Peripheralization Strategies Applied to Morphinans and Implications for Improved Treatment of Pain

Peripheralization Strategies Applied to Morphinans and Implications for Improved Treatment of Pain

Opioids are considered the most effective analgesics for the treatment of moderate to severe acute and chronic pain. However, the inadequate benefit/risk ratio of currently available opioids, together with the current ‘opioid crisis’, warrant consideration on new opioid analgesic discovery strategie...

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Bibliographic Details
Main Authors: Helmut Schmidhammer, Mahmoud Al-Khrasani, Susanna Fürst, Mariana Spetea
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Molecules
Subjects:
pain
analgesia
opioid receptors
peripheral analgesia
peripherally restricted opioids
morphine
Online Access:https://www.mdpi.com/1420-3049/28/12/4761

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