Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations
Abstract Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal performance in non-European ancestry populations, li...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-41819-0 |
| _version_ | 1797558487252729856 |
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| author | Minta Thomas Yu-Ru Su Elisabeth A. Rosenthal Lori C. Sakoda Stephanie L. Schmit Maria N. Timofeeva Zhishan Chen Ceres Fernandez-Rozadilla Philip J. Law Neil Murphy Robert Carreras-Torres Virginia Diez-Obrero Franzel J. B. van Duijnhoven Shangqing Jiang Aesun Shin Alicja Wolk Amanda I. Phipps Andrea Burnett-Hartman Andrea Gsur Andrew T. Chan Ann G. Zauber Anna H. Wu Annika Lindblom Caroline Y. Um Catherine M. Tangen Chris Gignoux Christina Newton Christopher A. Haiman Conghui Qu D. Timothy Bishop Daniel D. Buchanan David R. Crosslin David V. Conti Dong-Hyun Kim Elizabeth Hauser Emily White Erin Siegel Fredrick R. Schumacher Gad Rennert Graham G. Giles Heather Hampel Hermann Brenner Isao Oze Jae Hwan Oh Jeffrey K. Lee Jennifer L. Schneider Jenny Chang-Claude Jeongseon Kim Jeroen R. Huyghe Jiayin Zheng Jochen Hampe Joel Greenson John L. Hopper Julie R. Palmer Kala Visvanathan Keitaro Matsuo Koichi Matsuda Keum Ji Jung Li Li Loic Le Marchand Ludmila Vodickova Luis Bujanda Marc J. Gunter Marco Matejcic Mark A. Jenkins Martha L. Slattery Mauro D’Amato Meilin Wang Michael Hoffmeister Michael O. Woods Michelle Kim Mingyang Song Motoki Iwasaki Mulong Du Natalia Udaltsova Norie Sawada Pavel Vodicka Peter T. Campbell Polly A. Newcomb Qiuyin Cai Rachel Pearlman Rish K. Pai Robert E. Schoen Robert S. Steinfelder Robert W. Haile Rosita Vandenputtelaar Ross L. Prentice Sébastien Küry Sergi Castellví-Bel Shoichiro Tsugane Sonja I. Berndt Soo Chin Lee Stefanie Brezina Stephanie J. Weinstein Stephen J. Chanock Sun Ha Jee Sun-Seog Kweon Susan Vadaparampil Tabitha A. Harrison Taiki Yamaji Temitope O. Keku Veronika Vymetalkova Volker Arndt Wei-Hua Jia Xiao-Ou Shu Yi Lin Yoon-Ok Ahn Zsofia K. Stadler Bethany Van Guelpen Cornelia M. Ulrich Elizabeth A. Platz John D. Potter Christopher I. Li Reinier Meester Victor Moreno Jane C. Figueiredo Graham Casey Iris Lansdorp Vogelaar Malcolm G. Dunlop Stephen B. Gruber Richard B. Hayes Paul D. P. Pharoah Richard S. Houlston Gail P. Jarvik Ian P. Tomlinson Wei Zheng Douglas A. Corley Ulrike Peters Li Hsu |
| author_facet | Minta Thomas Yu-Ru Su Elisabeth A. Rosenthal Lori C. Sakoda Stephanie L. Schmit Maria N. Timofeeva Zhishan Chen Ceres Fernandez-Rozadilla Philip J. Law Neil Murphy Robert Carreras-Torres Virginia Diez-Obrero Franzel J. B. van Duijnhoven Shangqing Jiang Aesun Shin Alicja Wolk Amanda I. Phipps Andrea Burnett-Hartman Andrea Gsur Andrew T. Chan Ann G. Zauber Anna H. Wu Annika Lindblom Caroline Y. Um Catherine M. Tangen Chris Gignoux Christina Newton Christopher A. Haiman Conghui Qu D. Timothy Bishop Daniel D. Buchanan David R. Crosslin David V. Conti Dong-Hyun Kim Elizabeth Hauser Emily White Erin Siegel Fredrick R. Schumacher Gad Rennert Graham G. Giles Heather Hampel Hermann Brenner Isao Oze Jae Hwan Oh Jeffrey K. Lee Jennifer L. Schneider Jenny