Preferential tau aggregation in von Economo neurons and fork cells in frontotemporal lobar degeneration with specific MAPT variants

Preferential tau aggregation in von Economo neurons and fork cells in frontotemporal lobar degeneration with specific MAPT variants

Abstract Tau aggregation is a hallmark feature in a subset of patients with frontotemporal dementia (FTD). Early and selective loss of von Economo neurons (VENs) and fork cells within the frontoinsular (FI) and anterior cingulate cortices (ACC) is observed in patients with sporadic behavioral varian...

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Bibliographic Details
Main Authors: Li-Chun Lin, Alissa L. Nana, Mackenzie Hepker, Ji-Hye Lee Hwang, Stephanie E. Gaus, Salvatore Spina, Celica G. Cosme, Li Gan, Lea T. Grinberg, Daniel H. Geschwind, Giovanni Coppola, Howard J. Rosen, Bruce L. Miller, William W. Seeley
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Acta Neuropathologica Communications
Subjects:
Selective vulnerability
Tau
MAPT
von Economo neurons
Anterior cingulate cortex
Insula
Online Access:http://link.springer.com/article/10.1186/s40478-019-0809-0

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