VDACs: An Outlook on Biochemical Regulation and Function in Animal and Plant Systems
The voltage-dependent anion channels (VDACs) are the most abundant proteins present on the outer mitochondrial membrane. They serve a myriad of functions ranging from energy and metabolite exchange to highly debatable roles in apoptosis. Their role in molecular transport puts them on the center stag...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2021.683920/full |
| _version_ | 1819035487657000960 |
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| author | Barkha Ravi Poonam Kanwar Sibaji K. Sanyal Malathi Bheri Girdhar K. Pandey |
| author_facet | Barkha Ravi Poonam Kanwar Sibaji K. Sanyal Malathi Bheri Girdhar K. Pandey |
| author_sort | Barkha Ravi |
| collection | DOAJ |
| description | The voltage-dependent anion channels (VDACs) are the most abundant proteins present on the outer mitochondrial membrane. They serve a myriad of functions ranging from energy and metabolite exchange to highly debatable roles in apoptosis. Their role in molecular transport puts them on the center stage as communicators between cytoplasmic and mitochondrial signaling events. Beyond their general role as interchangeable pores, members of this family may exhibit specific functions. Even after nearly five decades of their discovery, their role in plant systems is still a new and rapidly emerging field. The information on biochemical regulation of VDACs is limited. Various interacting proteins and post-translational modifications (PTMs) modulate VDAC functions, amongst these, phosphorylation is quite noticeable. In this review, we have tried to give a glimpse of the recent advancements in the biochemical/interactional regulation of plant VDACs. We also cover a critical analysis on the importance of PTMs in the functional regulation of VDACs. Besides, the review also encompasses numerous studies which can identify VDACs as a connecting link between Ca2+ and reactive oxygen species signaling in special reference to the plant systems. |
| first_indexed | 2024-12-21T07:50:25Z |
| format | Article |
| id | doaj.art-e79969de4ea84acc8570a1f3226ca834 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-21T07:50:25Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-e79969de4ea84acc8570a1f3226ca8342022-12-21T19:11:05ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-08-011210.3389/fphys.2021.683920683920VDACs: An Outlook on Biochemical Regulation and Function in Animal and Plant SystemsBarkha RaviPoonam KanwarSibaji K. SanyalMalathi BheriGirdhar K. PandeyThe voltage-dependent anion channels (VDACs) are the most abundant proteins present on the outer mitochondrial membrane. They serve a myriad of functions ranging from energy and metabolite exchange to highly debatable roles in apoptosis. Their role in molecular transport puts them on the center stage as communicators between cytoplasmic and mitochondrial signaling events. Beyond their general role as interchangeable pores, members of this family may exhibit specific functions. Even after nearly five decades of their discovery, their role in plant systems is still a new and rapidly emerging field. The information on biochemical regulation of VDACs is limited. Various interacting proteins and post-translational modifications (PTMs) modulate VDAC functions, amongst these, phosphorylation is quite noticeable. In this review, we have tried to give a glimpse of the recent advancements in the biochemical/interactional regulation of plant VDACs. We also cover a critical analysis on the importance of PTMs in the functional regulation of VDACs. Besides, the review also encompasses numerous studies which can identify VDACs as a connecting link between Ca2+ and reactive oxygen species signaling in special reference to the plant systems.https://www.frontiersin.org/articles/10.3389/fphys.2021.683920/fullmitochondrial channelbiochemical regulationphosphorylationcell signalingCa2+reactive oxygen species |
| spellingShingle | Barkha Ravi Poonam Kanwar Sibaji K. Sanyal Malathi Bheri Girdhar K. Pandey VDACs: An Outlook on Biochemical Regulation and Function in Animal and Plant Systems Frontiers in Physiology mitochondrial channel biochemical regulation phosphorylation cell signaling Ca2+ reactive oxygen species |
| title | VDACs: An Outlook on Biochemical Regulation and Function in Animal and Plant Systems |
| title_full | VDACs: An Outlook on Biochemical Regulation and Function in Animal and Plant Systems |
| title_fullStr | VDACs: An Outlook on Biochemical Regulation and Function in Animal and Plant Systems |
| title_full_unstemmed | VDACs: An Outlook on Biochemical Regulation and Function in Animal and Plant Systems |
| title_short | VDACs: An Outlook on Biochemical Regulation and Function in Animal and Plant Systems |
| title_sort | vdacs an outlook on biochemical regulation and function in animal and plant systems |
| topic | mitochondrial channel biochemical regulation phosphorylation cell signaling Ca2+ reactive oxygen species |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2021.683920/full |
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