Choroidal Vascularity Index in Adult-Onset Foveomacular Vitelliform Dystrophy: A Pilot Study
This pilot study aims to investigate choroidal vascular status in eyes with adult-onset foveomacular vitelliform dystrophy (AOFVD), early age-related macular degeneration (AMD), and age-matched controls. In this retrospective study, choroidal thickness (CT) was measured manually using spectral domai...
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MDPI AG
2021-11-01
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| Online Access: | https://www.mdpi.com/2076-3417/11/21/10487 |
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| author | Solmaz Abdolrahimzadeh Serena Fragiotta Chiara Ciacimino Mariachiara Di Pippo Gianluca Scuderi |
| author_facet | Solmaz Abdolrahimzadeh Serena Fragiotta Chiara Ciacimino Mariachiara Di Pippo Gianluca Scuderi |
| author_sort | Solmaz Abdolrahimzadeh |
| collection | DOAJ |
| description | This pilot study aims to investigate choroidal vascular status in eyes with adult-onset foveomacular vitelliform dystrophy (AOFVD), early age-related macular degeneration (AMD), and age-matched controls. In this retrospective study, choroidal thickness (CT) was measured manually using spectral domain optical coherence tomography images of the fovea, and 500 and 1500 µm from the nasal and temporal regions in the fovea. The horizontal B-scan was imported into Fiji software. Choroidal vascularity index (CVI) and luminal and stromal areas were calculated. A total of 36 eyes from 36 patients, including 18 eyes with AOFVD and 18 eyes with CD, and 16 eyes of healthy subjects were included. CVI was significantly different among subgroups (ANOVA, <i>p</i> = 0.004). Eyes with AOFVD presented a higher CVI (+0.03 ± 0.01, <i>p</i> = 0.001) than eyes with CD and controls (<i>p</i> = 0.03). No differences in CVI were detected between controls and eyes with CD (<i>p</i> = 0.25). AOFVD eyes accounted for the greatest luminal area, particularly significant in comparison with healthy controls (+0.27 ± 0.11, <i>p</i> = 0.02). AOFVD eyes present a greater CVI than eyes with CD and controls. The major choroidal involvement is on the luminal component, further corroborating a possible role of the choroidal vasculature in the pathological manifestations of AOFVD disease. |
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| publishDate | 2021-11-01 |
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| series | Applied Sciences |
| spelling | doaj.art-e793737141ff40e8bb66443327890f1c2023-12-03T13:24:23ZengMDPI AGApplied Sciences2076-34172021-11-0111211048710.3390/app112110487Choroidal Vascularity Index in Adult-Onset Foveomacular Vitelliform Dystrophy: A Pilot StudySolmaz Abdolrahimzadeh0Serena Fragiotta1Chiara Ciacimino2Mariachiara Di Pippo3Gianluca Scuderi4Ophthalmology Unit, Neurosciences, Mental Health, and Sensory Organs (NESMOS) Department, Sapienza University of Rome, St. Andrea Hospital, Via di Grottarossa 1035/1039, 00189 Rome, ItalyOphthalmology Unit, Neurosciences, Mental Health, and Sensory Organs (NESMOS) Department, Sapienza University of Rome, St. Andrea Hospital, Via di Grottarossa 1035/1039, 00189 Rome, ItalyOphthalmology Unit, Neurosciences, Mental Health, and Sensory Organs (NESMOS) Department, Sapienza University of Rome, St. Andrea Hospital, Via di Grottarossa 1035/1039, 00189 Rome, ItalyOphthalmology Unit, Neurosciences, Mental Health, and Sensory Organs (NESMOS) Department, Sapienza University of Rome, St. Andrea Hospital, Via di Grottarossa 1035/1039, 00189 Rome, ItalyOphthalmology Unit, Neurosciences, Mental Health, and Sensory Organs (NESMOS) Department, Sapienza University of Rome, St. Andrea Hospital, Via di Grottarossa 1035/1039, 00189 Rome, ItalyThis pilot study aims to investigate choroidal vascular status in eyes with adult-onset foveomacular vitelliform dystrophy (AOFVD), early age-related macular degeneration (AMD), and age-matched controls. In this retrospective study, choroidal thickness (CT) was measured manually using spectral domain optical coherence tomography images of the fovea, and 500 and 1500 µm from the nasal and temporal regions in the fovea. The horizontal B-scan was imported into Fiji software. Choroidal vascularity index (CVI) and luminal and stromal areas were calculated. A total of 36 eyes from 36 patients, including 18 eyes with AOFVD and 18 eyes with CD, and 16 eyes of healthy subjects were included. CVI was significantly different among subgroups (ANOVA, <i>p</i> = 0.004). Eyes with AOFVD presented a higher CVI (+0.03 ± 0.01, <i>p</i> = 0.001) than eyes with CD and controls (<i>p</i> = 0.03). No differences in CVI were detected between controls and eyes with CD (<i>p</i> = 0.25). AOFVD eyes accounted for the greatest luminal area, particularly significant in comparison with healthy controls (+0.27 ± 0.11, <i>p</i> = 0.02). AOFVD eyes present a greater CVI than eyes with CD and controls. The major choroidal involvement is on the luminal component, further corroborating a possible role of the choroidal vasculature in the pathological manifestations of AOFVD disease.https://www.mdpi.com/2076-3417/11/21/10487adult-onset foveomacular vitelliform dystrophyage-related macular degenerationchoroidal thicknesschoroidal vascularity indexconventional drusenspectral domain optical coherence tomography |
| spellingShingle | Solmaz Abdolrahimzadeh Serena Fragiotta Chiara Ciacimino Mariachiara Di Pippo Gianluca Scuderi Choroidal Vascularity Index in Adult-Onset Foveomacular Vitelliform Dystrophy: A Pilot Study Applied Sciences adult-onset foveomacular vitelliform dystrophy age-related macular degeneration choroidal thickness choroidal vascularity index conventional drusen spectral domain optical coherence tomography |
| title | Choroidal Vascularity Index in Adult-Onset Foveomacular Vitelliform Dystrophy: A Pilot Study |
| title_full | Choroidal Vascularity Index in Adult-Onset Foveomacular Vitelliform Dystrophy: A Pilot Study |
| title_fullStr | Choroidal Vascularity Index in Adult-Onset Foveomacular Vitelliform Dystrophy: A Pilot Study |
| title_full_unstemmed | Choroidal Vascularity Index in Adult-Onset Foveomacular Vitelliform Dystrophy: A Pilot Study |
| title_short | Choroidal Vascularity Index in Adult-Onset Foveomacular Vitelliform Dystrophy: A Pilot Study |
| title_sort | choroidal vascularity index in adult onset foveomacular vitelliform dystrophy a pilot study |
| topic | adult-onset foveomacular vitelliform dystrophy age-related macular degeneration choroidal thickness choroidal vascularity index conventional drusen spectral domain optical coherence tomography |
| url | https://www.mdpi.com/2076-3417/11/21/10487 |
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