A tunable dual-input system for on-demand dynamic gene expression regulation
Cellular systems have numerous mechanisms to control gene expression. Here the authors build a Tet-On system with conditional destablising elements to regulate gene expression and protein stability, allowing fine modulation of mESC signalling pathways.
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-12329-9 |
| _version_ | 1830287978360995840 |
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| author | Elisa Pedone Lorena Postiglione Francesco Aulicino Dan L. Rocca Sandra Montes-Olivas Mahmoud Khazim Diego di Bernardo Maria Pia Cosma Lucia Marucci |
| author_facet | Elisa Pedone Lorena Postiglione Francesco Aulicino Dan L. Rocca Sandra Montes-Olivas Mahmoud Khazim Diego di Bernardo Maria Pia Cosma Lucia Marucci |
| author_sort | Elisa Pedone |
| collection | DOAJ |
| description | Cellular systems have numerous mechanisms to control gene expression. Here the authors build a Tet-On system with conditional destablising elements to regulate gene expression and protein stability, allowing fine modulation of mESC signalling pathways. |
| first_indexed | 2024-12-19T04:27:35Z |
| format | Article |
| id | doaj.art-e79a3cc6f3294f59896d1257115ecf15 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T04:27:35Z |
| publishDate | 2019-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e79a3cc6f3294f59896d1257115ecf152022-12-21T20:36:00ZengNature PortfolioNature Communications2041-17232019-10-0110111310.1038/s41467-019-12329-9A tunable dual-input system for on-demand dynamic gene expression regulationElisa Pedone0Lorena Postiglione1Francesco Aulicino2Dan L. Rocca3Sandra Montes-Olivas4Mahmoud Khazim5Diego di Bernardo6Maria Pia Cosma7Lucia Marucci8Department of Engineering Mathematics, University of BristolDepartment of Engineering Mathematics, University of BristolBrisSynBioDepartment of Engineering Mathematics, University of BristolDepartment of Engineering Mathematics, University of BristolDepartment of Engineering Mathematics, University of BristolTelethon Institute of Genetics and Medicine Via Campi Flegrei 34Centre for Genomic Regulation (CRG)Department of Engineering Mathematics, University of BristolCellular systems have numerous mechanisms to control gene expression. Here the authors build a Tet-On system with conditional destablising elements to regulate gene expression and protein stability, allowing fine modulation of mESC signalling pathways.https://doi.org/10.1038/s41467-019-12329-9 |
| spellingShingle | Elisa Pedone Lorena Postiglione Francesco Aulicino Dan L. Rocca Sandra Montes-Olivas Mahmoud Khazim Diego di Bernardo Maria Pia Cosma Lucia Marucci A tunable dual-input system for on-demand dynamic gene expression regulation Nature Communications |
| title | A tunable dual-input system for on-demand dynamic gene expression regulation |
| title_full | A tunable dual-input system for on-demand dynamic gene expression regulation |
| title_fullStr | A tunable dual-input system for on-demand dynamic gene expression regulation |
| title_full_unstemmed | A tunable dual-input system for on-demand dynamic gene expression regulation |
| title_short | A tunable dual-input system for on-demand dynamic gene expression regulation |
| title_sort | tunable dual input system for on demand dynamic gene expression regulation |
| url | https://doi.org/10.1038/s41467-019-12329-9 |
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