Chang-Claude Jeongseon Kim Jeroen R. Huyghe Jiayin Zheng Jochen Hampe Joel Greenson John L. Hopper Julie R. Palmer Kala Visvanathan Keitaro Matsuo Koichi Matsuda Keum Ji Jung Li Li Loic Le Marchand Ludmila Vodickova Luis Bujanda Marc J. Gunter Marco Matejcic Mark A. Jenkins Martha L. Slattery Mauro D’Amato Meilin Wang Michael Hoffmeister Michael O. Woods Michelle Kim Mingyang Song Motoki Iwasaki Mulong Du Natalia Udaltsova Norie Sawada Pavel Vodicka Peter T. Campbell Polly A. Newcomb Qiuyin Cai Rachel Pearlman Rish K. Pai Robert E. Schoen Robert S. Steinfelder Robert W. Haile Rosita Vandenputtelaar Ross L. Prentice Sébastien Küry Sergi Castellví-Bel Shoichiro Tsugane Sonja I. Berndt Soo Chin Lee Stefanie Brezina Stephanie J. Weinstein Stephen J. Chanock Sun Ha Jee Sun-Seog Kweon Susan Vadaparampil Tabitha A. Harrison Taiki Yamaji Temitope O. Keku Veronika Vymetalkova Volker Arndt Wei-Hua Jia Xiao-Ou Shu Yi Lin Yoon-Ok Ahn Zsofia K. Stadler Bethany Van Guelpen Cornelia M. Ulrich Elizabeth A. Platz John D. Potter Christopher I. Li Reinier Meester Victor Moreno Jane C. Figueiredo Graham Casey Iris Lansdorp Vogelaar Malcolm G. Dunlop Stephen B. Gruber Richard B. Hayes Paul D. P. Pharoah Richard S. Houlston Gail P. Jarvik Ian P. Tomlinson Wei Zheng Douglas A. Corley Ulrike Peters Li Hsu |
| author_sort | Minta Thomas |
| collection | DOAJ |
| description | Abstract Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal performance in non-European ancestry populations, limiting their utility among these populations. Towards addressing this deficiency, we expand PRS development for CRC by incorporating Asian ancestry data (21,731 cases; 47,444 controls) into European ancestry training datasets (78,473 cases; 107,143 controls). The AUC estimates (95% CI) of PRS are 0.63(0.62-0.64), 0.59(0.57-0.61), 0.62(0.60-0.63), and 0.65(0.63-0.66) in independent datasets including 1681-3651 cases and 8696-115,105 controls of Asian, Black/African American, Latinx/Hispanic, and non-Hispanic White, respectively. They are significantly better than the European-centric PRS in all four major US racial and ethnic groups (p-values < 0.05). Further inclusion of non-European ancestry populations, especially Black/African American and Latinx/Hispanic, is needed to improve the risk prediction and enhance equity in applying PRS in clinical practice. |
| first_indexed | 2024-03-10T17:32:06Z |
| format | Article |
| id | doaj.art-e7a280372db24e62a96e2b247dd52766 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-10T17:32:06Z |
| publishDate | 2023-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e7a280372db24e62a96e2b247dd527662023-11-20T10:00:34ZengNature PortfolioNature Communications2041-17232023-10-0114111310.1038/s41467-023-41819-0Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populationsMinta Thomas0Yu-Ru Su1Elisabeth A. Rosenthal2Lori C. Sakoda3Stephanie L. Schmit4Maria N. Timofeeva5Zhishan Chen6Ceres Fernandez-Rozadilla7Philip J. Law8Neil Murphy9Robert Carreras-Torres10Virginia Diez-Obrero11Franzel J. B. van Duijnhoven12Shangqing Jiang13Aesun Shin14Alicja Wolk15Amanda I. Phipps16Andrea Burnett-Hartman17Andrea Gsur18Andrew