Cerebrospinal fluid microRNAs as potential biomarkers in Alzheimer’s disease
Alzheimer’s disease (AD) is the leading form of dementia worldwide, but its early detection and diagnosis remain a challenge. MicroRNAs (miRNAs) are a group of small endogenous RNA molecules that regulate mRNA expression. Recent evidence suggests miRNAs play an important role in the five major hallm...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1210191/full |
| _version_ | 1797786880907935744 |
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| author | Ahmed Noor Eddin Khaled Hamsho Ghaith Adi Mohammed Al-Rimawi Mohammed Alfuwais Saleha Abdul Rab Khaled Alkattan Ahmed Yaqinuddin |
| author_facet | Ahmed Noor Eddin Khaled Hamsho Ghaith Adi Mohammed Al-Rimawi Mohammed Alfuwais Saleha Abdul Rab Khaled Alkattan Ahmed Yaqinuddin |
| author_sort | Ahmed Noor Eddin |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is the leading form of dementia worldwide, but its early detection and diagnosis remain a challenge. MicroRNAs (miRNAs) are a group of small endogenous RNA molecules that regulate mRNA expression. Recent evidence suggests miRNAs play an important role in the five major hallmarks of AD pathophysiology: amyloidogenesis, tauopathy, neuroinflammation, synaptic dysfunction, and neuronal death. Compared to traditional biomarkers of AD, miRNAs display a greater degree of stability in cerebrospinal fluid. Moreover, aberrant changes in miRNA expression can be measured over time to monitor and guide patient treatment. Specific miRNA profiles and combinations may also be used to distinguish AD subjects from normal controls and other causes of dementia. Because of these properties, miRNAs are now being considered as promising and potential biomarkers of AD. This review comprehensively summarizes the diagnostic potential and regulatory roles miRNAs play in AD. |
| first_indexed | 2024-03-13T01:15:06Z |
| format | Article |
| id | doaj.art-e7a230f564084d7492960068261e3ba5 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-03-13T01:15:06Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-e7a230f564084d7492960068261e3ba52023-07-05T12:35:42ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-07-011510.3389/fnagi.2023.12101911210191Cerebrospinal fluid microRNAs as potential biomarkers in Alzheimer’s diseaseAhmed Noor EddinKhaled HamshoGhaith AdiMohammed Al-RimawiMohammed AlfuwaisSaleha Abdul RabKhaled AlkattanAhmed YaqinuddinAlzheimer’s disease (AD) is the leading form of dementia worldwide, but its early detection and diagnosis remain a challenge. MicroRNAs (miRNAs) are a group of small endogenous RNA molecules that regulate mRNA expression. Recent evidence suggests miRNAs play an important role in the five major hallmarks of AD pathophysiology: amyloidogenesis, tauopathy, neuroinflammation, synaptic dysfunction, and neuronal death. Compared to traditional biomarkers of AD, miRNAs display a greater degree of stability in cerebrospinal fluid. Moreover, aberrant changes in miRNA expression can be measured over time to monitor and guide patient treatment. Specific miRNA profiles and combinations may also be used to distinguish AD subjects from normal controls and other causes of dementia. Because of these properties, miRNAs are now being considered as promising and potential biomarkers of AD. This review comprehensively summarizes the diagnostic potential and regulatory roles miRNAs play in AD.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1210191/fullAlzheimer’s diseaseneurodegenerative disorderdementiaMicroRNAscerebrospinal fluiddiagnosis |
| spellingShingle | Ahmed Noor Eddin Khaled Hamsho Ghaith Adi Mohammed Al-Rimawi Mohammed Alfuwais Saleha Abdul Rab Khaled Alkattan Ahmed Yaqinuddin Cerebrospinal fluid microRNAs as potential biomarkers in Alzheimer’s disease Frontiers in Aging Neuroscience Alzheimer’s disease neurodegenerative disorder dementia MicroRNAs cerebrospinal fluid diagnosis |
| title | Cerebrospinal fluid microRNAs as potential biomarkers in Alzheimer’s disease |
| title_full | Cerebrospinal fluid microRNAs as potential biomarkers in Alzheimer’s disease |
| title_fullStr | Cerebrospinal fluid microRNAs as potential biomarkers in Alzheimer’s disease |
| title_full_unstemmed | Cerebrospinal fluid microRNAs as potential biomarkers in Alzheimer’s disease |
| title_short | Cerebrospinal fluid microRNAs as potential biomarkers in Alzheimer’s disease |
| title_sort | cerebrospinal fluid micrornas as potential biomarkers in alzheimer s disease |
| topic | Alzheimer’s disease neurodegenerative disorder dementia MicroRNAs cerebrospinal fluid diagnosis |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1210191/full |
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