Frontotemporal lobar degeneration proteinopathies have disparate microscopic patterns of white and grey matter pathology

Frontotemporal lobar degeneration proteinopathies have disparate microscopic patterns of white and grey matter pathology

Abstract Frontotemporal lobar degeneration proteinopathies with tau inclusions (FTLD-Tau) or TDP-43 inclusions (FTLD-TDP) are associated with clinically similar phenotypes. However, these disparate proteinopathies likely differ in cellular severity and regional distribution of inclusions in white ma...

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Bibliographic Details
Main Authors: Lucia A. A. Giannini, Claire Peterson, Daniel Ohm, Sharon X. Xie, Corey T. McMillan, Katya Raskovsky, Lauren Massimo, EunRah Suh, Vivianna M. Van Deerlin, David A. Wolk, John Q. Trojanowski, Edward B. Lee, Murray Grossman, David J. Irwin
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Acta Neuropathologica Communications
Subjects:
Tau
TDP-43
Frontotemporal dementia
Primary progressive aphasia
Neuropathology
Online Access:https://doi.org/10.1186/s40478-021-01129-2

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