PCSK9 inhibitors in a renal transplant patient complicated with hepatitis B: A case report and literature review
Lipid metabolism disorders are recognized to be one of the most frequent complications of renal transplantation, while dyslipidemia and chronic kidney disease (CKD) are strong risk factors for arteriosclerotic cardiovascular disease (ASCVD). Proprotein convertase subtilisin/kexin type 9 inhibitors (...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.937474/full |
| _version_ | 1811223676649996288 |
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| author | Pinchao Lv Yuxi Li Lin Wu Haoyu Weng Ming Chen Wenhui Ding Jianping Li |
| author_facet | Pinchao Lv Yuxi Li Lin Wu Haoyu Weng Ming Chen Wenhui Ding Jianping Li |
| author_sort | Pinchao Lv |
| collection | DOAJ |
| description | Lipid metabolism disorders are recognized to be one of the most frequent complications of renal transplantation, while dyslipidemia and chronic kidney disease (CKD) are strong risk factors for arteriosclerotic cardiovascular disease (ASCVD). Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) are novel lipid-lowering drugs, the safety and efficacy of which are yet to be confirmed in transplanted patients. There have been several small-sample studies using PCSK9i in patients after heart transplantation, while fewer cases use PCSK9i after kidney transplantation. We report a case of a renal transplant recipient complicated with hepatitis B treated with PCSK9i, which achieved a remarkable lipid-lowering efficacy, and no significant adverse effects were found during the follow-up. |
| first_indexed | 2024-04-12T08:36:46Z |
| format | Article |
| id | doaj.art-e7888ff1cce34b099887cc1d635f4605 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-12T08:36:46Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-e7888ff1cce34b099887cc1d635f46052022-12-22T03:39:59ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-11-01910.3389/fcvm.2022.937474937474PCSK9 inhibitors in a renal transplant patient complicated with hepatitis B: A case report and literature reviewPinchao LvYuxi LiLin WuHaoyu WengMing ChenWenhui DingJianping LiLipid metabolism disorders are recognized to be one of the most frequent complications of renal transplantation, while dyslipidemia and chronic kidney disease (CKD) are strong risk factors for arteriosclerotic cardiovascular disease (ASCVD). Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) are novel lipid-lowering drugs, the safety and efficacy of which are yet to be confirmed in transplanted patients. There have been several small-sample studies using PCSK9i in patients after heart transplantation, while fewer cases use PCSK9i after kidney transplantation. We report a case of a renal transplant recipient complicated with hepatitis B treated with PCSK9i, which achieved a remarkable lipid-lowering efficacy, and no significant adverse effects were found during the follow-up.https://www.frontiersin.org/articles/10.3389/fcvm.2022.937474/fulldyslipidemiarenal transplantationviral hepatitisPCSK9icoronary heart disease |
| spellingShingle | Pinchao Lv Yuxi Li Lin Wu Haoyu Weng Ming Chen Wenhui Ding Jianping Li PCSK9 inhibitors in a renal transplant patient complicated with hepatitis B: A case report and literature review Frontiers in Cardiovascular Medicine dyslipidemia renal transplantation viral hepatitis PCSK9i coronary heart disease |
| title | PCSK9 inhibitors in a renal transplant patient complicated with hepatitis B: A case report and literature review |
| title_full | PCSK9 inhibitors in a renal transplant patient complicated with hepatitis B: A case report and literature review |
| title_fullStr | PCSK9 inhibitors in a renal transplant patient complicated with hepatitis B: A case report and literature review |
| title_full_unstemmed | PCSK9 inhibitors in a renal transplant patient complicated with hepatitis B: A case report and literature review |
| title_short | PCSK9 inhibitors in a renal transplant patient complicated with hepatitis B: A case report and literature review |
| title_sort | pcsk9 inhibitors in a renal transplant patient complicated with hepatitis b a case report and literature review |
| topic | dyslipidemia renal transplantation viral hepatitis PCSK9i coronary heart disease |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.937474/full |
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