The role of azacitidine in the management of myelodysplastic syndromes (MDS)
KS Götze, C Müller-Thomas, C PeschelDepartment of Medicine, Hematology/Oncology, Technische Universität München, Munich, GermanyAbstract: Myelodysplastic syndromes (MDS) are a group of common bone marrow disorders characterized by ineffective hemat...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2009-10-01
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| Series: | Cancer Management and Research |
| Online Access: | http://www.dovepress.com/the-role-of-azacitidine-in-the-management-of-myelodysplastic-syndromes-a3618 |
| _version_ | 1818806030728953856 |
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| author | KS Götze C Müller-Thomas C Peschel |
| author_facet | KS Götze C Müller-Thomas C Peschel |
| author_sort | KS Götze |
| collection | DOAJ |
| description | KS Götze, C Müller-Thomas, C PeschelDepartment of Medicine, Hematology/Oncology, Technische Universität München, Munich, GermanyAbstract: Myelodysplastic syndromes (MDS) are a group of common bone marrow disorders characterized by ineffective hematopoiesis, peripheral cytopenias, and a propensity for transformation to acute myeloid leukemia (AML). For many years, the main treatment option for MDS was best supportive care which alleviates symptoms but has no effect on the natural course of the disease. The recent approval of the demethylating agent azacitidine represents a significant advance in the treatment of MDS. The results of two randomized trials with azacitidine have shown an overall response rate between 40% and 60%, an improved quality of life, a reduced risk of transformation to AML and a definite survival advantage compared to best supportive care or low-dose chemotherapy. Current data on azacitidine and its place in the treatment of MDS are reviewed.Keywords: myelodysplastic syndromes, MDS, azacitidine, epigenetic therapy, demethyltransferase inhibitor |
| first_indexed | 2024-12-18T19:03:18Z |
| format | Article |
| id | doaj.art-e791bfdce866435098d8755236eb100b |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-18T19:03:18Z |
| publishDate | 2009-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-e791bfdce866435098d8755236eb100b2022-12-21T20:56:28ZengDove Medical PressCancer Management and Research1179-13222009-10-012009default119130The role of azacitidine in the management of myelodysplastic syndromes (MDS)KS GötzeC Müller-ThomasC PeschelKS Götze, C Müller-Thomas, C PeschelDepartment of Medicine, Hematology/Oncology, Technische Universität München, Munich, GermanyAbstract: Myelodysplastic syndromes (MDS) are a group of common bone marrow disorders characterized by ineffective hematopoiesis, peripheral cytopenias, and a propensity for transformation to acute myeloid leukemia (AML). For many years, the main treatment option for MDS was best supportive care which alleviates symptoms but has no effect on the natural course of the disease. The recent approval of the demethylating agent azacitidine represents a significant advance in the treatment of MDS. The results of two randomized trials with azacitidine have shown an overall response rate between 40% and 60%, an improved quality of life, a reduced risk of transformation to AML and a definite survival advantage compared to best supportive care or low-dose chemotherapy. Current data on azacitidine and its place in the treatment of MDS are reviewed.Keywords: myelodysplastic syndromes, MDS, azacitidine, epigenetic therapy, demethyltransferase inhibitorhttp://www.dovepress.com/the-role-of-azacitidine-in-the-management-of-myelodysplastic-syndromes-a3618 |
| spellingShingle | KS Götze C Müller-Thomas C Peschel The role of azacitidine in the management of myelodysplastic syndromes (MDS) Cancer Management and Research |
| title | The role of azacitidine in the management of myelodysplastic syndromes (MDS) |
| title_full | The role of azacitidine in the management of myelodysplastic syndromes (MDS) |
| title_fullStr | The role of azacitidine in the management of myelodysplastic syndromes (MDS) |
| title_full_unstemmed | The role of azacitidine in the management of myelodysplastic syndromes (MDS) |
| title_short | The role of azacitidine in the management of myelodysplastic syndromes (MDS) |
| title_sort | role of azacitidine in the management of myelodysplastic syndromes mds |
| url | http://www.dovepress.com/the-role-of-azacitidine-in-the-management-of-myelodysplastic-syndromes-a3618 |
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