Respiratory and peripheral muscle involvement in patients with pulmonary arterial hypertension due to congenital heart diseases
Skeletal and respiratory muscle dysfunction has been previously described in patients with other etiologic subgroups of pulmonary arterial hypertension (PAH) but has never been investigated in patients with PAH due to congenital heart diseases (CHD). This study aims to show the involvement of skelet...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2021-03-01
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| Series: | Monaldi Archives for Chest Disease |
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| Online Access: | https://www.monaldi-archives.org/index.php/macd/article/view/1551 |
| _version_ | 1818876718063026176 |
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| author | Özge Keniş-Coşkun Derya Kocakaya İlker Yağcı Bulent Mutlu Sait Karakurt |
| author_facet | Özge Keniş-Coşkun Derya Kocakaya İlker Yağcı Bulent Mutlu Sait Karakurt |
| author_sort | Özge Keniş-Coşkun |
| collection | DOAJ |
| description | Skeletal and respiratory muscle dysfunction has been previously described in patients with other etiologic subgroups of pulmonary arterial hypertension (PAH) but has never been investigated in patients with PAH due to congenital heart diseases (CHD). This study aims to show the involvement of skeletal and respiratory muscles in these patients. This cross-sectional study included patients with PAH due to CHD and healthy controls. Patients’ demographic properties, six-minute walk tests; shoulder abduction, handgrip, knee extension, and ankle dorsiflexion muscle strength, maximum inspiratory (MIP) and expiratory pressures (MEP) were measured. Deltoid, flexor digitorum superficialis, and profundus, tibialis anterior and rectus femoris muscles were visualized with ultrasonography and their cross-sectional areas (CSA) were also measured in both groups. 12 patients and 12 controls were included. Mean MIP was 104.22±32.57 cm H2O for healthy participants while 61.33±29.74 cm H2O for patients (p<0.001). For mean MEP, it was 100.08±26.05 cm H2O in healthy participants and 69.75±39.79 cmH2O in controls (p=0.004). When the strength of skeletal muscles was compared, there were significant differences between the groups in all measurements except for bilateral grip strength. In the correlation analysis, MIP and MEP values showed no significant correlations with clinical parameters. They showed significant moderate correlations with skeletal muscle strength. When CSAs of the muscles were compared, there were significant differences in all measurements except for left FDS and FDP and bilateral rectus femoris. This study showed that in patients with pulmonary arterial hypertension due to CHD, respiratory muscle strength is significantly worse than healthy participants. Patients had also significantly worse skeletal muscle strength except for grip strength. |
| first_indexed | 2024-12-19T13:46:50Z |
| format | Article |
| id | doaj.art-e7893bbe8c874b6bb204178a5496e947 |
| institution | Directory Open Access Journal |
| issn | 1122-0643 2532-5264 |
| language | English |
| last_indexed | 2024-12-19T13:46:50Z |
| publishDate | 2021-03-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Monaldi Archives for Chest Disease |
| spelling | doaj.art-e7893bbe8c874b6bb204178a5496e9472022-12-21T20:18:50ZengPAGEPress PublicationsMonaldi Archives for Chest Disease1122-06432532-52642021-03-0110.4081/monaldi.2021.1551Respiratory and peripheral muscle involvement in patients with pulmonary arterial hypertension due to congenital heart diseasesÖzge Keniş-Coşkun0Derya Kocakaya1İlker Yağcı2Bulent Mutlu3Sait Karakurt4Physical Medicine and Rehabilitation Department, Marmara University Medical Faculty, Istanbul Pulmonology Department, Marmara University Medical Faculty, IstanbulPhysical Medicine and Rehabilitation Department, Marmara University Medical Faculty, Istanbul Cardiology Department, Marmara University Medical Faculty, IstanbulPulmonology Department, Marmara University Medical Faculty, IstanbulSkeletal and respiratory muscle dysfunction has been previously described in patients with other etiologic subgroups of pulmonary arterial hypertension (PAH) but has never been investigated in patients with PAH due to congenital heart diseases (CHD). This study aims to show the involvement of skeletal and respiratory muscles in these patients. This cross-sectional study included patients with PAH due to CHD and healthy controls. Patients’ demographic properties, six-minute walk tests; shoulder abduction, handgrip, knee extension, and ankle dorsiflexion muscle strength, maximum inspiratory (MIP) and expiratory pressures (MEP) were measured. Deltoid, flexor digitorum superficialis, and profundus, tibialis anterior and rectus femoris muscles were visualized with ultrasonography and their cross-sectional areas (CSA) were also measured in both groups. 12 patients and 12 controls were included. Mean MIP was 104.22±32.57 cm H2O for healthy participants while 61.33±29.74 cm H2O for patients (p<0.001). For mean MEP, it was 100.08±26.05 cm H2O in healthy participants and 69.75±39.79 cmH2O in controls (p=0.004). When the strength of skeletal muscles was compared, there were significant differences between the groups in all measurements except for bilateral grip strength. In the correlation analysis, MIP and MEP values showed no significant correlations with clinical parameters. They showed significant moderate correlations with skeletal muscle strength. When CSAs of the muscles were compared, there were significant differences in all measurements except for left FDS and FDP and bilateral rectus femoris. This study showed that in patients with pulmonary arterial hypertension due to CHD, respiratory muscle strength is significantly worse than healthy participants. Patients had also significantly worse skeletal muscle strength except for grip strength.https://www.monaldi-archives.org/index.php/macd/article/view/1551congenital heart disease, pulmonary hypertension, skeletal muscle, ultrasound |
| spellingShingle | Özge Keniş-Coşkun Derya Kocakaya İlker Yağcı Bulent Mutlu Sait Karakurt Respiratory and peripheral muscle involvement in patients with pulmonary arterial hypertension due to congenital heart diseases Monaldi Archives for Chest Disease congenital heart disease, pulmonary hypertension, skeletal muscle, ultrasound |
| title | Respiratory and peripheral muscle involvement in patients with pulmonary arterial hypertension due to congenital heart diseases |
| title_full | Respiratory and peripheral muscle involvement in patients with pulmonary arterial hypertension due to congenital heart diseases |
| title_fullStr | Respiratory and peripheral muscle involvement in patients with pulmonary arterial hypertension due to congenital heart diseases |
| title_full_unstemmed | Respiratory and peripheral muscle involvement in patients with pulmonary arterial hypertension due to congenital heart diseases |
| title_short | Respiratory and peripheral muscle involvement in patients with pulmonary arterial hypertension due to congenital heart diseases |
| title_sort | respiratory and peripheral muscle involvement in patients with pulmonary arterial hypertension due to congenital heart diseases |
| topic | congenital heart disease, pulmonary hypertension, skeletal muscle, ultrasound |
| url | https://www.monaldi-archives.org/index.php/macd/article/view/1551 |
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