An Original Method for the Synthesis and Study of the Biological Activity of Natural Lembehyne B Aromatic Analogs
In the development of earlier-initiated studies on the synthesis of natural and synthetic neuritogenic alkynols, lembehynes A–C—which simultaneously exhibit high antitumor activity—we developed a method for the synthesis of an analogue of natural lembehyne B containing a phenyl radical in its struct...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-11-01
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| Series: | Chemistry Proceedings |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-4583/8/1/30 |
| Summary: | In the development of earlier-initiated studies on the synthesis of natural and synthetic neuritogenic alkynols, lembehynes A–C—which simultaneously exhibit high antitumor activity—we developed a method for the synthesis of an analogue of natural lembehyne B containing a phenyl radical in its structure. It is shown that the synthesized aromatic analogue of lembehyne B exhibits higher antitumor activity in vitro than a number of tumor cell lines (Jurkat, K562 and U937). |
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| ISSN: | 2673-4583 |