<i>Salmonella</i> Enteritidis Fatal Septicemia with Meningoencephalitis in a Tiger (<i>Panthera tigris</i>) Cub
A 15-day-old, female, captive <i>Panthera tigris</i> cub was hospitalized after developing severe hyperthermia, depression, and lack of appetite. The clinical condition rapidly worsened, and the tiger cub died in 72 h after the onset of neurological symptoms, septic shock, and multiple o...
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MDPI AG
2022-09-01
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| Online Access: | https://www.mdpi.com/2076-2615/12/19/2490 |
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| author | Elisa Mazzotta Greta Foiani Giulia Maria De Benedictis Enrico Fiore Alda Natale Elena Spagnolo Marta Vascellari Giulia Cento Michela Corrò |
| author_facet | Elisa Mazzotta Greta Foiani Giulia Maria De Benedictis Enrico Fiore Alda Natale Elena Spagnolo Marta Vascellari Giulia Cento Michela Corrò |
| author_sort | Elisa Mazzotta |
| collection | DOAJ |
| description | A 15-day-old, female, captive <i>Panthera tigris</i> cub was hospitalized after developing severe hyperthermia, depression, and lack of appetite. The clinical condition rapidly worsened, and the tiger cub died in 72 h after the onset of neurological symptoms, septic shock, and multiple organ dysfunction syndrome. The postmortem main gross findings consisted of a severe and diffuse bilateral fibrino-suppurative meningoencephalitis and ventriculitis, mild fibrinous and sero-hemorrhagic polyserositis and cystitis, severe pulmonary edema, and hemorrhages. Microscopically, the meninges, ependyma, and choroid plexuses were diffusely expanded by abundant infiltration of neutrophils and macrophages, with multifocal fibrinous exudation. Histiocytic interstitial pneumonia, fibrinous and neutrophilic polyserositis, and pyelocystitis were also observed. Vascular thrombosis with multifocal vasculitis and vascular necrosis were frequently observed. Aerobic and anaerobic cultures performed on the brain, lungs, intestine, kidneys, and in pericardial effusion reported the presence of <i>Salmonella enterica</i> subsp. <i>enterica</i> serovar Enteritidis. Environmental and nutritional contamination were identified as putative sources of infections. To the best of the authors’ knowledge, this is the first report of <i>Salmonella</i> Enteritidis septicemia with meningoencephalitis in a tiger cub, which highlights the need to further investigate the cause of acute perinatal death to reduce the risk of infectious disease outbreaks. |
| first_indexed | 2024-03-09T22:09:53Z |
| format | Article |
| id | doaj.art-e7859bfdefdb4f9883549b3d287dd610 |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-09T22:09:53Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-e7859bfdefdb4f9883549b3d287dd6102023-11-23T19:34:27ZengMDPI AGAnimals2076-26152022-09-011219249010.3390/ani12192490<i>Salmonella</i> Enteritidis Fatal Septicemia with Meningoencephalitis in a Tiger (<i>Panthera tigris</i>) CubElisa Mazzotta0Greta Foiani1Giulia Maria De Benedictis2Enrico Fiore3Alda Natale4Elena Spagnolo5Marta Vascellari6Giulia Cento7Michela Corrò8Diagnostics in Animal Health Department, Istituto Zooprofilattico Sperimentale delle Venezie, Viale dell’Università 10, 35020 Legnaro, ItalySpecialist Diagnostics, Histopathology and Parasitology Department, Istituto Zooprofilattico Sperimentale delle Venezie, Viale dell’Università 10, 35020 Legnaro, ItalyDepartment of Animal Medicine, Productions and Health (MAPS), University of Padua, Viale dell’Università 12, 35020 Legnaro, ItalyDepartment of Animal Medicine, Productions and Health (MAPS), University of Padua, Viale dell’Università 12, 35020 Legnaro, ItalyDiagnostics in Animal