The Effects of Dietary Polyphenols on Circulating Cardiovascular Disease Biomarkers and Iron Status: A Systematic Review
The prevalence of cardiovascular disease (CVD) is rising worldwide, remaining the major cause of death in developed countries. Polyphenols have been shown to have cardioprotective properties; however, their impact on iron bioavailability and potential impact on other aspects of health is unclear. A...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2019-10-01
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| Series: | Nutrition and Metabolic Insights |
| Online Access: | https://doi.org/10.1177/1178638819882739 |
| _version_ | 1811332730657439744 |
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| author | Hollie Speer Nathan M D’Cunha Michal Botek Andrew J McKune Domenico Sergi Ekavi Georgousopoulou Duane D Mellor Nenad Naumovski |
| author_facet | Hollie Speer Nathan M D’Cunha Michal Botek Andrew J McKune Domenico Sergi Ekavi Georgousopoulou Duane D Mellor Nenad Naumovski |
| author_sort | Hollie Speer |
| collection | DOAJ |
| description | The prevalence of cardiovascular disease (CVD) is rising worldwide, remaining the major cause of death in developed countries. Polyphenols have been shown to have cardioprotective properties; however, their impact on iron bioavailability and potential impact on other aspects of health is unclear. A systematic review was undertaken to evaluate the current status of the relationship between habitual polyphenol consumption, iron status, and circulating biomarkers of CVD. Following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2009 guidelines, searches were performed across 5 electronic databases (PubMed, Cochrane Library, Scopus, Web of Science, and CINAHL) to identify randomized controlled trials which investigated the effects of polyphenol consumption on inflammatory markers, serum lipid profile, and iron absorption and bioavailability. In total, 1174 records were identified, with only 7 studies meeting the inclusion criteria. The selected studies involved 133 participants and used a variety of foods and supplements, including olive oil and cherries, rich in polyphenols including hydroxytyrosol, quercetin, and resveratrol, as well as catechin enriched drinks. The duration of the studies ranged from between 56 and 145 days, with total polyphenolic content of the food items and supplements ranging from 45 to 1015 mg (per 100 g). Polyphenols did not appear to interfere with iron status, and most studies reported improvements in inflammatory markers and lipid profile. While these results are promising, the limited number of studies and considerable heterogeneity across the interventions support the need for more extensive trials assessing the relationship between polyphenol intake, iron bioavailability, and CVD risk. |
| first_indexed | 2024-04-13T16:41:11Z |
| format | Article |
| id | doaj.art-e78b8f0d33724c27896e925f002d155e |
| institution | Directory Open Access Journal |
| issn | 1178-6388 |
| language | English |
| last_indexed | 2024-04-13T16:41:11Z |
| publishDate | 2019-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Nutrition and Metabolic Insights |
| spelling | doaj.art-e78b8f0d33724c27896e925f002d155e2022-12-22T02:39:14ZengSAGE PublishingNutrition and Metabolic Insights1178-63882019-10-011210.1177/1178638819882739The Effects of Dietary Polyphenols on Circulating Cardiovascular Disease Biomarkers and Iron Status: A Systematic ReviewHollie Speer0Nathan M D’Cunha1Michal Botek2Andrew J McKune3Domenico Sergi4Ekavi Georgousopoulou5Duane D Mellor6Nenad Naumovski7Collaborative Research in Bioactives and Biomarkers (CRIBB) Group, University of Canberra, Bruce, ACT, AustraliaCollaborative Research in Bioactives and Biomarkers (CRIBB) Group, University of Canberra, Bruce, ACT, AustraliaDepartment of Natural Sciences in Kinanthropology, Faculty of Physical Culture, Palacký University Olomouc, Olomouc, Czech RepublicDiscipline of Biokinetics, Exercise and Leisure Sciences, School of Health Science, University of KwaZulu-Natal, Durban, South AfricaNutrition & Health Substantiation Group, Nutrition and Health Program, Health and Biosecurity, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Adelaide, SA, AustraliaSchool of Medicine, The University of Notre Dame, Sydney, NSW, AustraliaAston Medical School, Aston University, Birmingham, UKCollaborative Research in Bioactives and Biomarkers (CRIBB) Group, University of Canberra, Bruce, ACT, AustraliaThe prevalence of cardiovascular disease (CVD) is rising worldwide, remaining the major cause of death in developed countries. Polyphenols have been shown to have cardioprotective properties; however, their impact on iron bioavailability and potential impact on other aspects of health is unclear. A systematic review was undertaken to evaluate the current status of the relationship between habitual polyphenol consumption, iron status, and circulating biomarkers of CVD. Following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2009 guidelines, searches were performed across 5 electronic databases (PubMed, Cochrane Library, Scopus, Web of Science, and CINAHL) to identify randomized controlled trials which investigated the effects of polyphenol consumption on inflammatory markers, serum lipid profile, and iron absorption and bioavailability. In total, 1174 records were identified, with only 7 studies meeting the inclusion criteria. The selected studies involved 133 participants and used a variety of foods and supplements, including olive oil and cherries, rich in polyphenols including hydroxytyrosol, quercetin, and resveratrol, as well as catechin enriched drinks. The duration of the studies ranged from between 56 and 145 days, with total polyphenolic content of the food items and supplements ranging from 45 to 1015 mg (per 100 g). Polyphenols did not appear to interfere with iron status, and most studies reported improvements in inflammatory markers and lipid profile. While these results are promising, the limited number of studies and considerable heterogeneity across the interventions support the need for more extensive trials assessing the relationship between polyphenol intake, iron bioavailability, and CVD risk.https://doi.org/10.1177/1178638819882739 |
| spellingShingle | Hollie Speer Nathan M D’Cunha Michal Botek Andrew J McKune Domenico Sergi Ekavi Georgousopoulou Duane D Mellor Nenad Naumovski The Effects of Dietary Polyphenols on Circulating Cardiovascular Disease Biomarkers and Iron Status: A Systematic Review Nutrition and Metabolic Insights |
| title | The Effects of Dietary Polyphenols on Circulating Cardiovascular Disease Biomarkers and Iron Status: A Systematic Review |
| title_full | The Effects of Dietary Polyphenols on Circulating Cardiovascular Disease Biomarkers and Iron Status: A Systematic Review |
| title_fullStr | The Effects of Dietary Polyphenols on Circulating Cardiovascular Disease Biomarkers and Iron Status: A Systematic Review |
| title_full_unstemmed | The Effects of Dietary Polyphenols on Circulating Cardiovascular Disease Biomarkers and Iron Status: A Systematic Review |
| title_short | The Effects of Dietary Polyphenols on Circulating Cardiovascular Disease Biomarkers and Iron Status: A Systematic Review |
| title_sort | effects of dietary polyphenols on circulating cardiovascular disease biomarkers and iron status a systematic review |
| url | https://doi.org/10.1177/1178638819882739 |
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