Mediating Roles of hsCRP, TNF-α and Adiponectin on the Associations between Body Fat and Fatty Liver Disease among Overweight and Obese Adults
Body fat has been reported to be associated with a higher risk of fatty liver disease (FLD). However, few studies have explored the mediating roles of an inflammatory biomarker or adipokine on the relationships. Here, we examined the potential mediating roles of high sensitivity C-reactive protein (...
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MDPI AG
2021-09-01
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| author | Ming Xie Haokai Tang Feifei Li Si Wu Yanhui Dong Yide Yang Julien Steven Baker Jun Ma |
| author_facet | Ming Xie Haokai Tang Feifei Li Si Wu Yanhui Dong Yide Yang Julien Steven Baker Jun Ma |
| author_sort | Ming Xie |
| collection | DOAJ |
| description | Body fat has been reported to be associated with a higher risk of fatty liver disease (FLD). However, few studies have explored the mediating roles of an inflammatory biomarker or adipokine on the relationships. Here, we examined the potential mediating roles of high sensitivity C-reactive protein (hsCRP), tumor necrosis factor-α (TNF-α) and adiponectin (APN) in relationships between body fat and FLD in overweight and obese adults. Additionally, gender differences will be investigated. In total, 1221 participants aged 19–56 years were included in our study. Body fat percentage was measured with Dual Energy X-ray Absorptiometry (DEXA) and FLD by abdominal ultrasound. Mediation analysis was performed to assess the mediating effect of hsCRP, TNF-α and APN on the associations between BF (%) and FLD by gender differences. We found that hsCRP was significantly associated with body fat percentage in both genders (b = 0.2014, <i>p</i> < 0.0001 and b = 0.1804, <i>p</i> < 0.0001 for male and female, respectively), while hsCRP was associated with FLD only in the female group (b = 0.1609, <i>p</i> = 0.0109) but not in male group (b = 0.4800, <i>p</i> = 0.0603). We observed that hsCRP has a significant mediating effect on the association between body fat percentage and FLD (b = 0.0290, <i>p</i> = 0.0201, mediation ratio: 13.6%) in the female group independent of potential covariates (age, smoking, alcohol drinking and physical activity). TNF-α was not significantly associated with body fat percentage or FLD, with no mediating effect on the association between body fat percentage and FLD in either gender. In conclusion, there is a gender-specific mediation role of hsCRP in the association between body fat and FLD. HsCRP was a potential mediator on the association between adiposity and FLD in the female gender, but not in the male gender. Higher body fat was associated with a higher risk of FLD, and the inflammation level might play a potential mediating role in the association between body fat and FLD among female overweight and obese adults. |
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| last_indexed | 2024-03-10T07:53:42Z |
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| spelling | doaj.art-e779fe91e8304b1cb7248e6d693eb53c2023-11-22T12:05:52ZengMDPI AGBiology2079-77372021-09-0110989510.3390/biology10090895Mediating Roles of hsCRP, TNF-α and Adiponectin on the Associations between Body Fat and Fatty Liver Disease among Overweight and Obese AdultsMing Xie0Haokai Tang1Feifei Li2Si Wu3Yanhui Dong4Yide Yang5Julien Steven Baker6Jun Ma7Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha 410081, ChinaKey Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha 410081, ChinaCentre for Health and Exercise Science Research, Hong Kong Baptist University, Kowloon Tong, Hong Kong 999077, ChinaKey Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha 410081, ChinaInstitute of Child and Adolescent Health, School of Public Health, Peking University Health Science Center, Beijing 100191, ChinaKey Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha 410081, ChinaCentre for Health and Exercise Science Research, Hong Kong Baptist University, Kowloon Tong, Hong Kong 999077, ChinaInstitute of Child and Adolescent Health, School of Public Health, Peking University Health Science Center, Beijing 100191, ChinaBody fat has been reported to be associated with a higher risk of fatty liver disease (FLD). However, few studies have explored the mediating roles of an inflammatory biomarker or adipokine on the relationships. Here, we examined the potential mediating roles of high sensitivity C-reactive protein (hsCRP), tumor necrosis factor-α (TNF-α) and adiponectin (APN) in relationships between body fat and FLD in overweight and obese adults. Additionally, gender differences will be investigated. In total, 1221 participants aged 19–56 years were included in our study. Body fat percentage was measured with Dual Energy X-ray Absorptiometry (DEXA) and FLD by abdominal ultrasound. Mediation analysis was performed to assess the mediating effect of hsCRP, TNF-α and APN on the associations between BF (%) and FLD by gender differences. We found that hsCRP was significantly associated with body fat percentage in both genders (b = 0.2014, <i>p</i> < 0.0001 and b = 0.1804, <i>p</i> < 0.0001 for male and female, respectively), while hsCRP was associated with FLD only in the female group (b = 0.1609, <i>p</i> = 0.0109) but not in male group (b = 0.4800, <i>p</i> = 0.0603). We observed that hsCRP has a significant mediating effect on the association between body fat percentage and FLD (b = 0.0290, <i>p</i> = 0.0201, mediation ratio: 13.6%) in the female group independent of potential covariates (age, smoking, alcohol drinking and physical activity). TNF-α was not significantly associated with body fat percentage or FLD, with no mediating effect on the association between body fat percentage and FLD in either gender. In conclusion, there is a gender-specific mediation role of hsCRP in the association between body fat and FLD. HsCRP was a potential mediator on the association between adiposity and FLD in the female gender, but not in the male gender. Higher body fat was associated with a higher risk of FLD, and the inflammation level might play a potential mediating role in the association between body fat and FLD among female overweight and obese adults.https://www.mdpi.com/2079-7737/10/9/895inflammatory factorobesitymediation analysisbody fat percentagegender difference |
| spellingShingle | Ming Xie Haokai Tang Feifei Li Si Wu Yanhui Dong Yide Yang Julien Steven Baker Jun Ma Mediating Roles of hsCRP, TNF-α and Adiponectin on the Associations between Body Fat and Fatty Liver Disease among Overweight and Obese Adults Biology inflammatory factor obesity mediation analysis body fat percentage gender difference |
| title | Mediating Roles of hsCRP, TNF-α and Adiponectin on the Associations between Body Fat and Fatty Liver Disease among Overweight and Obese Adults |
| title_full | Mediating Roles of hsCRP, TNF-α and Adiponectin on the Associations between Body Fat and Fatty Liver Disease among Overweight and Obese Adults |
| title_fullStr | Mediating Roles of hsCRP, TNF-α and Adiponectin on the Associations between Body Fat and Fatty Liver Disease among Overweight and Obese Adults |
| title_full_unstemmed | Mediating Roles of hsCRP, TNF-α and Adiponectin on the Associations between Body Fat and Fatty Liver Disease among Overweight and Obese Adults |
| title_short | Mediating Roles of hsCRP, TNF-α and Adiponectin on the Associations between Body Fat and Fatty Liver Disease among Overweight and Obese Adults |
| title_sort | mediating roles of hscrp tnf α and adiponectin on the associations between body fat and fatty liver disease among overweight and obese adults |
| topic | inflammatory factor obesity mediation analysis body fat percentage gender difference |
| url | https://www.mdpi.com/2079-7737/10/9/895 |
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