Systematic Review on Pathophysiological Complications in Severe COVID-19 among the Non-Vaccinated and Vaccinated Population
COVID-19, caused by SARS-CoV-2, is one of the longest viral pandemics in the history of mankind, which have caused millions of deaths globally and induced severe deformities in the survivals. For instance, fibrosis and cavities in the infected lungs of COVID-19 are some of the complications observed...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-06-01
|
| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/10/7/985 |
| _version_ | 1797433077394309120 |
|---|---|
| author | Ali A. Rabaan Muhammed A. Bakhrebah Abbas Al Mutair Saad Alhumaid Jumana M. Al-Jishi Jehad AlSihati Hawra Albayat Ahmed Alsheheri Mohammed Aljeldah Mohammed Garout Wadha A. Alfouzan Yousef N. Alhashem Salma AlBahrani Saleh A. Alshamrani Sultan Alotaibi Abdullah A. AlRamadhan Hanadi N. Albasha Khalid Hajissa Mohamad-Hani Temsah |
| author_facet | Ali A. Rabaan Muhammed A. Bakhrebah Abbas Al Mutair Saad Alhumaid Jumana M. Al-Jishi Jehad AlSihati Hawra Albayat Ahmed Alsheheri Mohammed Aljeldah Mohammed Garout Wadha A. Alfouzan Yousef N. Alhashem Salma AlBahrani Saleh A. Alshamrani Sultan Alotaibi Abdullah A. AlRamadhan Hanadi N. Albasha Khalid Hajissa Mohamad-Hani Temsah |
| author_sort | Ali A. Rabaan |
| collection | DOAJ |
| description | COVID-19, caused by SARS-CoV-2, is one of the longest viral pandemics in the history of mankind, which have caused millions of deaths globally and induced severe deformities in the survivals. For instance, fibrosis and cavities in the infected lungs of COVID-19 are some of the complications observed in infected patients post COVID-19 recovery. These health abnormalities, including is multiple organ failure—the most striking pathological features of COVID-19—have been linked with diverse distribution of ACE2 receptor. Additionally, several health complications reports were reported after administration of COVID-19 vaccines in healthy individuals, but clinical or molecular pathways causing such complications are not yet studied in detail. Thus, the present systematic review established the comparison of health complication noted in vaccinated and non-vaccinated individuals (COVID-19 infected patients) to identify the association between vaccination and the multiorgan failure based on the data obtained from case studies, research articles, clinical trials/Cohort based studies and review articles published between 2020–2022. This review also includes the biological rationale behind the COVID-19 infection and its subsequent symptoms and effects including multiorgan failure. In addition, multisystem inflammatory syndrome (MIS) has been informed in individuals post vaccination that resulted in multiorgan failure but, no direct correlation of vaccination with MIS has been established. Similarly, hemophagocytic lymphohistiocytosis (HLH) also noted to cause multiorgan failure in some individuals following full vaccination. Furthermore, severe complications were recorded in elderly patients (+40 years of age), indicates that older age individuals are higher risk by COVID-19 and post vaccination, but available literature is not sufficient to comply with any conclusive statements on relationship between vaccination and multiorgan failure. |
| first_indexed | 2024-03-09T10:10:58Z |
| format | Article |
| id | doaj.art-e7833b93e775477f8a96b91add5247b6 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T10:10:58Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-e7833b93e775477f8a96b91add5247b62023-12-01T22:45:58ZengMDPI AGVaccines2076-393X2022-06-0110798510.3390/vaccines10070985Systematic Review on Pathophysiological Complications in Severe COVID-19 among the Non-Vaccinated and Vaccinated PopulationAli A. Rabaan0Muhammed A. Bakhrebah1Abbas Al Mutair2Saad Alhumaid3Jumana M. Al-Jishi4Jehad AlSihati5Hawra Albayat6Ahmed Alsheheri7Mohammed Aljeldah8Mohammed Garout9Wadha A. Alfouzan10Yousef N. Alhashem11Salma AlBahrani12Saleh A. Alshamrani13Sultan