<i>LLGL2</i> Inhibits Ovarian Cancer Metastasis by Regulating Cytoskeleton Remodeling via <i>ACTN1</i>

<i>LLGL2</i> Inhibits Ovarian Cancer Metastasis by Regulating Cytoskeleton Remodeling via <i>ACTN1</i>

Epithelial ovarian cancer is the most lethal gynecological malignant tumor. Although debulking surgery, chemotherapy, and PARP inhibitors have greatly improved survival, the prognosis for patients with advanced EOC without HRD is still poor. <i>LLGL2</i>, as a cell polarity factor, is in...

Full description

Bibliographic Details
Main Authors:	Qiu-Ying Gu, Yue-Xi Liu, Jin-Long Wang, Xiao-Lan Huang, Ruo-Nan Li, Hua Linghu
Format:	Article
Language:	English
Published:	MDPI AG 2023-12-01
Series:	Cancers
Subjects:	<i>LLGL2</i> ovarian cancer tumor metastasis F-actin <i>ACTN1</i>
Online Access:	https://www.mdpi.com/2072-6694/15/24/5880

Similar Items

Muscle Work and Its Relationship with <i>ACE</i> and <i>ACTN3</i> Polymorphisms Are Associated with the Improvement of Explosive Strength
by: Alberto Melián Ortiz, et al.
Published: (2021-07-01)

A Pilot Study on the Prediction of Non-Contact Muscle Injuries Based on <i>ACTN3</i> R577X and <i>ACE</i> I/D Polymorphisms in Professional Soccer Athletes
by: Kathleen Y. de Almeida, et al.
Published: (2022-11-01)

The Relationship between <i>ACE</i>, <i>ACTN3</i> and <i>MCT1</i> Genetic Polymorphisms and Athletic Performance in Elite Rugby Union Players: A Preliminary Study
by: Massimo Pasqualetti, et al.
Published: (2022-05-01)

Silencing of LLGL2 Suppresses the Estradiol-Induced BPH-1 Cell Proliferation through the Regulation of Autophagy
by: Kyung-Hyun Kim, et al.
Published: (2022-08-01)

<i>ACTN3</i> XX Genotype Negatively Affects Running Performance and Increases Muscle Injury Incidence in <i>LaLiga</i> Football Players
by: Juan Del Coso, et al.
Published: (2024-03-01)

MiR-665 Promotes the Biological Behavior of Small Cell Lung Cancer by Targeting LLGL1
by: Rongfeng LIU, et al.
Published: (2020-04-01)

Association of the <i>ACTN3</i> Gene’s Single-Nucleotide Variant Rs1815739 (R577X) with Sports Qualification and Competitive Distance in Caucasian Athletes of the Southern Urals
by: Olga V. Balberova, et al.
Published: (2023-07-01)

RNF38 suppress growth and metastasis via ubiquitination of ACTN4 in nasopharyngeal carcinoma
by: Cheng Lin, et al.
Published: (2022-05-01)

Greater muscle damage in athletes with ACTN3 R577X (RS1815739) gene polymorphism after an ultra-endurance race: a pilot study
by: T Belli, et al.
Published: (2017-01-01)

The Cytoskeleton and Its Roles in Self-Organization Phenomena: Insights from <i>Xenopus</i> Egg Extracts
by: Zachary M. Geisterfer, et al.
Published: (2021-08-01)

LLGL2 Increases Ca2+ Influx and Exerts Oncogenic Activities via PI3K/AKT Signaling Pathway in Hepatocellular Carcinoma
by: Shusheng Leng, et al.
Published: (2021-06-01)

Direct inhibition of ACTN4 by ellagic acid limits breast cancer metastasis via regulation of β-catenin stabilization in cancer stem cells
by: Neng Wang, et al.
Published: (2017-12-01)

<i>Mn-XRN1</i> Has an Inhibitory Effect on Ovarian Reproduction in <i>Macrobrachium nipponense</i>
by: Tianyong Chen, et al.
Published: (2023-07-01)

Novel Insights into the Wattle and Daub Model of <i>Entamoeba</i> Cyst Wall Formation and the Importance of Actin Cytoskeleton
by: Deepak Krishnan, et al.
Published: (2023-12-01)

SOX2 inhibits LLGL2 polarity protein in esophageal squamous cell carcinoma via miRNA-142-3p
by: Shihui Zhang, et al.
Published: (2022-12-01)

WAVE2 is associated with poor prognosis in pancreatic cancers and promotes cell motility and invasiveness via binding to ACTN4
by: Keisuke Taniuchi, et al.
Published: (2018-11-01)

