Stem Cell Therapy for Neonatal Hypoxic-Ischemic Encephalopathy: A Systematic Review of Preclinical Studies
Neonatal hypoxic-ischemic encephalopathy (HIE) is an important cause of mortality and morbidity in the perinatal period. This condition results from a period of ischemia and hypoxia to the brain of neonates, leading to several disorders that profoundly affect the daily life of patients and their fam...
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MDPI AG
2021-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/6/3142 |
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| author | Inês Serrenho Miguel Rosado Alexandra Dinis Carla M. Cardoso Mário Grãos Bruno Manadas Graça Baltazar |
| author_facet | Inês Serrenho Miguel Rosado Alexandra Dinis Carla M. Cardoso Mário Grãos Bruno Manadas Graça Baltazar |
| author_sort | Inês Serrenho |
| collection | DOAJ |
| description | Neonatal hypoxic-ischemic encephalopathy (HIE) is an important cause of mortality and morbidity in the perinatal period. This condition results from a period of ischemia and hypoxia to the brain of neonates, leading to several disorders that profoundly affect the daily life of patients and their families. Currently, therapeutic hypothermia (TH) is the standard of care in developing countries; however, TH is not always effective, especially in severe cases of HIE. Addressing this concern, several preclinical studies assessed the potential of stem cell therapy (SCT) for HIE. With this systematic review, we gathered information included in 58 preclinical studies from the last decade, focusing on the ones using stem cells isolated from the umbilical cord blood, umbilical cord tissue, placenta, and bone marrow. Outstandingly, about 80% of these studies reported a significant improvement of cognitive and/or sensorimotor function, as well as decreased brain damage. These results show the potential of SCT for HIE and the possibility of this therapy, in combination with TH, becoming the next therapeutic approach for HIE. Nonetheless, few preclinical studies assessed the combination of TH and SCT for HIE, and the existent studies show some contradictory results, revealing the need to further explore this line of research. |
| first_indexed | 2024-03-10T13:06:16Z |
| format | Article |
| id | doaj.art-e799d13b6bc942868314b3475c358a4d |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T13:06:16Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e799d13b6bc942868314b3475c358a4d2023-11-21T11:10:15ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-03-01226314210.3390/ijms22063142Stem Cell Therapy for Neonatal Hypoxic-Ischemic Encephalopathy: A Systematic Review of Preclinical StudiesInês Serrenho0Miguel Rosado1Alexandra Dinis2Carla M. Cardoso3Mário Grãos4Bruno Manadas5Graça Baltazar6Centro de Investigação em Ciências da Saúde (CICS-UBI), Universidade da Beira Interior, 6200-506 Covilhã, PortugalCNC—Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, PortugalPediatric Intensive Care Unit, Hospital Pediátrico, Centro Hospitalar e Universitário de Coimbra, 3000-075 Coimbra, PortugalCrioestaminal, 3060-197 Cantanhede, PortugalCNC—Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, PortugalCNC—Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, PortugalCentro de Investigação em Ciências da Saúde (CICS-UBI), Universidade da Beira Interior, 6200-506 Covilhã, PortugalNeonatal hypoxic-ischemic encephalopathy (HIE) is an important cause of mortality and morbidity in the perinatal period. This condition results from a period of ischemia and hypoxia to the brain of neonates, leading to several disorders that profoundly affect the daily life of patients and their families. Currently, therapeutic hypothermia (TH) is the standard of care in developing countries; however, TH is not always effective, especially in severe cases of HIE. Addressing this concern, several preclinical studies assessed the potential of stem cell therapy (SCT) for HIE. With this systematic review, we gathered information included in 58 preclinical studies from the last decade, focusing on the ones using stem cells isolated from the umbilical cord blood, umbilical cord tissue, placenta, and bone marrow. Outstandingly, about 80% of these studies reported a significant improvement of cognitive and/or sensorimotor function, as well as decreased brain damage. These results show the potential of SCT for HIE and the possibility of this therapy, in combination with TH, becoming the next therapeutic approach for HIE. Nonetheless, few preclinical studies assessed the combination of TH and SCT for HIE, and the existent studies show some contradictory results, revealing the need to further explore this line of research.https://www.mdpi.com/1422-0067/22/6/3142hypoxic-ischemic encephalopathystem cell therapyumbilical cord blood cellsumbilical cord tissuemesenchymal stem/stromal cellstherapeutic hypothermia |
| spellingShingle | Inês Serrenho Miguel Rosado Alexandra Dinis Carla M. Cardoso Mário Grãos Bruno Manadas Graça Baltazar Stem Cell Therapy for Neonatal Hypoxic-Ischemic Encephalopathy: A Systematic Review of Preclinical Studies International Journal of Molecular Sciences hypoxic-ischemic encephalopathy stem cell therapy umbilical cord blood cells umbilical cord tissue mesenchymal stem/stromal cells therapeutic hypothermia |
| title | Stem Cell Therapy for Neonatal Hypoxic-Ischemic Encephalopathy: A Systematic Review of Preclinical Studies |
| title_full | Stem Cell Therapy for Neonatal Hypoxic-Ischemic Encephalopathy: A Systematic Review of Preclinical Studies |
| title_fullStr | Stem Cell Therapy for Neonatal Hypoxic-Ischemic Encephalopathy: A Systematic Review of Preclinical Studies |
| title_full_unstemmed | Stem Cell Therapy for Neonatal Hypoxic-Ischemic Encephalopathy: A Systematic Review of Preclinical Studies |
| title_short | Stem Cell Therapy for Neonatal Hypoxic-Ischemic Encephalopathy: A Systematic Review of Preclinical Studies |
| title_sort | stem cell therapy for neonatal hypoxic ischemic encephalopathy a systematic review of preclinical studies |
| topic | hypoxic-ischemic encephalopathy stem cell therapy umbilical cord blood cells umbilical cord tissue mesenchymal stem/stromal cells therapeutic hypothermia |
| url | https://www.mdpi.com/1422-0067/22/6/3142 |
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