Action Mechanisms of Curcumin in Alzheimer’s Disease and Its Brain Targeted Delivery
AD is a chronic neurodegenerative disease. Many different signaling pathways, such as Wnt/β-catenin, Notch, ROS/JNK, and PI3K/Akt/mTOR are involved in Alzheimer’s disease and crosstalk between themselves. A promising treatment involves the uses of flavonoids, and one of the most promising is curcumi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Materials |
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| Online Access: | https://www.mdpi.com/1996-1944/14/12/3332 |
| _version_ | 1797529934321680384 |
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| author | Duygu Ege |
| author_facet | Duygu Ege |
| author_sort | Duygu Ege |
| collection | DOAJ |
| description | AD is a chronic neurodegenerative disease. Many different signaling pathways, such as Wnt/β-catenin, Notch, ROS/JNK, and PI3K/Akt/mTOR are involved in Alzheimer’s disease and crosstalk between themselves. A promising treatment involves the uses of flavonoids, and one of the most promising is curcumin; however, because it has difficulty permeating the blood–brain barrier (BBB), it must be encapsulated by a drug carrier. Some of the most frequently studied are lipid nanocarriers, liposomes, micelles and PLGA. These carriers are further conjugated with brain-targeting agents such as lactoferrin and transferrin. In this review paper, curcumin and its therapeutic effects, which have been examined in vivo, are analyzed and then the delivery systems to the brain are addressed. Overall, the analysis of the literature revealed great potential for curcumin in treating AD and indicated the challenges that require further research. |
| first_indexed | 2024-03-10T10:21:57Z |
| format | Article |
| id | doaj.art-e7858e64329247a195ad92be326d66d1 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T10:21:57Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-e7858e64329247a195ad92be326d66d12023-11-22T00:23:57ZengMDPI AGMaterials1996-19442021-06-011412333210.3390/ma14123332Action Mechanisms of Curcumin in Alzheimer’s Disease and Its Brain Targeted DeliveryDuygu Ege0Biomedical Engineering, Boğaziçi University, Rasathane Cd, Kandilli Campus, Istanbul 34684, TurkeyAD is a chronic neurodegenerative disease. Many different signaling pathways, such as Wnt/β-catenin, Notch, ROS/JNK, and PI3K/Akt/mTOR are involved in Alzheimer’s disease and crosstalk between themselves. A promising treatment involves the uses of flavonoids, and one of the most promising is curcumin; however, because it has difficulty permeating the blood–brain barrier (BBB), it must be encapsulated by a drug carrier. Some of the most frequently studied are lipid nanocarriers, liposomes, micelles and PLGA. These carriers are further conjugated with brain-targeting agents such as lactoferrin and transferrin. In this review paper, curcumin and its therapeutic effects, which have been examined in vivo, are analyzed and then the delivery systems to the brain are addressed. Overall, the analysis of the literature revealed great potential for curcumin in treating AD and indicated the challenges that require further research.https://www.mdpi.com/1996-1944/14/12/3332ADcurcuminlipid-based carriersPLGAin vivodrug delivery |
| spellingShingle | Duygu Ege Action Mechanisms of Curcumin in Alzheimer’s Disease and Its Brain Targeted Delivery Materials AD curcumin lipid-based carriers PLGA in vivo drug delivery |
| title | Action Mechanisms of Curcumin in Alzheimer’s Disease and Its Brain Targeted Delivery |
| title_full | Action Mechanisms of Curcumin in Alzheimer’s Disease and Its Brain Targeted Delivery |
| title_fullStr | Action Mechanisms of Curcumin in Alzheimer’s Disease and Its Brain Targeted Delivery |
| title_full_unstemmed | Action Mechanisms of Curcumin in Alzheimer’s Disease and Its Brain Targeted Delivery |
| title_short | Action Mechanisms of Curcumin in Alzheimer’s Disease and Its Brain Targeted Delivery |
| title_sort | action mechanisms of curcumin in alzheimer s disease and its brain targeted delivery |
| topic | AD curcumin lipid-based carriers PLGA in vivo drug delivery |
| url | https://www.mdpi.com/1996-1944/14/12/3332 |
| work_keys_str_mv | AT duyguege actionmechanismsofcurcumininalzheimersdiseaseanditsbraintargeteddelivery |