Survival Outcomes of Patients With Breast Cancer in a Mexican Population
PURPOSEThe Instituto Mexicano del Seguro Social is a tripartite contribution providing care to more than 74 million beneficiaries, representing more than 50% of the country's general population. This study aims to describe the survival outcomes and clinicopathologic characteristics of patients...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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American Society of Clinical Oncology
2024-02-01
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| Series: | JCO Global Oncology |
| Online Access: | https://ascopubs.org/doi/10.1200/GO.23.00233 |
| _version_ | 1797319721208512512 |
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| author | Rocio Grajales-Alvarez Alicia Gutiérrez-Mata Christian Pichardo-Piña Marcos Gutiérrez-De la Barrera Karim Dip-Borunda |
| author_facet | Rocio Grajales-Alvarez Alicia Gutiérrez-Mata Christian Pichardo-Piña Marcos Gutiérrez-De la Barrera Karim Dip-Borunda |
| author_sort | Rocio Grajales-Alvarez |
| collection | DOAJ |
| description | PURPOSEThe Instituto Mexicano del Seguro Social is a tripartite contribution providing care to more than 74 million beneficiaries, representing more than 50% of the country's general population. This study aims to describe the survival outcomes and clinicopathologic characteristics of patients with breast cancer at our Center.METHODSA retrospective cohort of patients with breast cancer treated between January 2012 and December 2020 was conducted. Survival outcomes were assessed using the Kaplan-Meier method. Univariate and multivariate analyses were performed using a Cox proportional hazards model.RESULTSThere were 5,264 patients included with a median follow-up of 54.9 months. Forty-three percent (n = 2,274) were diagnosed in stage I-IIA, 43.1% (n = 2,269) in stage IIB-III, and 7% (n = 383) in stage IV. At 5 years, disease-free survival was 74.9% (95% CI, 73.5 to 76.3) and overall survival (OS) 90.4% (95% CI, 89.4 to 91.3). For stage IV, it was 22.7% (95% CI, 17.3 to 28.5). High histologic grade (hazard ratio, 1.51 [95% CI, 1.34 to 1.7]; P < .001) and lymphovascular invasion (LVI; hazard ratio, 1.85 [95% CI, 1.62 to 2.1]; P < .001) were associated with a higher risk of recurrence.CONCLUSIONHistologic grade and LVI should be considered in the decision to treat with adjuvant chemotherapy in sites where genomic signatures are not available. Our OS data are comparable with other Mexican series; however, it is lower in stage IV. Much remains to be done at the national level, mainly regarding access to additional therapies for each breast cancer subtype. This work contributes to the evaluation of areas for improvement in outcomes in our population. |
| first_indexed | 2024-03-08T04:11:02Z |
| format | Article |
| id | doaj.art-e79ec1454ea74e88b0051dd9ac17b315 |
| institution | Directory Open Access Journal |
| issn | 2687-8941 |
| language | English |
| last_indexed | 2024-03-08T04:11:02Z |
| publishDate | 2024-02-01 |
| publisher | American Society of Clinical Oncology |
| record_format | Article |
| series | JCO Global Oncology |
| spelling | doaj.art-e79ec1454ea74e88b0051dd9ac17b3152024-02-08T20:59:21ZengAmerican Society of Clinical OncologyJCO Global Oncology2687-89412024-02-011010.1200/GO.23.00233Survival Outcomes of Patients With Breast Cancer in a Mexican PopulationRocio Grajales-Alvarez0Alicia Gutiérrez-Mata1Christian Pichardo-Piña2Marcos Gutiérrez-De la Barrera3Karim Dip-Borunda4Hospital de Oncología, Instituto Mexicano del Seguro Social, Mexico City, MexicoUnidad Médica de Alta Especialidad No. 1, Instituto Mexicano del Seguro Social, León, Mexico City, MexicoAditum Consulting Group, Mexico City, MexicoHospital de Oncología, Instituto Mexicano del Seguro Social, Mexico City, MexicoHospital de Oncología, Instituto Mexicano del Seguro Social, Mexico City, MexicoPURPOSEThe Instituto Mexicano del Seguro Social is a tripartite contribution providing care to more than 74 million beneficiaries, representing more than 50% of the country's general population. This study aims to describe the survival outcomes and clinicopathologic characteristics of patients with breast cancer at our Center.METHODSA retrospective cohort of patients with breast cancer treated between January 2012 and December 2020 was conducted. Survival outcomes were assessed using the Kaplan-Meier method. Univariate and multivariate analyses were performed using a Cox proportional hazards model.RESULTSThere were 5,264 patients included with a median follow-up of 54.9 months. Forty-three percent (n = 2,274) were diagnosed in stage I-IIA, 43.1% (n = 2,269) in stage IIB-III, and 7% (n = 383) in stage IV. At 5 years, disease-free survival was 74.9% (95% CI, 73.5 to 76.3) and overall survival (OS) 90.4% (95% CI, 89.4 to 91.3). For stage IV, it was 22.7% (95% CI, 17.3 to 28.5). High histologic grade (hazard ratio, 1.51 [95% CI, 1.34 to 1.7]; P < .001) and lymphovascular invasion (LVI; hazard ratio, 1.85 [95% CI, 1.62 to 2.1]; P < .001) were associated with a higher risk of recurrence.CONCLUSIONHistologic grade and LVI should be considered in the decision to treat with adjuvant chemotherapy in sites where genomic signatures are not available. Our OS data are comparable with other Mexican series; however, it is lower in stage IV. Much remains to be done at the national level, mainly regarding access to additional therapies for each breast cancer subtype. This work contributes to the evaluation of areas for improvement in outcomes in our population.https://ascopubs.org/doi/10.1200/GO.23.00233 |
| spellingShingle | Rocio Grajales-Alvarez Alicia Gutiérrez-Mata Christian Pichardo-Piña Marcos Gutiérrez-De la Barrera Karim Dip-Borunda Survival Outcomes of Patients With Breast Cancer in a Mexican Population JCO Global Oncology |
| title | Survival Outcomes of Patients With Breast Cancer in a Mexican Population |
| title_full | Survival Outcomes of Patients With Breast Cancer in a Mexican Population |
| title_fullStr | Survival Outcomes of Patients With Breast Cancer in a Mexican Population |
| title_full_unstemmed | Survival Outcomes of Patients With Breast Cancer in a Mexican Population |
| title_short | Survival Outcomes of Patients With Breast Cancer in a Mexican Population |
| title_sort | survival outcomes of patients with breast cancer in a mexican population |
| url | https://ascopubs.org/doi/10.1200/GO.23.00233 |
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