Choroid plexus and pituitary gland hemochromatosis induced by transfusional iron overload: Two case reports
Hemochromatosis is a primary or secondary pathological condition characterized by the deposition of excess iron in the body tissues, which can eventually lead to cellular damage and organ dysfunction. Although excess iron deposition in the central nervous system is rare, involvement of the choroid p...
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Elsevier
2024-05-01
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| Series: | Radiology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1930043324000608 |
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| author | Hiroyuki Fujii, MD, PhD Mitsuru Matsuki, MD, PhD Takefumi Hamakawa, MD Yumiko Toda, MD Nana Fujii, MD Sota Masuoka, MD Akihiro Nakamata, MD Emiko Chiba, MD, PhD Kazunari Ishii, MD, PhD Harushi Mori, MD, PhD |
| author_facet | Hiroyuki Fujii, MD, PhD Mitsuru Matsuki, MD, PhD Takefumi Hamakawa, MD Yumiko Toda, MD Nana Fujii, MD Sota Masuoka, MD Akihiro Nakamata, MD Emiko Chiba, MD, PhD Kazunari Ishii, MD, PhD Harushi Mori, MD, PhD |
| author_sort | Hiroyuki Fujii, MD, PhD |
| collection | DOAJ |
| description | Hemochromatosis is a primary or secondary pathological condition characterized by the deposition of excess iron in the body tissues, which can eventually lead to cellular damage and organ dysfunction. Although excess iron deposition in the central nervous system is rare, involvement of the choroid plexus, pituitary gland, cortical surfaces, and basal ganglia has been reported to date. This case report describes 2 cases of transfusion-induced hemochromatosis involving the choroid plexus and pituitary gland, which were diagnosed by magnetic resonance imaging (MRI). In both cases, gradient echo (GRE) sequences, such as T2 star-weighted image and susceptibility-weighted imaging demonstrated markedly low signal intensity in the choroid plexus. Furthermore, the pituitary gland showed low signal intensity on T2-weighted images in Patient 2. Because these low signal intensities were not seen prior to red blood cell transfusion, they were diagnosed with transfusion-induced hemochromatosis. Brain MRI with GRE sequences was useful in detecting iron deposition in the choroid plexus. Considering that iron deposition in the body tissues can lead to irreversible organ damage, MRI with GRE sequences should be considered for patients with suspected iron overload. |
| first_indexed | 2024-03-08T02:01:55Z |
| format | Article |
| id | doaj.art-e79045a17d4d49558f1f7aa780c618ca |
| institution | Directory Open Access Journal |
| issn | 1930-0433 |
| language | English |
| last_indexed | 2024-04-25T01:13:07Z |
| publishDate | 2024-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj.art-e79045a17d4d49558f1f7aa780c618ca2024-03-10T05:11:44ZengElsevierRadiology Case Reports1930-04332024-05-0119516661670Choroid plexus and pituitary gland hemochromatosis induced by transfusional iron overload: Two case reportsHiroyuki Fujii, MD, PhD0Mitsuru Matsuki, MD, PhD1Takefumi Hamakawa, MD2Yumiko Toda, MD3Nana Fujii, MD4Sota Masuoka, MD5Akihiro Nakamata, MD6Emiko Chiba, MD, PhD7Kazunari Ishii, MD, PhD8Harushi Mori, MD, PhD9Department of Radiology, Jichi Medical University, Tochigi, Japan; Corresponding author.Department of Pediatric Radiology, Jichi Children's Medical Center Tochigi, JapanDepartment of Radiology, Faculty of Medicine, Kindai University, Osaka-Sayama, JapanDivision of Hematology, Department of Internal Medicine, Jichi Medical University, Tochigi, JapanDepartment of Radiology, Jichi Medical University, Tochigi, JapanDepartment of Radiology, Jichi Medical University, Tochigi, JapanDepartment of Radiology, Jichi Medical University, Tochigi, JapanDepartment of Radiology, Jichi Medical University, Tochigi, JapanDepartment of Radiology, Faculty of Medicine, Kindai University, Osaka-Sayama, JapanDepartment of Radiology, Jichi Medical University, Tochigi, JapanHemochromatosis is a primary or secondary pathological condition characterized by the deposition of excess iron in the body tissues, which can eventually lead to cellular damage and organ dysfunction. Although excess iron deposition in the central nervous system is rare, involvement of the choroid plexus, pituitary gland, cortical surfaces, and basal ganglia has been reported to date. This case report describes 2 cases of transfusion-induced hemochromatosis involving the choroid plexus and pituitary gland, which were diagnosed by magnetic resonance imaging (MRI). In both cases, gradient echo (GRE) sequences, such as T2 star-weighted image and susceptibility-weighted imaging demonstrated markedly low signal intensity in the choroid plexus. Furthermore, the pituitary gland showed low signal intensity on T2-weighted images in Patient 2. Because these low signal intensities were not seen prior to red blood cell transfusion, they were diagnosed with transfusion-induced hemochromatosis. Brain MRI with GRE sequences was useful in detecting iron deposition in the choroid plexus. Considering that iron deposition in the body tissues can lead to irreversible organ damage, MRI with GRE sequences should be considered for patients with suspected iron overload.http://www.sciencedirect.com/science/article/pii/S1930043324000608HemochromatosisIron overloadMRIGradient echoT2 star-weighted imageSusceptibility-weighted image |
| spellingShingle | Hiroyuki Fujii, MD, PhD Mitsuru Matsuki, MD, PhD Takefumi Hamakawa, MD Yumiko Toda, MD Nana Fujii, MD Sota Masuoka, MD Akihiro Nakamata, MD Emiko Chiba, MD, PhD Kazunari Ishii, MD, PhD Harushi Mori, MD, PhD Choroid plexus and pituitary gland hemochromatosis induced by transfusional iron overload: Two case reports Radiology Case Reports Hemochromatosis Iron overload MRI Gradient echo T2 star-weighted image Susceptibility-weighted image |
| title | Choroid plexus and pituitary gland hemochromatosis induced by transfusional iron overload: Two case reports |
| title_full | Choroid plexus and pituitary gland hemochromatosis induced by transfusional iron overload: Two case reports |
| title_fullStr | Choroid plexus and pituitary gland hemochromatosis induced by transfusional iron overload: Two case reports |
| title_full_unstemmed | Choroid plexus and pituitary gland hemochromatosis induced by transfusional iron overload: Two case reports |
| title_short | Choroid plexus and pituitary gland hemochromatosis induced by transfusional iron overload: Two case reports |
| title_sort | choroid plexus and pituitary gland hemochromatosis induced by transfusional iron overload two case reports |
| topic | Hemochromatosis Iron overload MRI Gradient echo T2 star-weighted image Susceptibility-weighted image |
| url | http://www.sciencedirect.com/science/article/pii/S1930043324000608 |
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