2336 Novel PGF2a synthesis pathway in epithelial ovarian cancer
OBJECTIVES/SPECIFIC AIMS: To understand the role of PGF2a and to characterize a novel cyclooxyrgenase (COX)-independent prostaglandin synthesis pathway in epithelial ovarian cancer. METHODS/STUDY POPULATION: We used high grade epithelial ovarian cancer cell line (OVCAR3) as a model to study our path...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
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Cambridge University Press
2018-06-01
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Series: | Journal of Clinical and Translational Science |
Online Access: | https://www.cambridge.org/core/product/identifier/S2059866118001036/type/journal_article |
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author | Muhan Hu Ekta Tiwary Rebecca Arend Michael Miller |
author_facet | Muhan Hu Ekta Tiwary Rebecca Arend Michael Miller |
author_sort | Muhan Hu |
collection | DOAJ |
description | OBJECTIVES/SPECIFIC AIMS: To understand the role of PGF2a and to characterize a novel cyclooxyrgenase (COX)-independent prostaglandin synthesis pathway in epithelial ovarian cancer. METHODS/STUDY POPULATION: We used high grade epithelial ovarian cancer cell line (OVCAR3) as a model to study our pathway. Our main mode of PGF2a detection is through mass spectrometry. RESULTS/ANTICIPATED RESULTS: Our current results suggest the OVCAR3 cells may synthesize PGF2a independently of COX enzymes. We anticipate this novel pathway may be dependent on the TGFb pathway. DISCUSSION/SIGNIFICANCE OF IMPACT: Understanding the role and synthesis pathway of PGF2a may allow us to uncover a novel therapeutic pathway for high grade ovarian cancer. |
first_indexed | 2024-04-10T04:55:17Z |
format | Article |
id | doaj.art-e77e2e9da4ca4a89b07f2f8d722eb518 |
institution | Directory Open Access Journal |
issn | 2059-8661 |
language | English |
last_indexed | 2024-04-10T04:55:17Z |
publishDate | 2018-06-01 |
publisher | Cambridge University Press |
record_format | Article |
series | Journal of Clinical and Translational Science |
spelling | doaj.art-e77e2e9da4ca4a89b07f2f8d722eb5182023-03-09T12:30:17ZengCambridge University PressJournal of Clinical and Translational Science2059-86612018-06-012222210.1017/cts.2018.1032336 Novel PGF2a synthesis pathway in epithelial ovarian cancerMuhan Hu0Ekta Tiwary1Rebecca Arend2Michael Miller3University of Alabama at BirminghamUniversity of Alabama at BirminghamUniversity of Alabama at BirminghamUniversity of Alabama at BirminghamOBJECTIVES/SPECIFIC AIMS: To understand the role of PGF2a and to characterize a novel cyclooxyrgenase (COX)-independent prostaglandin synthesis pathway in epithelial ovarian cancer. METHODS/STUDY POPULATION: We used high grade epithelial ovarian cancer cell line (OVCAR3) as a model to study our pathway. Our main mode of PGF2a detection is through mass spectrometry. RESULTS/ANTICIPATED RESULTS: Our current results suggest the OVCAR3 cells may synthesize PGF2a independently of COX enzymes. We anticipate this novel pathway may be dependent on the TGFb pathway. DISCUSSION/SIGNIFICANCE OF IMPACT: Understanding the role and synthesis pathway of PGF2a may allow us to uncover a novel therapeutic pathway for high grade ovarian cancer.https://www.cambridge.org/core/product/identifier/S2059866118001036/type/journal_article |
spellingShingle | Muhan Hu Ekta Tiwary Rebecca Arend Michael Miller 2336 Novel PGF2a synthesis pathway in epithelial ovarian cancer Journal of Clinical and Translational Science |
title | 2336 Novel PGF2a synthesis pathway in epithelial ovarian cancer |
title_full | 2336 Novel PGF2a synthesis pathway in epithelial ovarian cancer |
title_fullStr | 2336 Novel PGF2a synthesis pathway in epithelial ovarian cancer |
title_full_unstemmed | 2336 Novel PGF2a synthesis pathway in epithelial ovarian cancer |
title_short | 2336 Novel PGF2a synthesis pathway in epithelial ovarian cancer |
title_sort | 2336 novel pgf2a synthesis pathway in epithelial ovarian cancer |
url | https://www.cambridge.org/core/product/identifier/S2059866118001036/type/journal_article |
work_keys_str_mv | AT muhanhu 2336novelpgf2asynthesispathwayinepithelialovariancancer AT ektatiwary 2336novelpgf2asynthesispathwayinepithelialovariancancer AT rebeccaarend 2336novelpgf2asynthesispathwayinepithelialovariancancer AT michaelmiller 2336novelpgf2asynthesispathwayinepithelialovariancancer |