The MAOA and COMT Gene Polymorphisms in Patients with Schizophrenia Committed Homicide
Numerous studies have indicated that aggression and homicide are more frequent among people with schizophrenia than in the general population. There is considerable evidence that schizophrenia involves a dysbalance between subcortical and cortical dopaminergic systems. The major pathways for catecho...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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International Medical Research and Development Corporation
2014-12-01
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| Series: | International Journal of Biomedicine |
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| Online Access: | http://ijbm.org/articles/Article4(4)_CR3.pdf |
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| author | V.A. Soldatkin T.P. Shkurat A.S. Bobkov E.V. Mashkina A.V. Tretyakov A.Ya. Perekhov V.V. Mrykhin A.I. Kovalev O.A. Bukhanovskaya M.N. Kryuchkova |
| author_facet | V.A. Soldatkin T.P. Shkurat A.S. Bobkov E.V. Mashkina A.V. Tretyakov A.Ya. Perekhov V.V. Mrykhin A.I. Kovalev O.A. Bukhanovskaya M.N. Kryuchkova |
| author_sort | V.A. Soldatkin |
| collection | DOAJ |
| description | Numerous studies have indicated that aggression and homicide are more frequent among people with schizophrenia than in the general population. There is considerable evidence that schizophrenia involves a dysbalance between subcortical and cortical dopaminergic systems. The major pathways for catecholamine degradation are oxidative deamination through the action of monoamine oxidase A (MAOA) and by methylation through the action of catechol-O-methyltransferase (COMT). Activity of both enzymes is encoded by the corresponding genes—MAOA and COMT. The aim of our study was to analyze the association between the COMT-Val158Met and MAOA-uVNTR polymorphisms and the risk of committing homicide by patients with schizophrenia.
Methods: The study included 50 Caucasian male patients with paranoid schizophrenia (PS). All patients were divided into two groups: Group 1 consisted of 26 PS patients who have committed homicide; Group 2 consisted of 24 PS patients who did not have a history of socially violent behavior. The control group comprised 23 apparently healthy Caucasian men of the same age. All patients underwent clinical-psychopathological and clinical-anamnestic examinations. Molecular genetic studies were performed in the Shared Research Facility Center "High Technologies" at SFedU.
Results: Our study revealed no direct correlation between the COMT-Val158Met and MAOA-uVNTR polymorphisms and risk of committing homicide by patients with schizophrenia. At the same time, we detected an association between high-activity gene variants, viz., the MAOA-4R allele and the COMT-158Met/158Met genotype, and the schizoid and unstable premorbid accentuation in patients who had committed murder, whereas the schizoid and unstable accentuation correlated with homicide behavior in patients with schizophrenia.
Conclusion: The obtained findings suggest that genetic variation affects the homicidal behavior indirectly, through the various types of premorbid accentuation and confirm the validity of the well-known concept of "syndrome-person-situation," traced back to the mid-20th century, which explains the commission of serious offenses by patients with schizophrenia. |
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| id | doaj.art-e798fab8d4714ac0b70c063a46a926d1 |
| institution | Directory Open Access Journal |
| issn | 2158-0510 2158-0529 |
| language | English |
| last_indexed | 2024-12-22T22:28:41Z |
| publishDate | 2014-12-01 |
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| series | International Journal of Biomedicine |
| spelling | doaj.art-e798fab8d4714ac0b70c063a46a926d12022-12-21T18:10:30ZengInternational Medical Research and Development CorporationInternational Journal of Biomedicine2158-05102158-05292014-12-0144213217The MAOA and COMT Gene Polymorphisms in Patients with Schizophrenia Committed HomicideV.A. Soldatkin0T.P. Shkurat1A.S. Bobkov2E.V. Mashkina3A.V. Tretyakov4A.Ya. Perekhov5V.V. Mrykhin6A.I. Kovalev7O.A. Bukhanovskaya8M.N. Kryuchkova9Rostov State Medical University, Rostov-on-Don, RussiaSouthern Federal University, Rostov-on-Don, RussiaRostov State Medical University, Rostov-on-Don, RussiaSouthern Federal University, Rostov-on-Don, RussiaPsychoneurological dispensary, Novocherkassk, RussiaRostov State Medical University, Rostov-on-Don, RussiaRostov State Medical University, Rostov-on-Don, RussiaRostov State Medical University, Rostov-on-Don, RussiaRostov State Medical University, Rostov-on-Don, RussiaRostov State Medical University, Rostov-on-Don, RussiaNumerous studies have indicated that aggression and homicide are more frequent among people with schizophrenia than in the general population. There is considerable evidence that schizophrenia involves a dysbalance between subcortical and cortical dopaminergic systems. The major pathways for catecholamine degradation are oxidative deamination through the action of monoamine oxidase A (MAOA) and by methylation through the action of catechol-O-methyltransferase (COMT). Activity of both enzymes is encoded by the corresponding genes—MAOA and COMT. The aim of our study was to analyze the association between the COMT-Val158Met and MAOA-uVNTR polymorphisms and the risk of committing homicide by patients with schizophrenia. Methods: The study included 50 Caucasian male patients with paranoid schizophrenia (PS). All patients were divided into two groups: Group 1 consisted of 26 PS patients who have committed homicide; Group 2 consisted of 24 PS patients who did not have a history of socially violent behavior. The control group comprised 23 apparently healthy Caucasian men of the same age. All patients underwent clinical-psychopathological and clinical-anamnestic examinations. Molecular genetic studies were performed in the Shared Research Facility Center "High Technologies" at SFedU. Results: Our study revealed no direct correlation between the COMT-Val158Met and MAOA-uVNTR polymorphisms and risk of committing homicide by patients with schizophrenia. At the same time, we detected an association between high-activity gene variants, viz., the MAOA-4R allele and the COMT-158Met/158Met genotype, and the schizoid and unstable premorbid accentuation in patients who had committed murder, whereas the schizoid and unstable accentuation correlated with homicide behavior in patients with schizophrenia. Conclusion: The obtained findings suggest that genetic variation affects the homicidal behavior indirectly, through the various types of premorbid accentuation and confirm the validity of the well-known concept of "syndrome-person-situation," traced back to the mid-20th century, which explains the commission of serious offenses by patients with schizophrenia.http://ijbm.org/articles/Article4(4)_CR3.pdfschizophrenia;homicide;MAOA gene;COMT gene. |
| spellingShingle | V.A. Soldatkin T.P. Shkurat A.S. Bobkov E.V. Mashkina A.V. Tretyakov A.Ya. Perekhov V.V. Mrykhin A.I. Kovalev O.A. Bukhanovskaya M.N. Kryuchkova The MAOA and COMT Gene Polymorphisms in Patients with Schizophrenia Committed Homicide International Journal of Biomedicine schizophrenia; homicide; MAOA gene; COMT gene. |
| title | The MAOA and COMT Gene Polymorphisms in Patients with Schizophrenia Committed Homicide |
| title_full | The MAOA and COMT Gene Polymorphisms in Patients with Schizophrenia Committed Homicide |
| title_fullStr | The MAOA and COMT Gene Polymorphisms in Patients with Schizophrenia Committed Homicide |
| title_full_unstemmed | The MAOA and COMT Gene Polymorphisms in Patients with Schizophrenia Committed Homicide |
| title_short | The MAOA and COMT Gene Polymorphisms in Patients with Schizophrenia Committed Homicide |
| title_sort | maoa and comt gene polymorphisms in patients with schizophrenia committed homicide |
| topic | schizophrenia; homicide; MAOA gene; COMT gene. |
| url | http://ijbm.org/articles/Article4(4)_CR3.pdf |
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