Genetic liability to asthma and risk of cardiovascular diseases: A Mendelian randomization study
Background and Aims: Epidemiological studies have suggested positive associations between asthma and the risk of cardiovascular diseases (CVDs). However, causality remains inconclusive. We aim to explore the causal associations between asthma and CVDs risk using the Mendelian Randomization (MR) appr...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.879468/full |
| _version_ | 1818013354321510400 |
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| author | Heng Chen Wei Chen Liangrong Zheng |
| author_facet | Heng Chen Wei Chen Liangrong Zheng |
| author_sort | Heng Chen |
| collection | DOAJ |
| description | Background and Aims: Epidemiological studies have suggested positive associations between asthma and the risk of cardiovascular diseases (CVDs). However, causality remains inconclusive. We aim to explore the causal associations between asthma and CVDs risk using the Mendelian Randomization (MR) approach.Methods: We obtained summary-level data for eight CVDs [including atrial fibrillation (AF), coronary artery disease (CAD), heart failure (HF), stroke, ischemic stroke, large artery stroke, small vessel stroke, and cardioembolic stroke] from several large genome-wide association studies (GWASs) and the FinnGen consortium. Nine lead single-nucleotide polymorphisms associated with asthma (p < 5 × 10−8) were identified from the GWAS conducted by the Trans-National Asthma Genetic Consortium. MR analyses were performed using the inverse variance weighted method, supplemented by the weighted median and MR-Egger methods.Results: Inverse variance weighted method showed suggestive effects of genetically determined asthma on AF (odds ratio (OR), 1.08; 95% confidence interval (CI), 1.02, 1.14; p = 0.009) and HF (OR, 1.05; 95% CI, 1.01, 1.09; p = 0.029). We found no causal associations between asthma and other CVDs. No horizontal pleiotropy was observed.Conclusion: This MR study provides genetic evidence suggesting a causal association between asthma and the risk of AF and HF, although not at the level of significance after multiple testing correction. Programs aimed at treating asthma among asthmatics might help prevent the adverse health effects inflicted by CVDs. |
| first_indexed | 2024-04-14T06:32:08Z |
| format | Article |
| id | doaj.art-e77eebd6326441c790efbc11d8300783 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-14T06:32:08Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-e77eebd6326441c790efbc11d83007832022-12-22T02:07:35ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-07-011310.3389/fgene.2022.879468879468Genetic liability to asthma and risk of cardiovascular diseases: A Mendelian randomization studyHeng Chen0Wei Chen1Liangrong Zheng2Department of Cardiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Respiratory and Critical Care Medicine, Ruian People’s Hospital, Wenzhou, ChinaDepartment of Cardiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaBackground and Aims: Epidemiological studies have suggested positive associations between asthma and the risk of cardiovascular diseases (CVDs). However, causality remains inconclusive. We aim to explore the causal associations between asthma and CVDs risk using the Mendelian Randomization (MR) approach.Methods: We obtained summary-level data for eight CVDs [including atrial fibrillation (AF), coronary artery disease (CAD), heart failure (HF), stroke, ischemic stroke, large artery stroke, small vessel stroke, and cardioembolic stroke] from several large genome-wide association studies (GWASs) and the FinnGen consortium. Nine lead single-nucleotide polymorphisms associated with asthma (p < 5 × 10−8) were identified from the GWAS conducted by the Trans-National Asthma Genetic Consortium. MR analyses were performed using the inverse variance weighted method, supplemented by the weighted median and MR-Egger methods.Results: Inverse variance weighted method showed suggestive effects of genetically determined asthma on AF (odds ratio (OR), 1.08; 95% confidence interval (CI), 1.02, 1.14; p = 0.009) and HF (OR, 1.05; 95% CI, 1.01, 1.09; p = 0.029). We found no causal associations between asthma and other CVDs. No horizontal pleiotropy was observed.Conclusion: This MR study provides genetic evidence suggesting a causal association between asthma and the risk of AF and HF, although not at the level of significance after multiple testing correction. Programs aimed at treating asthma among asthmatics might help prevent the adverse health effects inflicted by CVDs.https://www.frontiersin.org/articles/10.3389/fgene.2022.879468/fullMendelian randomizationcausal associationasthmaatrial fibrillationheart failurecoronary artery disease |
| spellingShingle | Heng Chen Wei Chen Liangrong Zheng Genetic liability to asthma and risk of cardiovascular diseases: A Mendelian randomization study Frontiers in Genetics Mendelian randomization causal association asthma atrial fibrillation heart failure coronary artery disease |
| title | Genetic liability to asthma and risk of cardiovascular diseases: A Mendelian randomization study |
| title_full | Genetic liability to asthma and risk of cardiovascular diseases: A Mendelian randomization study |
| title_fullStr | Genetic liability to asthma and risk of cardiovascular diseases: A Mendelian randomization study |
| title_full_unstemmed | Genetic liability to asthma and risk of cardiovascular diseases: A Mendelian randomization study |
| title_short | Genetic liability to asthma and risk of cardiovascular diseases: A Mendelian randomization study |
| title_sort | genetic liability to asthma and risk of cardiovascular diseases a mendelian randomization study |
| topic | Mendelian randomization causal association asthma atrial fibrillation heart failure coronary artery disease |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.879468/full |
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