Sphingosine 1-phosphate receptor 2 mediated early stages of pancreatic and systemic inflammatory responses via NF-kappa B activation in acute pancreatitis

Sphingosine 1-phosphate receptor 2 mediated early stages of pancreatic and systemic inflammatory responses via NF-kappa B activation in acute pancreatitis

Abstract In acute pancreatitis, activation of inflammatory signaling, including the nuclear factor-kappa B (NF-κB) pathway, within acinar cells is known to be an early intracellular event occurring in parallel with pathologic trypsinogen activation. Sphingosine 1-phosphate receptor 2 (S1PR2) plays a...

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Bibliographic Details
Main Authors: Jing Yang, Xujiao Tang, Baiqiang Li, Jinsong Shi
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Cell Communication and Signaling
Subjects:
S1PR2
Acute pancreatitis
Inflammatory responses
Acinar cells
NF-kappa B
Online Access:https://doi.org/10.1186/s12964-022-00971-8

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