Transcription factor 7-like 2 rs7903146 polymorphism and therapeutic response to sulfonylureas in patients with type 2 diabetes
Background Transcription factor 7-like 2 (TCF7L2) variations were related to a modified hypoglycemic reaction to sulfonylureas (SUs) in patients with type 2 diabetes mellitus (T2D). Aims The aim of the present work was to show the relationship between TCF7L2 rs7903146 polymorphism and the hypoglycem...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
General Organization of Teaching Hospitals and Institutes
2018-01-01
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| Series: | Journal of Medicine in Scientific Research |
| Subjects: | |
| Online Access: | http://www.jmsr.eg.net/article.asp?issn=2537-091X;year=2018;volume=1;issue=3;spage=168;epage=172;aulast=Omar |
| _version_ | 1797229145151766528 |
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| author | Ghada A Omar Ola Sayed M. Ali Ashraf A Ismail Ghada S Mohamed |
| author_facet | Ghada A Omar Ola Sayed M. Ali Ashraf A Ismail Ghada S Mohamed |
| author_sort | Ghada A Omar |
| collection | DOAJ |
| description | Background
Transcription factor 7-like 2 (TCF7L2) variations were related to a modified hypoglycemic reaction to sulfonylureas (SUs) in patients with type 2 diabetes mellitus (T2D).
Aims
The aim of the present work was to show the relationship between TCF7L2 rs7903146 polymorphism and the hypoglycemic reaction to SUs in T2D patients.
Patients and methods
We enlisted 54 already diagnosed T2D patients who were treated with SUs. Utilizing secondary SU treatment failure, defined as glycated hemoglobin more than 7%, they were divided into two groups: responders and nonresponders. We genotyped the TCF7L2 rs7903146 single-nucleotide polymorphism by utilizing TaqMan allelic discrimination assay-based real-time PCR.
Result
A relationship between the TCF7L2 rs7903146 genotypes TT, CC, CT and therapeutic response to SUs in T2D patients was assessed. In the nonresponders group, the most frequent genotype was the TT (P=0.038) and the most frequent allele was T (P=0.034). Binary logistic regression analysis showed predictors to failure of SUs treatment, providing that TCF7L2 rs7903146 was the significant factor. The TT genotype showed a statistically significant association with nonresponse to SUs, about 4.6 times more than the rest of the genotypes (CC or CT) [P=0.029; odds ratio (OR), 4.643; 95% confidence interval, 1.175–18.355]. The distribution of TCF7L2 rs7903146 alleles was found to be statistically significant, with the OR indicating that the nonresponder status was 2.291 times greater for T allele as opposed to C allele (P=0.034; OR, 2.29; 95% confidence interval, 1.059–4.959). The other factors as sex, age, and duration of the disease were not statistically significant (P=0.334, 0.267, and 0.242, respectively).
Conclusion
TCF7L2 rs7903146 variant was associated with therapeutic response to SUs and it was observed that the most frequent allele in the nonresponders group was the T allele, whereas the most frequent allele in the responders group was the C allele. |
| first_indexed | 2024-04-24T15:07:56Z |
| format | Article |
| id | doaj.art-e7789d59f0f5441897836bc364edfdd5 |
| institution | Directory Open Access Journal |
| issn | 2537-091X 2537-0928 |
| language | English |
| last_indexed | 2024-04-24T15:07:56Z |
| publishDate | 2018-01-01 |
| publisher | General Organization of Teaching Hospitals and Institutes |
| record_format | Article |
| series | Journal of Medicine in Scientific Research |
| spelling | doaj.art-e7789d59f0f5441897836bc364edfdd52024-04-02T12:38:46ZengGeneral Organization of Teaching Hospitals and InstitutesJournal of Medicine in Scientific Research2537-091X2537-09282018-01-011316817210.4103/JMISR.JMISR_43_18Transcription factor 7-like 2 rs7903146 polymorphism and therapeutic response to sulfonylureas in patients with type 2 diabetesGhada A OmarOla Sayed M. AliAshraf A IsmailGhada S MohamedBackground Transcription factor 7-like 2 (TCF7L2) variations were related to a modified hypoglycemic reaction to sulfonylureas (SUs) in patients with type 2 diabetes mellitus (T2D). Aims The aim of the present work was to show the relationship between TCF7L2 rs7903146 polymorphism and the hypoglycemic reaction to SUs in T2D patients. Patients and methods We enlisted 54 already diagnosed T2D patients who were treated with SUs. Utilizing secondary SU treatment failure, defined as glycated hemoglobin more than 7%, they were divided into two groups: responders and nonresponders. We genotyped the TCF7L2 rs7903146 single-nucleotide polymorphism by utilizing TaqMan allelic discrimination assay-based real-time PCR. Result A relationship between the TCF7L2 rs7903146 genotypes TT, CC, CT and therapeutic response to SUs in T2D patients was assessed. In the nonresponders group, the most frequent genotype was the TT (P=0.038) and the most frequent allele was T (P=0.034). Binary logistic regression analysis showed predictors to failure of SUs treatment, providing that TCF7L2 rs7903146 was the significant factor. The TT genotype showed a statistically significant association with nonresponse to SUs, about 4.6 times more than the rest of the genotypes (CC or CT) [P=0.029; odds ratio (OR), 4.643; 95% confidence interval, 1.175–18.355]. The distribution of TCF7L2 rs7903146 alleles was found to be statistically significant, with the OR indicating that the nonresponder status was 2.291 times greater for T allele as opposed to C allele (P=0.034; OR, 2.29; 95% confidence interval, 1.059–4.959). The other factors as sex, age, and duration of the disease were not statistically significant (P=0.334, 0.267, and 0.242, respectively). Conclusion TCF7L2 rs7903146 variant was associated with therapeutic response to SUs and it was observed that the most frequent allele in the nonresponders group was the T allele, whereas the most frequent allele in the responders group was the C allele.http://www.jmsr.eg.net/article.asp?issn=2537-091X;year=2018;volume=1;issue=3;spage=168;epage=172;aulast=Omarsulfonylureastranscription factor 7-like 2 variantstype 2 diabetes |
| spellingShingle | Ghada A Omar Ola Sayed M. Ali Ashraf A Ismail Ghada S Mohamed Transcription factor 7-like 2 rs7903146 polymorphism and therapeutic response to sulfonylureas in patients with type 2 diabetes Journal of Medicine in Scientific Research sulfonylureas transcription factor 7-like 2 variants type 2 diabetes |
| title | Transcription factor 7-like 2 rs7903146 polymorphism and therapeutic response to sulfonylureas in patients with type 2 diabetes |
| title_full | Transcription factor 7-like 2 rs7903146 polymorphism and therapeutic response to sulfonylureas in patients with type 2 diabetes |
| title_fullStr | Transcription factor 7-like 2 rs7903146 polymorphism and therapeutic response to sulfonylureas in patients with type 2 diabetes |
| title_full_unstemmed | Transcription factor 7-like 2 rs7903146 polymorphism and therapeutic response to sulfonylureas in patients with type 2 diabetes |
| title_short | Transcription factor 7-like 2 rs7903146 polymorphism and therapeutic response to sulfonylureas in patients with type 2 diabetes |
| title_sort | transcription factor 7 like 2 rs7903146 polymorphism and therapeutic response to sulfonylureas in patients with type 2 diabetes |
| topic | sulfonylureas transcription factor 7-like 2 variants type 2 diabetes |
| url | http://www.jmsr.eg.net/article.asp?issn=2537-091X;year=2018;volume=1;issue=3;spage=168;epage=172;aulast=Omar |
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