Cluster headache: state of the art in treatment
Cluster headache (CH) is the most common and devastating autonomic headache with multiple and recent advances in treatment. However, it usually goes unrecognized and is found to have a delayed and inappropriate treatment. This paper aims to review the current therapeutic options for patients with CH...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Pain Research |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpain.2023.1265540/full |
| _version_ | 1797647653280940032 |
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| author | Ildefonso Rodriguez-Leyva Maria-Karina Velez-Jimenez Silvia García Juan Alberto Nader-Kawachi Adriana Patricia Martínez-Mayorga Agustín Melo-Carrillo Humberto Juárez-Jimenez Marco Martinez-Gurrola Manuel Gudiño-Castelazo Erwin Chiquete Jorge Villareal-Careaga Alejandro Marfil Paul David Uribe-Jaimes Rubén Dario Vargas-García Miguel Angel Collado-Ortiz Daniel San-Juan |
| author_facet | Ildefonso Rodriguez-Leyva Maria-Karina Velez-Jimenez Silvia García Juan Alberto Nader-Kawachi Adriana Patricia Martínez-Mayorga Agustín Melo-Carrillo Humberto Juárez-Jimenez Marco Martinez-Gurrola Manuel Gudiño-Castelazo Erwin Chiquete Jorge Villareal-Careaga Alejandro Marfil Paul David Uribe-Jaimes Rubén Dario Vargas-García Miguel Angel Collado-Ortiz Daniel San-Juan |
| author_sort | Ildefonso Rodriguez-Leyva |
| collection | DOAJ |
| description | Cluster headache (CH) is the most common and devastating autonomic headache with multiple and recent advances in treatment. However, it usually goes unrecognized and is found to have a delayed and inappropriate treatment. This paper aims to review the current therapeutic options for patients with CH. We conducted a narrative literature review on the treatments available for this condition using the American Academy of Neurology (AAN) classification of therapeutic evidence. We found effective and safe pharmacological and non-pharmacological therapies with heterogeneity of clinical trial designs for patients with CH, and they are divided into three phases, namely, transitional, acute, and preventive interventions. Prednisone (A) is the most studied treatment in the transitional phase; acute attacks are treated using triptans (A), oxygen (A), and non-invasive transcutaneous vagal nerve stimulation (A). Verapamil (A) and monoclonal antibodies (possible A) are considered the first options in preventive treatments, followed by multiple pharmacological and non-pharmacological options in prophylactic treatments. In conclusion, numerous effective and safe treatments are available in treating patients with episodic, chronic, and pharmacoresistant CH according to the clinical profile of each patient. |
| first_indexed | 2024-03-11T15:20:36Z |
| format | Article |
| id | doaj.art-e795346a3d49422f9dd780e2a6bec7dd |
| institution | Directory Open Access Journal |
| issn | 2673-561X |
| language | English |
| last_indexed | 2024-03-11T15:20:36Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pain Research |
| spelling | doaj.art-e795346a3d49422f9dd780e2a6bec7dd2023-10-28T21:23:42ZengFrontiers Media S.A.Frontiers in Pain Research2673-561X2023-10-01410.3389/fpain.2023.12655401265540Cluster headache: state of the art in treatmentIldefonso Rodriguez-Leyva0Maria-Karina Velez-Jimenez1Silvia García2Juan Alberto Nader-Kawachi3Adriana Patricia Martínez-Mayorga4Agustín Melo-Carrillo5Humberto Juárez-Jimenez6Marco Martinez-Gurrola7Manuel Gudiño-Castelazo8Erwin Chiquete9Jorge Villareal-Careaga10Alejandro Marfil11Paul David Uribe-Jaimes12Rubén Dario Vargas-García13Miguel Angel Collado-Ortiz14Daniel San-Juan15Department of Neurology, Faculty of Medicine, Central Hospital “Dr. Ignacio Morones Prieto,”Universidad Autónoma de San Luis Potosi, San Luis Potosi, MexicoDepartment of Neurology, Hospital