Alotaibi14Abdullah A. AlRamadhan15Hanadi N. Albasha16Khalid Hajissa17Mohamad-Hani Temsah18Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran 31311, Saudi ArabiaLife Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 11442, Saudi ArabiaResearch Center, Almoosa Specialist Hospital, Al-Ahsa 36342, Saudi ArabiaAdministration of Pharmaceutical Care, Al-Ahsa Health Cluster, Ministry of Health, Al-Ahsa 31982, Saudi ArabiaInternal Medicine Department, Qatif Central Hospital, Qatif 32654, Saudi ArabiaInternal Medicine Department, Gastroenterology Section, King Fahad Specialist Hospital, Dammam 31311, Saudi ArabiaInfectious Disease Department, King Saud Medical City, Riyadh 7790, Saudi ArabiaInfectious Disease Department, King Saud Medical City, Riyadh 7790, Saudi ArabiaDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, University of Hafr Al Batin, Hafr Al Batin 39524, Saudi ArabiaDepartment of Community Medicine and Health Care for Pilgrims, Faculty of Medicine, Umm Al-Qura University, Makkah 21955, Saudi ArabiaDepartment of Microbiology, Faculty of Medicine, Kuwait University, Safat 13110, KuwaitDepartment of Clinical Laboratory Sciences, Mohammed AlMana College of Health Sciences, Dammam 34222, Saudi ArabiaInfectious Disease Unit, Specialty Internal Medicine, King Fahd Military Medical Complex, Dhahran 31932, Saudi ArabiaDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Najran University, Najran 61441, Saudi ArabiaMolecular Microbiology Department, King Fahad Medical City, Riyadh 11525, Saudi ArabiaLaboratory and Toxicology Department, Security Forces Specialized Comprehensive Clinics, Al-Ahsa 36441, Saudi ArabiaDepartment of Infection Prevention and Control, Obeid Specialized Hospital, Riyadh 12627, Saudi ArabiaDepartment of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, MalaysiaPediatric Department, College of Medicine, King Saud University, Riyadh 11451, Saudi ArabiaCOVID-19, caused by SARS-CoV-2, is one of the longest viral pandemics in the history of mankind, which have caused millions of deaths globally and induced severe deformities in the survivals. For instance, fibrosis and cavities in the infected lungs of COVID-19 are some of the complications observed in infected patients post COVID-19 recovery. These health abnormalities, including is multiple organ failure—the most striking pathological features of COVID-19—have been linked with diverse distribution of ACE2 receptor. Additionally, several health complications reports were reported after administration of COVID-19 vaccines in healthy individuals, but clinical or molecular pathways causing such complications are not yet studied in detail. Thus, the present systematic review established the comparison of health complication noted in vaccinated and non-vaccinated individuals (COVID-19 infected patients) to identify the association between vaccination and the multiorgan failure based on the data obtained from case studies, research articles, clinical trials/Cohort based studies and review articles published between 2020–2022. This review also includes the biological rationale behind the COVID-19 infection and its subsequent symptoms and effects including multiorgan failure. In addition, multisystem inflammatory syndrome (MIS) has been informed in individuals post vaccination that resulted in multiorgan failure but, no direct correlation of vaccination with MIS has been established. Similarly, hemophagocytic lymphohistiocytosis (HLH) also noted to cause multiorgan failure in some individuals following full vaccination. Furthermore, severe complications were recorded in elderly patients (+40 years of age), indicates that older age individuals are higher risk by COVID-19 and post vaccination, but available literature is not sufficient to comply with any conclusive statements on relationship between vaccination and multiorgan failure.https://www.mdpi.com/2076-393X/10/7/985SARS-CoV-2COVID-19multiorgan failurevaccinationmultisystem inflammatory syndromeACE2 receptor |
