Acute Hemorrhagic Edema Bibliographic Database, which incorporates all reports on hemorrhagic edema published after 1969. A total of 339 cases (236 males and 103 females; 11 (8–18) months of age; median and interquartile range) were documented with at least 1 photograph and therefore included in this analysis. The Köbner sign occurred in 24 cases (14 males and 10 females; 11 (7–17) months of age), the Pastia sign in 51 cases (39 males and 12 females; 11 (8–15) months of age), and both Köbner and Pastia signs in 8 cases (7 males and 1 female; 11 (7–17) months of age). The lower legs, thighs, waistline, and groin were the regions that were most commonly affected with the Köbner sign, while the ankle, feet, cubital fossa, and elbow were most affected with the Pastia sign. The Köbner and Pastia signs are clinically relevant; they occur in about every fourth child affected with hemorrhagic edema and do not influence the disease progression.https://www.mdpi.com/2227-9067/9/2/265acute hemorrhagic edemacockade purpuraFinkelstein–Seidlmayer syndromeinfantile Henoch–Schönlein syndromeKöbner signleukocytoclastic vasculitis |
| spellingShingle | Gabriel Bronz Danilo Consolascio Mario G. Bianchetti Pietro O. Rinoldi Céline Betti Sebastiano A. G. Lava Gregorio P. Milani Köbner and Pastia Signs in Acute Hemorrhagic Edema of Young Children: Systematic Literature Review Children acute hemorrhagic edema cockade purpura Finkelstein–Seidlmayer syndrome infantile Henoch–Schönlein syndrome Köbner sign leukocytoclastic vasculitis |
| title | Köbner and Pastia Signs in Acute Hemorrhagic Edema of Young Children: Systematic Literature Review |
| title_full | Köbner and Pastia Signs in Acute Hemorrhagic Edema of Young Children: Systematic Literature Review |
| title_fullStr | Köbner and Pastia Signs in Acute Hemorrhagic Edema of Young Children: Systematic Literature Review |
| title_full_unstemmed | Köbner and Pastia Signs in Acute Hemorrhagic Edema of Young Children: Systematic Literature Review |
| title_short | Köbner and Pastia Signs in Acute Hemorrhagic Edema of Young Children: Systematic Literature Review |
| title_sort | kobner and pastia signs in acute hemorrhagic edema of young children systematic literature review |
| topic | acute hemorrhagic edema cockade purpura Finkelstein–Seidlmayer syndrome infantile Henoch–Schönlein syndrome Köbner sign leukocytoclastic vasculitis |
| url | https://www.mdpi.com/2227-9067/9/2/265 |
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