Recent Advances in Polycaprolactones for Anticancer Drug Delivery
Poly(ε-Caprolactone)s are biodegradable and biocompatible polyesters that have gained considerable attention for drug delivery applications due to their slow degradation and ease of functionalization. One of the significant advantages of polycaprolactone is its ability to attach various functionalit...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/7/1977 |
| _version_ | 1797587827886653440 |
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| author | Abhi Bhadran Tejas Shah Godwin K. Babanyinah Himanshu Polara Somayeh Taslimy Michael C. Biewer Mihaela C. Stefan |
| author_facet | Abhi Bhadran Tejas Shah Godwin K. Babanyinah Himanshu Polara Somayeh Taslimy Michael C. Biewer Mihaela C. Stefan |
| author_sort | Abhi Bhadran |
| collection | DOAJ |
| description | Poly(ε-Caprolactone)s are biodegradable and biocompatible polyesters that have gained considerable attention for drug delivery applications due to their slow degradation and ease of functionalization. One of the significant advantages of polycaprolactone is its ability to attach various functionalities to its backbone, which is commonly accomplished through ring-opening polymerization (ROP) of functionalized caprolactone monomer. In this review, we aim to summarize some of the most recent advances in polycaprolactones and their potential application in drug delivery. We will discuss different types of polycaprolactone-based drug delivery systems and their behavior in response to different stimuli, their ability to target specific locations, morphology, as well as their drug loading and release capabilities. |
| first_indexed | 2024-03-11T00:44:23Z |
| format | Article |
| id | doaj.art-e79e9c753a0a41348a3704b85ea76ebe |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-11T00:44:23Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-e79e9c753a0a41348a3704b85ea76ebe2023-11-18T20:56:28ZengMDPI AGPharmaceutics1999-49232023-07-01157197710.3390/pharmaceutics15071977Recent Advances in Polycaprolactones for Anticancer Drug DeliveryAbhi Bhadran0Tejas Shah1Godwin K. Babanyinah2Himanshu Polara3Somayeh Taslimy4Michael C. Biewer5Mihaela C. Stefan6Department of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX 75080, USADepartment of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX 75080, USADepartment of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX 75080, USADepartment of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX 75080, USADepartment of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX 75080, USADepartment of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX 75080, USADepartment of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX 75080, USAPoly(ε-Caprolactone)s are biodegradable and biocompatible polyesters that have gained considerable attention for drug delivery applications due to their slow degradation and ease of functionalization. One of the significant advantages of polycaprolactone is its ability to attach various functionalities to its backbone, which is commonly accomplished through ring-opening polymerization (ROP) of functionalized caprolactone monomer. In this review, we aim to summarize some of the most recent advances in polycaprolactones and their potential application in drug delivery. We will discuss different types of polycaprolactone-based drug delivery systems and their behavior in response to different stimuli, their ability to target specific locations, morphology, as well as their drug loading and release capabilities.https://www.mdpi.com/1999-4923/15/7/1977polycaprolactonesring opening polymerizationcatalystfunctional caprolactone monomersdrug delivery systemspolymeric micelles |
| spellingShingle | Abhi Bhadran Tejas Shah Godwin K. Babanyinah Himanshu Polara Somayeh Taslimy Michael C. Biewer Mihaela C. Stefan Recent Advances in Polycaprolactones for Anticancer Drug Delivery Pharmaceutics polycaprolactones ring opening polymerization catalyst functional caprolactone monomers drug delivery systems polymeric micelles |
| title | Recent Advances in Polycaprolactones for Anticancer Drug Delivery |
| title_full | Recent Advances in Polycaprolactones for Anticancer Drug Delivery |
| title_fullStr | Recent Advances in Polycaprolactones for Anticancer Drug Delivery |
| title_full_unstemmed | Recent Advances in Polycaprolactones for Anticancer Drug Delivery |
| title_short | Recent Advances in Polycaprolactones for Anticancer Drug Delivery |
| title_sort | recent advances in polycaprolactones for anticancer drug delivery |
| topic | polycaprolactones ring opening polymerization catalyst functional caprolactone monomers drug delivery systems polymeric micelles |
| url | https://www.mdpi.com/1999-4923/15/7/1977 |
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