Viral transduction of primary human lymphoma B cells reveals mechanisms of NOTCH-mediated immune escape
NOTCH mutations are frequent in B cell malignancies. Here the authors use retroviral transduction of primary malignant B cells from Chronic Lymphocytic Leukemia (CLL) and Mantle Cell Lymphoma (MCL) patients to show that NOTCH1/2-mutations facilitate mechanism of immune escape.
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-33739-2 |
| _version_ | 1798028564594950144 |
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| author | Maurizio Mangolini Alba Maiques-Diaz Stella Charalampopoulou Elena Gerhard-Hartmann Johannes Bloehdorn Andrew Moore Giorgia Giachetti Junyan Lu Valar Nila Roamio Franklin Chandra Sekkar Reddy Chilamakuri Ilias Moutsopoulos Andreas Rosenwald Stephan Stilgenbauer Thorsten Zenz Irina Mohorianu Clive D’Santos Silvia Deaglio Daniel J. Hodson Jose I. Martin-Subero Ingo Ringshausen |
| author_facet | Maurizio Mangolini Alba Maiques-Diaz Stella Charalampopoulou Elena Gerhard-Hartmann Johannes Bloehdorn Andrew Moore Giorgia Giachetti Junyan Lu Valar Nila Roamio Franklin Chandra Sekkar Reddy Chilamakuri Ilias Moutsopoulos Andreas Rosenwald Stephan Stilgenbauer Thorsten Zenz Irina Mohorianu Clive D’Santos Silvia Deaglio Daniel J. Hodson Jose I. Martin-Subero Ingo Ringshausen |
| author_sort | Maurizio Mangolini |
| collection | DOAJ |
| description | NOTCH mutations are frequent in B cell malignancies. Here the authors use retroviral transduction of primary malignant B cells from Chronic Lymphocytic Leukemia (CLL) and Mantle Cell Lymphoma (MCL) patients to show that NOTCH1/2-mutations facilitate mechanism of immune escape. |
| first_indexed | 2024-04-11T19:10:15Z |
| format | Article |
| id | doaj.art-e779b836c8e440c8aa0f51dae36441ca |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T19:10:15Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e779b836c8e440c8aa0f51dae36441ca2022-12-22T04:07:39ZengNature PortfolioNature Communications2041-17232022-10-0113112110.1038/s41467-022-33739-2Viral transduction of primary human lymphoma B cells reveals mechanisms of NOTCH-mediated immune escapeMaurizio Mangolini0Alba Maiques-Diaz1Stella Charalampopoulou2Elena Gerhard-Hartmann3Johannes Bloehdorn4Andrew Moore5Giorgia Giachetti6Junyan Lu7Valar Nila Roamio Franklin8Chandra Sekkar Reddy Chilamakuri9Ilias Moutsopoulos10Andreas Rosenwald11Stephan Stilgenbauer12Thorsten Zenz13Irina Mohorianu14Clive D’Santos15Silvia Deaglio16Daniel J. Hodson17Jose I. Martin-Subero18Ingo Ringshausen19Wellcome/MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of CambridgeInstitut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Pathologisches Institut Universität WürzburgDepartment of Internal Medicine III, Division of CLL, Ulm UniversityWellcome/MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of CambridgeWellcome/MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of CambridgeEuropean Molecular Biology Laboratory (EMBL)Cancer Research UK Cambridge Institute, University of CambridgeCancer Research UK Cambridge Institute, University of CambridgeWellcome/MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of CambridgePathologisches Institut Universität WürzburgDepartment of Internal Medicine III, Division of CLL, Ulm UniversityDepartment of Medical Oncology and Hematology, University Hospital Zürich and University of ZürichWellcome/MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of CambridgeCancer Research UK Cambridge Institute, University of CambridgeDepartment of Medical Sciences, University of TurinWellcome/MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of CambridgeInstitut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Wellcome/MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of CambridgeNOTCH mutations are frequent in B cell malignancies. Here the authors use retroviral transduction of primary malignant B cells from Chronic Lymphocytic Leukemia (CLL) and Mantle Cell Lymphoma (MCL) patients to show that NOTCH1/2-mutations facilitate mechanism of immune escape.https://doi.org/10.1038/s41467-022-33739-2 |
| spellingShingle | Maurizio Mangolini Alba Maiques-Diaz Stella Charalampopoulou Elena Gerhard-Hartmann Johannes Bloehdorn Andrew Moore Giorgia Giachetti Junyan Lu Valar Nila Roamio Franklin Chandra Sekkar Reddy Chilamakuri Ilias Moutsopoulos Andreas Rosenwald Stephan Stilgenbauer Thorsten Zenz Irina Mohorianu Clive D’Santos Silvia Deaglio Daniel J. Hodson Jose I. Martin-Subero Ingo Ringshausen Viral transduction of primary human lymphoma B cells reveals mechanisms of NOTCH-mediated immune escape Nature Communications |
| title | Viral transduction of primary human lymphoma B cells reveals mechanisms of NOTCH-mediated immune escape |
| title_full | Viral transduction of primary human lymphoma B cells reveals mechanisms of NOTCH-mediated immune escape |
| title_fullStr | Viral transduction of primary human lymphoma B cells reveals mechanisms of NOTCH-mediated immune escape |
| title_full_unstemmed | Viral transduction of primary human lymphoma B cells reveals mechanisms of NOTCH-mediated immune escape |
| title_short | Viral transduction of primary human lymphoma B cells reveals mechanisms of NOTCH-mediated immune escape |
| title_sort | viral transduction of primary human lymphoma b cells reveals mechanisms of notch mediated immune escape |
| url | https://doi.org/10.1038/s41467-022-33739-2 |
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