Health Department, Istituto Zooprofilattico Sperimentale delle Venezie, Viale dell’Università 10, 35020 Legnaro, ItalyDiagnostics in Animal Health Department, Istituto Zooprofilattico Sperimentale delle Venezie, Viale dell’Università 10, 35020 Legnaro, ItalySpecialist Diagnostics, Histopathology and Parasitology Department, Istituto Zooprofilattico Sperimentale delle Venezie, Viale dell’Università 10, 35020 Legnaro, ItalyWOAH and National Reference Laboratory for Salmonellosis, Istituto Zooprofilattico Sperimentale delle Venezie, Viale dell’Università 10, 35020 Legnaro, ItalyDiagnostics in Animal Health Department, Istituto Zooprofilattico Sperimentale delle Venezie, Viale dell’Università 10, 35020 Legnaro, ItalyA 15-day-old, female, captive <i>Panthera tigris</i> cub was hospitalized after developing severe hyperthermia, depression, and lack of appetite. The clinical condition rapidly worsened, and the tiger cub died in 72 h after the onset of neurological symptoms, septic shock, and multiple organ dysfunction syndrome. The postmortem main gross findings consisted of a severe and diffuse bilateral fibrino-suppurative meningoencephalitis and ventriculitis, mild fibrinous and sero-hemorrhagic polyserositis and cystitis, severe pulmonary edema, and hemorrhages. Microscopically, the meninges, ependyma, and choroid plexuses were diffusely expanded by abundant infiltration of neutrophils and macrophages, with multifocal fibrinous exudation. Histiocytic interstitial pneumonia, fibrinous and neutrophilic polyserositis, and pyelocystitis were also observed. Vascular thrombosis with multifocal vasculitis and vascular necrosis were frequently observed. Aerobic and anaerobic cultures performed on the brain, lungs, intestine, kidneys, and in pericardial effusion reported the presence of <i>Salmonella enterica</i> subsp. <i>enterica</i> serovar Enteritidis. Environmental and nutritional contamination were identified as putative sources of infections. To the best of the authors’ knowledge, this is the first report of <i>Salmonella</i> Enteritidis septicemia with meningoencephalitis in a tiger cub, which highlights the need to further investigate the cause of acute perinatal death to reduce the risk of infectious disease outbreaks.https://www.mdpi.com/2076-2615/12/19/2490salmonellosis<i>Salmonella</i> Enteritidistigersepticemiameningoencephalitispolyserositis |
| spellingShingle | Elisa Mazzotta Greta Foiani Giulia Maria De Benedictis Enrico Fiore Alda Natale Elena Spagnolo Marta Vascellari Giulia Cento Michela Corrò <i>Salmonella</i> Enteritidis Fatal Septicemia with Meningoencephalitis in a Tiger (<i>Panthera tigris</i>) Cub Animals salmonellosis <i>Salmonella</i> Enteritidis tiger septicemia meningoencephalitis polyserositis |
| title | <i>Salmonella</i> Enteritidis Fatal Septicemia with Meningoencephalitis in a Tiger (<i>Panthera tigris</i>) Cub |
| title_full | <i>Salmonella</i> Enteritidis Fatal Septicemia with Meningoencephalitis in a Tiger (<i>Panthera tigris</i>) Cub |
| title_fullStr | <i>Salmonella</i> Enteritidis Fatal Septicemia with Meningoencephalitis in a Tiger (<i>Panthera tigris</i>) Cub |
| title_full_unstemmed | <i>Salmonella</i> Enteritidis Fatal Septicemia with Meningoencephalitis in a Tiger (<i>Panthera tigris</i>) Cub |
| title_short | <i>Salmonella</i> Enteritidis Fatal Septicemia with Meningoencephalitis in a Tiger (<i>Panthera tigris</i>) Cub |
| title_sort | i salmonella i enteritidis fatal septicemia with meningoencephalitis in a tiger i panthera tigris i cub |
| topic | salmonellosis <i>Salmonella</i> Enteritidis tiger septicemia meningoencephalitis polyserositis |
| url | https://www.mdpi.com/2076-2615/12/19/2490 |
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