Angeles Lomas, Mexico City, MexicoClinical Research Department, Centro Médico Nacional “20 de Noviembre,” ISSSTE, Mexico City, MexicoNeurology and Neurosurgery Center, Médica Sur Hospital, Mexico City, MexicoDepartament of Neurophysiology, Universidad Autónoma de San Luis Potosí, San Luis Potosi, MexicoAnesthesia Department, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United StatesNeurology, Médica Sur Hospital, Mexico City, MexicoDepartment of Neurology, General Hospital 450 Durango, Mexico City, MexicoStar Medica Group, Star Medica Hospital Lomas Verdes, Mexico City, Mexico0Department of Neurology and Psychiatry, National Institute of Medical Science and Nutrition “Salvador Zubirán,”Mexico City, Mexico1Department of Neurology, General Hospital of Culiacan, Culiacan, Mexico2Headache and Chronic Pain Clinic, Neurology Service, Hospital Universitario “Dr. J. E. González” of the Universidad Autónoma de Nuevo Leon, Monterrey, Mexico3Neurological Center, ABC Medical Center, Mexico City, Mexico4Department of Neurology and Psychiatry, Clínica de Merida, Merida, Mexico City, Mexico3Neurological Center, ABC Medical Center, Mexico City, Mexico5Epilepsy Clinic of the National Institute of Neurology and Neurosurgery Manuel Velazco Suarez, Mexico City, MexicoCluster headache (CH) is the most common and devastating autonomic headache with multiple and recent advances in treatment. However, it usually goes unrecognized and is found to have a delayed and inappropriate treatment. This paper aims to review the current therapeutic options for patients with CH. We conducted a narrative literature review on the treatments available for this condition using the American Academy of Neurology (AAN) classification of therapeutic evidence. We found effective and safe pharmacological and non-pharmacological therapies with heterogeneity of clinical trial designs for patients with CH, and they are divided into three phases, namely, transitional, acute, and preventive interventions. Prednisone (A) is the most studied treatment in the transitional phase; acute attacks are treated using triptans (A), oxygen (A), and non-invasive transcutaneous vagal nerve stimulation (A). Verapamil (A) and monoclonal antibodies (possible A) are considered the first options in preventive treatments, followed by multiple pharmacological and non-pharmacological options in prophylactic treatments. In conclusion, numerous effective and safe treatments are available in treating patients with episodic, chronic, and pharmacoresistant CH according to the clinical profile of each patient.https://www.frontiersin.org/articles/10.3389/fpain.2023.1265540/fullcluster headachetreatmentclinical trialsdrugsneuromodulation |
| spellingShingle | Ildefonso Rodriguez-Leyva Maria-Karina Velez-Jimenez Silvia García Juan Alberto Nader-Kawachi Adriana Patricia Martínez-Mayorga Agustín Melo-Carrillo Humberto Juárez-Jimenez Marco Martinez-Gurrola Manuel Gudiño-Castelazo Erwin Chiquete Jorge Villareal-Careaga Alejandro Marfil Paul David Uribe-Jaimes Rubén Dario Vargas-García Miguel Angel Collado-Ortiz Daniel San-Juan Cluster headache: state of the art in treatment Frontiers in Pain Research cluster headache treatment clinical trials drugs neuromodulation |
| title | Cluster headache: state of the art in treatment |
| title_full | Cluster headache: state of the art in treatment |
| title_fullStr | Cluster headache: state of the art in treatment |
| title_full_unstemmed | Cluster headache: state of the art in treatment |
| title_short | Cluster headache: state of the art in treatment |
| title_sort | cluster headache state of the art in treatment |
| topic | cluster headache treatment clinical trials drugs neuromodulation |
| url | https://www.frontiersin.org/articles/10.3389/fpain.2023.1265540/full |
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