2336 Novel PGF2a synthesis pathway in epithelial ovarian cancer
OBJECTIVES/SPECIFIC AIMS: To understand the role of PGF2a and to characterize a novel cyclooxyrgenase (COX)-independent prostaglandin synthesis pathway in epithelial ovarian cancer. METHODS/STUDY POPULATION: We used high grade epithelial ovarian cancer cell line (OVCAR3) as a model to study our path...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2018-06-01
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| Series: | Journal of Clinical and Translational Science |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2059866118001036/type/journal_article |
| _version_ | 1811156745710469120 |
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| author | Muhan Hu Ekta Tiwary Rebecca Arend Michael Miller |
| author_facet | Muhan Hu Ekta Tiwary Rebecca Arend Michael Miller |
| author_sort | Muhan Hu |
| collection | DOAJ |
| description | OBJECTIVES/SPECIFIC AIMS: To understand the role of PGF2a and to characterize a novel cyclooxyrgenase (COX)-independent prostaglandin synthesis pathway in epithelial ovarian cancer. METHODS/STUDY POPULATION: We used high grade epithelial ovarian cancer cell line (OVCAR3) as a model to study our pathway. Our main mode of PGF2a detection is through mass spectrometry. RESULTS/ANTICIPATED RESULTS: Our current results suggest the OVCAR3 cells may synthesize PGF2a independently of COX enzymes. We anticipate this novel pathway may be dependent on the TGFb pathway. DISCUSSION/SIGNIFICANCE OF IMPACT: Understanding the role and synthesis pathway of PGF2a may allow us to uncover a novel therapeutic pathway for high grade ovarian cancer. |
| first_indexed | 2024-04-10T04:55:17Z |
| format | Article |
| id | doaj.art-e77e2e9da4ca4a89b07f2f8d722eb518 |
| institution | Directory Open Access Journal |
| issn | 2059-8661 |
| language | English |
| last_indexed | 2024-04-10T04:55:17Z |
| publishDate | 2018-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Clinical and Translational Science |
| spelling | doaj.art-e77e2e9da4ca4a89b07f2f8d722eb5182023-03-09T12:30:17ZengCambridge University PressJournal of Clinical and Translational Science2059-86612018-06-012222210.1017/cts.2018.1032336 Novel PGF2a synthesis pathway in epithelial ovarian cancerMuhan Hu0Ekta Tiwary1Rebecca Arend2Michael Miller3University of Alabama at BirminghamUniversity of Alabama at BirminghamUniversity of Alabama at BirminghamUniversity of Alabama at BirminghamOBJECTIVES/SPECIFIC AIMS: To understand the role of PGF2a and to characterize a novel cyclooxyrgenase (COX)-independent prostaglandin synthesis pathway in epithelial ovarian cancer. METHODS/STUDY POPULATION: We used high grade epithelial ovarian cancer cell line (OVCAR3) as a model to study our pathway. Our main mode of PGF2a detection is through mass spectrometry. RESULTS/ANTICIPATED RESULTS: Our current results suggest the OVCAR3 cells may synthesize PGF2a independently of COX enzymes. We anticipate this novel pathway may be dependent on the TGFb pathway. DISCUSSION/SIGNIFICANCE OF IMPACT: Understanding the role and synthesis pathway of PGF2a may allow us to uncover a novel therapeutic pathway for high grade ovarian cancer.https://www.cambridge.org/core/product/identifier/S2059866118001036/type/journal_article |
| spellingShingle | Muhan Hu Ekta Tiwary Rebecca Arend Michael Miller 2336 Novel PGF2a synthesis pathway in epithelial ovarian cancer Journal of Clinical and Translational Science |
| title | 2336 Novel PGF2a synthesis pathway in epithelial ovarian cancer |
| title_full | 2336 Novel PGF2a synthesis pathway in epithelial ovarian cancer |
| title_fullStr | 2336 Novel PGF2a synthesis pathway in epithelial ovarian cancer |
| title_full_unstemmed | 2336 Novel PGF2a synthesis pathway in epithelial ovarian cancer |
| title_short | 2336 Novel PGF2a synthesis pathway in epithelial ovarian cancer |
| title_sort | 2336 novel pgf2a synthesis pathway in epithelial ovarian cancer |
| url | https://www.cambridge.org/core/product/identifier/S2059866118001036/type/journal_article |
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