Recurrent Mutations in <i>BRCA1</i>, <i>BRCA2</i>, <i>RAD51C</i>, <i>PALB2</i> and <i>CHEK2</i> in Polish Patients with Ovarian Cancer
by: Alicja Łukomska, et al.
Published: (2021-02-01)

Investigating the Role of <i>FoxP3</i> in Renal Cell Carcinoma Metastasis with <i>BAP1</i> or <i>SEDT2</i> Mutation
by: Shan Xu, et al.
Published: (2023-08-01)

The Association of ACTN3 Rs1815739 Polymorphism with Various Malocclusion Phenotype
by: Hussain Nihad Izaddin Alalim, et al.
Published: (2022-06-01)

<i>BRCA1</i> and Metastasis: Outcome of Defective DNA Repair
by: Rehna Krishnan, et al.
Published: (2021-12-01)

<i>AtRAC7/ROP9</i> Small GTPase Regulates <i>A. thaliana</i> Immune Systems in Response to <i>B. cinerea</i> Infection
by: Ivette García-Soto, et al.
Published: (2024-01-01)

Tubo-Ovarian Abscess with <i>Actinomyces odontolyticus</i>: Case Report and Brief Review of Literature
by: Adrian Gabriel Pană, et al.
Published: (2022-11-01)

No association between ACTN3 R577X and ACE I/D polymorphisms and endurance running times in 698 Caucasian athletes
by: Ioannis D. Papadimitriou, et al.
Published: (2018-01-01)

A Comparative Study of the Role of Formins in <i>Drosophila</i> Embryonic Dorsal Closure
by: Krisztina Tóth, et al.
Published: (2022-05-01)

A <i>NOTCH1</i> Mutation Found in a Newly Established Ovarian Cancer Cell Line (FDOVL) Promotes Lymph Node Metastasis in Ovarian Cancer
by: Wei Jiang, et al.
Published: (2023-03-01)

Modulation of Cytoskeleton, Protein Trafficking, and Signaling Pathways by Metabolites from <i>Cucurbitaceae</i>, <i>Ericaceae,</i> and <i>Rosaceae</i> Plant Families
by: Ankit Patel, et al.
Published: (2022-11-01)

Role of Actin Dynamics and <i>GhACTIN1</i> Gene in Cotton Fiber Development: A Prototypical Cell for Study
by: Adnan Iqbal, et al.
Published: (2023-08-01)

<i>Let-7i</i> Reduces Aggressive Phenotype and Induces <i>BRCAness</i> in Ovarian Cancer Cells
by: Evgeny Chirshev, et al.
Published: (2021-09-01)

Exercise muscle damage: the role of ACTN3 gene polymorphism
by: E. V. Orekhovskaya, et al.
Published: (2020-09-01)

ACTN3: More than Just a Gene for Speed
by: Craig Pickering, et al.
Published: (2017-12-01)

Differential Expression of <i>BOC</i>, <i>SPOCK2</i>, and <i>GJD3</i> Is Associated with Brain Metastasis of ER-Negative Breast Cancers
by: Rute M. S. M. Pedrosa, et al.
Published: (2021-06-01)

Potential Involvement of <i>ewsr1-w</i> Gene in Ovarian Development of Chinese Tongue Sole, <i>Cynoglossus semilaevis</i>
by: Peng Cheng, et al.
Published: (2022-09-01)

New Insights into Long Non-Coding RNA <i>MALAT1</i> in Cancer and Metastasis
by: Yutong Sun, et al.
Published: (2019-02-01)

ACTN3, Morbidity, and Healthy Aging
by: Craig Pickering, et al.
Published: (2018-01-01)

ACTN3 GENOTYPE IS ASSOCIATED WITH TESTOSTERONE LEVELS OF ATHLETES
by: I.I. Ahmetov, et al.
Published: (2014-07-01)

Real-World Concordance between Germline and Tumour <i>BRCA1/2</i> Status in Epithelial Ovarian Cancer
by: Robert D. Morgan, et al.
Published: (2023-12-01)

<i>MUTYH</i> as an Emerging Predictive Biomarker in Ovarian Cancer
by: Megan L. Hutchcraft, et al.
Published: (2021-01-01)

No Association of Early-Onset Breast or Ovarian Cancer with Early-Onset Cancer in Relatives in <i>BRCA1</i> or <i>BRCA2</i> Mutation Families
by: Marion Imbert-Bouteille, et al.
Published: (2021-07-01)

Interactome and F-Actin Interaction Analysis of <i>Dictyostelium discoideum</i> Coronin A
by: Tohnyui Ndinyanka Fabrice, et al.
Published: (2020-02-01)

Transcriptome Patterns of <i>BRCA1</i>- and <i>BRCA2</i>- Mutated Breast and Ovarian Cancers
by: Arsen Arakelyan, et al.
Published: (2021-01-01)