Viral transduction of primary human lymphoma B cells reveals mechanisms of NOTCH-mediated immune escape
NOTCH mutations are frequent in B cell malignancies. Here the authors use retroviral transduction of primary malignant B cells from Chronic Lymphocytic Leukemia (CLL) and Mantle Cell Lymphoma (MCL) patients to show that NOTCH1/2-mutations facilitate mechanism of immune escape.
Bibliographic Details
| Main Authors: |
Maurizio Mangolini,
Alba Maiques-Diaz,
Stella Charalampopoulou,
Elena Gerhard-Hartmann,
Johannes Bloehdorn,
Andrew Moore,
Giorgia Giachetti,
Junyan Lu,
Valar Nila Roamio Franklin,
Chandra Sekkar Reddy Chilamakuri,
Ilias Moutsopoulos,
Andreas Rosenwald,
Stephan Stilgenbauer,
Thorsten Zenz,
Irina Mohorianu,
Clive D’Santos,
Silvia Deaglio,
Daniel J. Hodson,
Jose I. Martin-Subero,
Ingo Ringshausen |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-10-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-33739-2
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