| spellingShingle | Ali A. Rabaan Muhammed A. Bakhrebah Abbas Al Mutair Saad Alhumaid Jumana M. Al-Jishi Jehad AlSihati Hawra Albayat Ahmed Alsheheri Mohammed Aljeldah Mohammed Garout Wadha A. Alfouzan Yousef N. Alhashem Salma AlBahrani Saleh A. Alshamrani Sultan Alotaibi Abdullah A. AlRamadhan Hanadi N. Albasha Khalid Hajissa Mohamad-Hani Temsah Systematic Review on Pathophysiological Complications in Severe COVID-19 among the Non-Vaccinated and Vaccinated Population Vaccines SARS-CoV-2 COVID-19 multiorgan failure vaccination multisystem inflammatory syndrome ACE2 receptor |
| title | Systematic Review on Pathophysiological Complications in Severe COVID-19 among the Non-Vaccinated and Vaccinated Population |
| title_full | Systematic Review on Pathophysiological Complications in Severe COVID-19 among the Non-Vaccinated and Vaccinated Population |
| title_fullStr | Systematic Review on Pathophysiological Complications in Severe COVID-19 among the Non-Vaccinated and Vaccinated Population |
| title_full_unstemmed | Systematic Review on Pathophysiological Complications in Severe COVID-19 among the Non-Vaccinated and Vaccinated Population |
| title_short | Systematic Review on Pathophysiological Complications in Severe COVID-19 among the Non-Vaccinated and Vaccinated Population |
| title_sort | systematic review on pathophysiological complications in severe covid 19 among the non vaccinated and vaccinated population |
| topic | SARS-CoV-2 COVID-19 multiorgan failure vaccination multisystem inflammatory syndrome ACE2 receptor |
| url | https://www.mdpi.com/2076-393X/10/7/985 |
| work_keys_str_mv | AT aliarabaan systematicreviewonpathophysiologicalcomplicationsinseverecovid19amongthenonvaccinatedandvaccinatedpopulation AT muhammedabakhrebah systematicreviewonpathophysiologicalcomplicationsinseverecovid19amongthenonvaccinatedandvaccinatedpopulation AT abbasalmutair systematicreviewonpathophysiologicalcomplicationsinseverecovid19amongthenonvaccinatedandvaccinatedpopulation AT saadalhumaid systematicreviewonpathophysiologicalcomplicationsinseverecovid19amongthenonvaccinatedandvaccinatedpopulation AT jumanamaljishi systematicreviewonpathophysiologicalcomplicationsinseverecovid19amongthenonvaccinatedandvaccinatedpopulation AT jehadalsihati systematicreviewonpathophysiologicalcomplicationsinseverecovid19amongthenonvaccinatedandvaccinatedpopulation AT hawraalbayat systematicreviewonpathophysiologicalcomplicationsinseverecovid19amongthenonvaccinatedandvaccinatedpopulation AT ahmedalsheheri systematicreviewonpathophysiologicalcomplicationsinseverecovid19amongthenonvaccinatedandvaccinatedpopulation AT mohammedaljeldah systematicreviewonpathophysiologicalcomplicationsinseverecovid19amongthenonvaccinatedandvaccinatedpopulation AT mohammedgarout systematicreviewonpathophysiologicalcomplicationsinseverecovid19amongthenonvaccinatedandvaccinatedpopulation AT wadhaaalfouzan systematicreviewonpathophysiologicalcomplicationsinseverecovid19amongthenonvaccinatedandvaccinatedpopulation AT yousefnalhashem systematicreviewonpathophysiologicalcomplicationsinseverecovid19amongthenonvaccinatedandvaccinatedpopulation AT salmaalbahrani systematicreviewonpathophysiologicalcomplicationsinseverecovid19amongthenonvaccinatedandvaccinatedpopulation AT salehaalshamrani systematicreviewonpathophysiologicalcomplicationsinseverecovid19amongthenonvaccinatedandvaccinatedpopulation AT sultanalotaibi systematicreviewonpathophysiologicalcomplicationsinseverecovid19amongthenonvaccinatedandvaccinatedpopulation AT abdullahaalramadhan systematicreviewonpathophysiologicalcomplicationsinseverecovid19amongthenonvaccinatedandvaccinatedpopulation AT hanadinalbasha systematicreviewonpathophysiologicalcomplicationsinseverecovid19amongthenonvaccinatedandvaccinatedpopulation AT khalidhajissa systematicreviewonpathophysiologicalcomplicationsinseverecovid19amongthenonvaccinatedandvaccinatedpopulation AT mohamadhanitemsah systematicreviewonpathophysiologicalcomplicationsinseverecovid19amongthenonvaccinatedandvaccinatedpopulation |