Normal Retinotopy in Primary Visual Cortex in a Congenital Complete Unilateral Lesion of Lateral Geniculate Nucleus in Human: A Case Study
Impairment of the geniculostriate pathway results in scotomas in the corresponding part of the visual field. Here, we present a case of patient IB with left eye microphthalmia and with lesions in most of the left geniculostriate pathway, including the Lateral Geniculate Nucleus (LGN). Despite the se...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-01-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/3/1055 |
| _version_ | 1797487677693493248 |
|---|---|
| author | Akshatha Bhat Jan W. Kurzawski Giovanni Anobile Francesca Tinelli Laura Biagi Maria Concetta Morrone |
| author_facet | Akshatha Bhat Jan W. Kurzawski Giovanni Anobile Francesca Tinelli Laura Biagi Maria Concetta Morrone |
| author_sort | Akshatha Bhat |
| collection | DOAJ |
| description | Impairment of the geniculostriate pathway results in scotomas in the corresponding part of the visual field. Here, we present a case of patient IB with left eye microphthalmia and with lesions in most of the left geniculostriate pathway, including the Lateral Geniculate Nucleus (LGN). Despite the severe lesions, the patient has a very narrow scotoma in the peripheral part of the lower-right-hemifield only (beyond 15° of eccentricity) and complete visual field representation in the primary visual cortex. Population receptive field mapping (pRF) of the patient’s visual field reveals orderly eccentricity maps together with contralateral activation in both hemispheres. With diffusion tractography, we revealed connections between superior colliculus (SC) and cortical structures in the hemisphere affected by the lesions, which could mediate the retinotopic reorganization at the cortical level. Our results indicate an astonishing case for the flexibility of the developing retinotopic maps where the contralateral thalamus receives fibers from both the nasal and temporal retinae. |
| first_indexed | 2024-03-09T23:51:10Z |
| format | Article |
| id | doaj.art-e778118c62c64c7a8e17d46ced5bdd4e |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T23:51:10Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e778118c62c64c7a8e17d46ced5bdd4e2023-11-23T16:34:13ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-01-01233105510.3390/ijms23031055Normal Retinotopy in Primary Visual Cortex in a Congenital Complete Unilateral Lesion of Lateral Geniculate Nucleus in Human: A Case StudyAkshatha Bhat0Jan W. Kurzawski1Giovanni Anobile2Francesca Tinelli3Laura Biagi4Maria Concetta Morrone5IRCCS Stella Maris, 56128 Pisa, ItalyIRCCS Stella Maris, 56128 Pisa, ItalyIRCCS Stella Maris, 56128 Pisa, ItalyIRCCS Stella Maris, 56128 Pisa, ItalyIRCCS Stella Maris, 56128 Pisa, ItalyIRCCS Stella Maris, 56128 Pisa, ItalyImpairment of the geniculostriate pathway results in scotomas in the corresponding part of the visual field. Here, we present a case of patient IB with left eye microphthalmia and with lesions in most of the left geniculostriate pathway, including the Lateral Geniculate Nucleus (LGN). Despite the severe lesions, the patient has a very narrow scotoma in the peripheral part of the lower-right-hemifield only (beyond 15° of eccentricity) and complete visual field representation in the primary visual cortex. Population receptive field mapping (pRF) of the patient’s visual field reveals orderly eccentricity maps together with contralateral activation in both hemispheres. With diffusion tractography, we revealed connections between superior colliculus (SC) and cortical structures in the hemisphere affected by the lesions, which could mediate the retinotopic reorganization at the cortical level. Our results indicate an astonishing case for the flexibility of the developing retinotopic maps where the contralateral thalamus receives fibers from both the nasal and temporal retinae.https://www.mdpi.com/1422-0067/23/3/1055microphthalmiavisual plasticitypopulation receptive field mappingBOLD retinotopytractography of visual pathways |
| spellingShingle | Akshatha Bhat Jan W. Kurzawski Giovanni Anobile Francesca Tinelli Laura Biagi Maria Concetta Morrone Normal Retinotopy in Primary Visual Cortex in a Congenital Complete Unilateral Lesion of Lateral Geniculate Nucleus in Human: A Case Study International Journal of Molecular Sciences microphthalmia visual plasticity population receptive field mapping BOLD retinotopy tractography of visual pathways |
| title | Normal Retinotopy in Primary Visual Cortex in a Congenital Complete Unilateral Lesion of Lateral Geniculate Nucleus in Human: A Case Study |
| title_full | Normal Retinotopy in Primary Visual Cortex in a Congenital Complete Unilateral Lesion of Lateral Geniculate Nucleus in Human: A Case Study |
| title_fullStr | Normal Retinotopy in Primary Visual Cortex in a Congenital Complete Unilateral Lesion of Lateral Geniculate Nucleus in Human: A Case Study |
| title_full_unstemmed | Normal Retinotopy in Primary Visual Cortex in a Congenital Complete Unilateral Lesion of Lateral Geniculate Nucleus in Human: A Case Study |
| title_short | Normal Retinotopy in Primary Visual Cortex in a Congenital Complete Unilateral Lesion of Lateral Geniculate Nucleus in Human: A Case Study |
| title_sort | normal retinotopy in primary visual cortex in a congenital complete unilateral lesion of lateral geniculate nucleus in human a case study |
| topic | microphthalmia visual plasticity population receptive field mapping BOLD retinotopy tractography of visual pathways |
| url | https://www.mdpi.com/1422-0067/23/3/1055 |
| work_keys_str_mv | AT akshathabhat normalretinotopyinprimaryvisualcortexinacongenitalcompleteunilaterallesionoflateralgeniculatenucleusinhumanacasestudy AT janwkurzawski normalretinotopyinprimaryvisualcortexinacongenitalcompleteunilaterallesionoflateralgeniculatenucleusinhumanacasestudy AT giovannianobile normalretinotopyinprimaryvisualcortexinacongenitalcompleteunilaterallesionoflateralgeniculatenucleusinhumanacasestudy AT francescatinelli normalretinotopyinprimaryvisualcortexinacongenitalcompleteunilaterallesionoflateralgeniculatenucleusinhumanacasestudy AT laurabiagi normalretinotopyinprimaryvisualcortexinacongenitalcompleteunilaterallesionoflateralgeniculatenucleusinhumanacasestudy AT mariaconcettamorrone normalretinotopyinprimaryvisualcortexinacongenitalcompleteunilaterallesionoflateralgeniculatenucleusinhumanacasestudy |