Antimicrobial Stewardship and Dose Adjustment of Restricted Antimicrobial Drugs in Hospital Setting
Antimicrobial consumption is increasing. In order to maximize the effectiveness of antimicrobial stewardship and provide safe and optimal use of restricted antimicrobial drugs, renal dosing should be evaluated. The aim of this study was to determine the prevalence of restricted antimicrobial drugs t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Pharmacy |
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| Online Access: | https://www.mdpi.com/2226-4787/11/2/68 |
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| author | Iva Vlak Ivana Samardžić Ivana Marinović Nikolina Bušić Vesna Bačić Vrca |
| author_facet | Iva Vlak Ivana Samardžić Ivana Marinović Nikolina Bušić Vesna Bačić Vrca |
| author_sort | Iva Vlak |
| collection | DOAJ |
| description | Antimicrobial consumption is increasing. In order to maximize the effectiveness of antimicrobial stewardship and provide safe and optimal use of restricted antimicrobial drugs, renal dosing should be evaluated. The aim of this study was to determine the prevalence of restricted antimicrobial drugs that required dose adjustment according to renal function. A retrospective, consecutive study was conducted at University Hospital Dubrava. This study analyzed requests for restricted antimicrobial drugs (n = 2890) during a 3-month period. Requests for antimicrobial agents were evaluated by the antimicrobial therapy management team (A-team). This study included 412 restricted antimicrobial drug requests requiring dose adjustment, of which 39.1% did not have an adjusted dose. Meropenem, Ciprofloxacin, Piperacillin/Tazobactam, Vancomycin, Colistin and the antimycotic Fluconazole were the most frequent restricted antimicrobial drugs that required dose adjustment according to impaired renal function. The results of this research highlight the importance of the A-team in the optimization of restricted antimicrobial therapy. Non-adjusted doses of restricted antimicrobial drugs increase the possibility of adverse drug reactions and therefore jeopardize pharmacotherapy outcomes and patient safety. |
| first_indexed | 2024-03-11T04:37:47Z |
| format | Article |
| id | doaj.art-e7832ed3fab843a3b7b250ae821fa6dc |
| institution | Directory Open Access Journal |
| issn | 2226-4787 |
| language | English |
| last_indexed | 2024-03-11T04:37:47Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmacy |
| spelling | doaj.art-e7832ed3fab843a3b7b250ae821fa6dc2023-11-17T20:56:14ZengMDPI AGPharmacy2226-47872023-04-011126810.3390/pharmacy11020068Antimicrobial Stewardship and Dose Adjustment of Restricted Antimicrobial Drugs in Hospital SettingIva Vlak0Ivana Samardžić1Ivana Marinović2Nikolina Bušić3Vesna Bačić Vrca4Department of Clinical Pharmacy, University Hospital Dubrava, 10000 Zagreb, CroatiaDepartment of Clinical Pharmacy, University Hospital Dubrava, 10000 Zagreb, CroatiaDepartment of Clinical Pharmacy, University Hospital Dubrava, 10000 Zagreb, CroatiaDepartment of Hospital Infections and Antimicrobial Stewardship, University Hospital Dubrava, 10000 Zagreb, CroatiaDepartment of Clinical Pharmacy, University Hospital Dubrava, 10000 Zagreb, CroatiaAntimicrobial consumption is increasing. In order to maximize the effectiveness of antimicrobial stewardship and provide safe and optimal use of restricted antimicrobial drugs, renal dosing should be evaluated. The aim of this study was to determine the prevalence of restricted antimicrobial drugs that required dose adjustment according to renal function. A retrospective, consecutive study was conducted at University Hospital Dubrava. This study analyzed requests for restricted antimicrobial drugs (n = 2890) during a 3-month period. Requests for antimicrobial agents were evaluated by the antimicrobial therapy management team (A-team). This study included 412 restricted antimicrobial drug requests requiring dose adjustment, of which 39.1% did not have an adjusted dose. Meropenem, Ciprofloxacin, Piperacillin/Tazobactam, Vancomycin, Colistin and the antimycotic Fluconazole were the most frequent restricted antimicrobial drugs that required dose adjustment according to impaired renal function. The results of this research highlight the importance of the A-team in the optimization of restricted antimicrobial therapy. Non-adjusted doses of restricted antimicrobial drugs increase the possibility of adverse drug reactions and therefore jeopardize pharmacotherapy outcomes and patient safety.https://www.mdpi.com/2226-4787/11/2/68Antimicrobial stewardshiprestricted antimicrobial drugsdose adjustmentadverse drug reactions |
| spellingShingle | Iva Vlak Ivana Samardžić Ivana Marinović Nikolina Bušić Vesna Bačić Vrca Antimicrobial Stewardship and Dose Adjustment of Restricted Antimicrobial Drugs in Hospital Setting Pharmacy Antimicrobial stewardship restricted antimicrobial drugs dose adjustment adverse drug reactions |
| title | Antimicrobial Stewardship and Dose Adjustment of Restricted Antimicrobial Drugs in Hospital Setting |
| title_full | Antimicrobial Stewardship and Dose Adjustment of Restricted Antimicrobial Drugs in Hospital Setting |
| title_fullStr | Antimicrobial Stewardship and Dose Adjustment of Restricted Antimicrobial Drugs in Hospital Setting |
| title_full_unstemmed | Antimicrobial Stewardship and Dose Adjustment of Restricted Antimicrobial Drugs in Hospital Setting |
| title_short | Antimicrobial Stewardship and Dose Adjustment of Restricted Antimicrobial Drugs in Hospital Setting |
| title_sort | antimicrobial stewardship and dose adjustment of restricted antimicrobial drugs in hospital setting |
| topic | Antimicrobial stewardship restricted antimicrobial drugs dose adjustment adverse drug reactions |
| url | https://www.mdpi.com/2226-4787/11/2/68 |
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