Intercellular Protein Transfer from Thymocytes to Thymic Epithelial Cells.
Promiscuous expression of tissue restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs) is crucial for negative selection of self-reactive T cells to establish central tolerance. Intercellular transfer of self-peptide-MHC complexes from mTECs to thymic dendritic cells (DCs) allows D...
| Principais autores: | , , |
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| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
Public Library of Science (PLoS)
2016-01-01
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| coleção: | PLoS ONE |
| Acesso em linha: | http://europepmc.org/articles/PMC4811443?pdf=render |
| _version_ | 1828264110662352896 |
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| author | Hong-Xia Wang Yu-Rong Qiu Xiao-Ping Zhong |
| author_facet | Hong-Xia Wang Yu-Rong Qiu Xiao-Ping Zhong |
| author_sort | Hong-Xia Wang |
| collection | DOAJ |
| description | Promiscuous expression of tissue restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs) is crucial for negative selection of self-reactive T cells to establish central tolerance. Intercellular transfer of self-peptide-MHC complexes from mTECs to thymic dendritic cells (DCs) allows DCs to acquire TRAs, which in turn contributes to negative selection and regulatory T cell generation. However, mTECs are unlikely to express all TRAs, such as immunoglobulins generated only in B cells after somatic recombination, hyper-mutation, or class-switches. We report here that both mTECs and cortical TECs can efficiently acquire not only cell surface but also intracellular proteins from thymocytes. This reveals a previously unappreciated intercellular sharing of molecules from thymocytes to TECs, which may broaden the TRA inventory in mTECs for establishing a full spectrum of central tolerance. |
| first_indexed | 2024-04-13T04:19:54Z |
| format | Article |
| id | doaj.art-e79bb7dfc8614ffab1bcb29b51bb33c7 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T04:19:54Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-e79bb7dfc8614ffab1bcb29b51bb33c72022-12-22T03:02:49ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01113e015264110.1371/journal.pone.0152641Intercellular Protein Transfer from Thymocytes to Thymic Epithelial Cells.Hong-Xia WangYu-Rong QiuXiao-Ping ZhongPromiscuous expression of tissue restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs) is crucial for negative selection of self-reactive T cells to establish central tolerance. Intercellular transfer of self-peptide-MHC complexes from mTECs to thymic dendritic cells (DCs) allows DCs to acquire TRAs, which in turn contributes to negative selection and regulatory T cell generation. However, mTECs are unlikely to express all TRAs, such as immunoglobulins generated only in B cells after somatic recombination, hyper-mutation, or class-switches. We report here that both mTECs and cortical TECs can efficiently acquire not only cell surface but also intracellular proteins from thymocytes. This reveals a previously unappreciated intercellular sharing of molecules from thymocytes to TECs, which may broaden the TRA inventory in mTECs for establishing a full spectrum of central tolerance.http://europepmc.org/articles/PMC4811443?pdf=render |
| spellingShingle | Hong-Xia Wang Yu-Rong Qiu Xiao-Ping Zhong Intercellular Protein Transfer from Thymocytes to Thymic Epithelial Cells. PLoS ONE |
| title | Intercellular Protein Transfer from Thymocytes to Thymic Epithelial Cells. |
| title_full | Intercellular Protein Transfer from Thymocytes to Thymic Epithelial Cells. |
| title_fullStr | Intercellular Protein Transfer from Thymocytes to Thymic Epithelial Cells. |
| title_full_unstemmed | Intercellular Protein Transfer from Thymocytes to Thymic Epithelial Cells. |
| title_short | Intercellular Protein Transfer from Thymocytes to Thymic Epithelial Cells. |
| title_sort | intercellular protein transfer from thymocytes to thymic epithelial cells |
| url | http://europepmc.org/articles/PMC4811443?pdf=render |
| work_keys_str_mv | AT hongxiawang intercellularproteintransferfromthymocytestothymicepithelialcells AT yurongqiu intercellularproteintransferfromthymocytestothymicepithelialcells AT xiaopingzhong intercellularproteintransferfromthymocytestothymicepithelialcells |