Animal Models of Temporomandibular Joint Osteoarthritis: Classification and Selection
Temporomandibular joint osteoarthritis (TMJOA) is a common degenerative joint disease that can cause severe pain and dysfunction. It has a serious impact on the quality of lives of patients. Since mechanism underlying the pathogenesis of TMJOA is not fully understood, the development of effective to...
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| Format: | Article |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.859517/full |
| _version_ | 1811303960848367616 |
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| author | Yuqing Zhao Yuqing Zhao Yanxin An Libo Zhou Fan Wu Gaoyi Wu Jing Wang Jing Wang Lei Chen |
| author_facet | Yuqing Zhao Yuqing Zhao Yanxin An Libo Zhou Fan Wu Gaoyi Wu Jing Wang Jing Wang Lei Chen |
| author_sort | Yuqing Zhao |
| collection | DOAJ |
| description | Temporomandibular joint osteoarthritis (TMJOA) is a common degenerative joint disease that can cause severe pain and dysfunction. It has a serious impact on the quality of lives of patients. Since mechanism underlying the pathogenesis of TMJOA is not fully understood, the development of effective tools for early diagnosis and disease-modifying therapies has been hindered. Animal models play a key role in understanding the pathological process of diseases and evaluating new therapeutic interventions. Although some similarities in disease processes between animals and humans are known, no one animal model is sufficient for studying all characteristics of TMJOA, as each model has different translatability to human clinical conditions. For the past 4 decades, TMJOA animal models have been studied by numerous researchers and can be broadly divided into induced, naturally occurring, and genetically modified models. The induced models can be divided into invasive models (intra-articular injection and surgical induction) or non-invasive models (mechanical loading, high-fat diet, and sleep deprivation). Different types of animal models simulate different pathological expressions of TMJOA and have their unique characteristics. Currently, mice, rats, and rabbits are commonly used in the study of TMJOA. This review sought to provide a general description of current experimental models of TMJOA and assist researchers in selecting the most appropriate models for different kinds of research. |
| first_indexed | 2024-04-13T07:57:27Z |
| format | Article |
| id | doaj.art-e79547c4bd8f484fa02e7da1e5ffca54 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-13T07:57:27Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-e79547c4bd8f484fa02e7da1e5ffca542022-12-22T02:55:22ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-04-011310.3389/fphys.2022.859517859517Animal Models of Temporomandibular Joint Osteoarthritis: Classification and SelectionYuqing Zhao0Yuqing Zhao1Yanxin An2Libo Zhou3Fan Wu4Gaoyi Wu5Jing Wang6Jing Wang7Lei Chen8Department of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, ChinaSchool of Stomatology, Heilongjiang Key Lab of Oral Biomedicine Materials and Clinical Application & Experimental Center for Stomatology Engineering, Jiamusi University, Jiamusi, ChinaDepartment of General Surgery, The First Affiliated Hospital of Xi’an Medical University, Xi’an, ChinaSchool of Basic Medicine, Heilongjiang Key Lab of Oral Biomedicine Materials and Clinical Application & Experimental Center for Stomatology Engineering, Jiamusi University, Jiamusi, ChinaSchool of Stomatology, Heilongjiang Key Lab of Oral Biomedicine Materials and Clinical Application & Experimental Center for Stomatology Engineering, Jiamusi University, Jiamusi, ChinaSchool of Stomatology, Heilongjiang Key Lab of Oral Biomedicine Materials and Clinical Application & Experimental Center for Stomatology Engineering, Jiamusi University, Jiamusi, ChinaDepartment of Oral Implants, School of Stomatology, National Clinical Research Center for Oral Diseases & State Key Laboratory of Military Stomatology & Shaanxi Key Laboratory of Stomatology, The Fourth Military Medical University, Xi’an, ChinaKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an, ChinaDepartment of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, ChinaTemporomandibular joint osteoarthritis (TMJOA) is a common degenerative joint disease that can cause severe pain and dysfunction. It has a serious impact on the quality of lives of patients. Since mechanism underlying the pathogenesis of TMJOA is not fully understood, the development of effective tools for early diagnosis and disease-modifying therapies has been hindered. Animal models play a key role in understanding the pathological process of diseases and evaluating new therapeutic interventions. Although some similarities in disease processes between animals and humans are known, no one animal model is sufficient for studying all characteristics of TMJOA, as each model has different translatability to human clinical conditions. For the past 4 decades, TMJOA animal models have been studied by numerous researchers and can be broadly divided into induced, naturally occurring, and genetically modified models. The induced models can be divided into invasive models (intra-articular injection and surgical induction) or non-invasive models (mechanical loading, high-fat diet, and sleep deprivation). Different types of animal models simulate different pathological expressions of TMJOA and have their unique characteristics. Currently, mice, rats, and rabbits are commonly used in the study of TMJOA. This review sought to provide a general description of current experimental models of TMJOA and assist researchers in selecting the most appropriate models for different kinds of research.https://www.frontiersin.org/articles/10.3389/fphys.2022.859517/fulltemporomandibular jointosteoarthritisanimal modelsinduced modelsnaturally occurring modelsgenetically modified models |
| spellingShingle | Yuqing Zhao Yuqing Zhao Yanxin An Libo Zhou Fan Wu Gaoyi Wu Jing Wang Jing Wang Lei Chen Animal Models of Temporomandibular Joint Osteoarthritis: Classification and Selection Frontiers in Physiology temporomandibular joint osteoarthritis animal models induced models naturally occurring models genetically modified models |
| title | Animal Models of Temporomandibular Joint Osteoarthritis: Classification and Selection |
| title_full | Animal Models of Temporomandibular Joint Osteoarthritis: Classification and Selection |
| title_fullStr | Animal Models of Temporomandibular Joint Osteoarthritis: Classification and Selection |
| title_full_unstemmed | Animal Models of Temporomandibular Joint Osteoarthritis: Classification and Selection |
| title_short | Animal Models of Temporomandibular Joint Osteoarthritis: Classification and Selection |
| title_sort | animal models of temporomandibular joint osteoarthritis classification and selection |
| topic | temporomandibular joint osteoarthritis animal models induced models naturally occurring models genetically modified models |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.859517/full |
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