Association between Interleukin-23 Receptor R381Q Gene Polymorphism and Asthma
The SNP (rs11209026, Arg381Gln, R381Q) in the IL-23 receptor (IL23R) confers protection against multiple inflammatory diseases, representing one of the most significant human genetic polymorphisms in inflammatory diseases. We, therefore, investigated the association between IL-23 R R381Q gene polymo...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2015-10-01
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| Series: | Iranian Journal of Allergy, Asthma and Immunology |
| Subjects: | |
| Online Access: | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/585 |
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| author | Ali Mosayebian Mazdak Ganjalikhani-Hakemi Rezvan Meshkat Ramin Ghasemi Hossain Khan-Ahmad Morteza Samadi |
| author_facet | Ali Mosayebian Mazdak Ganjalikhani-Hakemi Rezvan Meshkat Ramin Ghasemi Hossain Khan-Ahmad Morteza Samadi |
| author_sort | Ali Mosayebian |
| collection | DOAJ |
| description | The SNP (rs11209026, Arg381Gln, R381Q) in the IL-23 receptor (IL23R) confers protection against multiple inflammatory diseases, representing one of the most significant human genetic polymorphisms in inflammatory diseases. We, therefore, investigated the association between IL-23 R R381Q gene polymorphism and asthma.This case-control study was performed on 209 patients, and 200 healthy controls. Using PCR-RFLP, the R381Q variant was screened in the IL-23R gene of the patients and controls.Serum IgE levels were measured using ELISA technique. Eosinophil absolute count was done with Sesmex cell counter.Our results indicated that the genotype and allele frequencies of the IL-23R R381Q polymorphism is significantly different between asthmatic patients and control subjects (p<0.001; odd ratio= 0.266; 95%, CI=0.118-0.604. Moreover, the asthmatic patients had higher eosinophil count and total serum IgE levels than controls as expected (p<0.001).The present study suggested that R381Q polymorphism in IL-23 receptor may be a predisposing allele for asthma. |
| first_indexed | 2024-04-13T00:21:47Z |
| format | Article |
| id | doaj.art-e79b6fc3f2e14b93948ef492f8dec229 |
| institution | Directory Open Access Journal |
| issn | 1735-1502 1735-5249 |
| language | English |
| last_indexed | 2024-04-13T00:21:47Z |
| publishDate | 2015-10-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Allergy, Asthma and Immunology |
| spelling | doaj.art-e79b6fc3f2e14b93948ef492f8dec2292022-12-22T03:10:46ZengTehran University of Medical SciencesIranian Journal of Allergy, Asthma and Immunology1735-15021735-52492015-10-01144547Association between Interleukin-23 Receptor R381Q Gene Polymorphism and AsthmaAli Mosayebian0Mazdak Ganjalikhani-Hakemi1Rezvan Meshkat2Ramin Ghasemi3Hossain Khan-Ahmad4Morteza Samadi5Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.Cellular and Molecular Immunology Research Center, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.Department of Immunology, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.Department of Genetics and Molecular Biology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.Department of Immunology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran AND Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.The SNP (rs11209026, Arg381Gln, R381Q) in the IL-23 receptor (IL23R) confers protection against multiple inflammatory diseases, representing one of the most significant human genetic polymorphisms in inflammatory diseases. We, therefore, investigated the association between IL-23 R R381Q gene polymorphism and asthma.This case-control study was performed on 209 patients, and 200 healthy controls. Using PCR-RFLP, the R381Q variant was screened in the IL-23R gene of the patients and controls.Serum IgE levels were measured using ELISA technique. Eosinophil absolute count was done with Sesmex cell counter.Our results indicated that the genotype and allele frequencies of the IL-23R R381Q polymorphism is significantly different between asthmatic patients and control subjects (p<0.001; odd ratio= 0.266; 95%, CI=0.118-0.604. Moreover, the asthmatic patients had higher eosinophil count and total serum IgE levels than controls as expected (p<0.001).The present study suggested that R381Q polymorphism in IL-23 receptor may be a predisposing allele for asthma.https://ijaai.tums.ac.ir/index.php/ijaai/article/view/585AsthmaIL-23 ReceptorSingle Nucleotide Polymorphism |
| spellingShingle | Ali Mosayebian Mazdak Ganjalikhani-Hakemi Rezvan Meshkat Ramin Ghasemi Hossain Khan-Ahmad Morteza Samadi Association between Interleukin-23 Receptor R381Q Gene Polymorphism and Asthma Iranian Journal of Allergy, Asthma and Immunology Asthma IL-23 Receptor Single Nucleotide Polymorphism |
| title | Association between Interleukin-23 Receptor R381Q Gene Polymorphism and Asthma |
| title_full | Association between Interleukin-23 Receptor R381Q Gene Polymorphism and Asthma |
| title_fullStr | Association between Interleukin-23 Receptor R381Q Gene Polymorphism and Asthma |
| title_full_unstemmed | Association between Interleukin-23 Receptor R381Q Gene Polymorphism and Asthma |
| title_short | Association between Interleukin-23 Receptor R381Q Gene Polymorphism and Asthma |
| title_sort | association between interleukin 23 receptor r381q gene polymorphism and asthma |
| topic | Asthma IL-23 Receptor Single Nucleotide Polymorphism |
| url | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/585 |
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