T. Chan19Ann G. Zauber20Anna H. Wu21Annika Lindblom22Caroline Y. Um23Catherine M. Tangen24Chris Gignoux25Christina Newton26Christopher A. Haiman27Conghui Qu28D. Timothy Bishop29Daniel D. Buchanan30David R. Crosslin31David V. Conti32Dong-Hyun Kim33Elizabeth Hauser34Emily White35Erin Siegel36Fredrick R. Schumacher37Gad Rennert38Graham G. Giles39Heather Hampel40Hermann Brenner41Isao Oze42Jae Hwan Oh43Jeffrey K. Lee44Jennifer L. Schneider45Jenny Chang-Claude46Jeongseon Kim47Jeroen R. Huyghe48Jiayin Zheng49Jochen Hampe50Joel Greenson51John L. Hopper52Julie R. Palmer53Kala Visvanathan54Keitaro Matsuo55Koichi Matsuda56Keum Ji Jung57Li Li58Loic Le Marchand59Ludmila Vodickova60Luis Bujanda61Marc J. Gunter62Marco Matejcic63Mark A. Jenkins64Martha L. Slattery65Mauro D’Amato66Meilin Wang67Michael Hoffmeister68Michael O. Woods69Michelle Kim70Mingyang Song71Motoki Iwasaki72Mulong Du73Natalia Udaltsova74Norie Sawada75Pavel Vodicka76Peter T. Campbell77Polly A. Newcomb78Qiuyin Cai79Rachel Pearlman80Rish K. Pai81Robert E. Schoen82Robert S. Steinfelder83Robert W. Haile84Rosita Vandenputtelaar85Ross L. Prentice86Sébastien Küry87Sergi Castellví-Bel88Shoichiro Tsugane89Sonja I. Berndt90Soo Chin Lee91Stefanie Brezina92Stephanie J. Weinstein93Stephen J. Chanock94Sun Ha Jee95Sun-Seog Kweon96Susan Vadaparampil97Tabitha A. Harrison98Taiki Yamaji99Temitope O. Keku100Veronika Vymetalkova101Volker Arndt102Wei-Hua Jia103Xiao-Ou Shu104Yi Lin105Yoon-Ok Ahn106Zsofia K. Stadler107Bethany Van Guelpen108Cornelia M. Ulrich109Elizabeth A. Platz110John D. Potter111Christopher I. Li112Reinier Meester113Victor Moreno114Jane C. Figueiredo115Graham Casey116Iris Lansdorp Vogelaar117Malcolm G. Dunlop118Stephen B. Gruber119Richard B. Hayes120Paul D. P. Pharoah121Richard S. Houlston122Gail P. Jarvik123Ian P. Tomlinson124Wei Zheng125Douglas A. Corley126Ulrike Peters127Li Hsu128Public Health Sciences Division, Fred Hutchinson Cancer CenterPublic Health Sciences Division, Fred Hutchinson Cancer CenterDepartment of Medicine (Medical Genetics), University of Washington Medical CenterPublic Health Sciences Division, Fred Hutchinson Cancer CenterGenomic Medicine Institute, Cleveland ClinicDanish Institute for Advanced Study (DIAS), Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern DenmarkDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical CenterInstituto de Investigacion Sanitaria de Santiago (IDIS), Choupana snDivision of Genetics and Epidemiology, The Institute of Cancer ReseachNutrition and Metabolism Branch, International Agency for Research on Cancer, World Health OrganizationDigestive Diseases and Microbiota Group, Girona Biomedical Research Institute (IDIBGI)Unit of Biomarkers and Susceptibility, Oncology Data Analytics Program, Catalan Institute of OncologyDivision of Human Nutrition and Health, Wageningen University & ResearchPublic Health Sciences Division, Fred Hutchinson Cancer CenterDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul National University Cancer Research InstituteInstitute of Environmental Medicine, Karolinska InstitutetPublic Health Sciences Division, Fred Hutchinson Cancer CenterInstitute for Health Research, Kaiser Permanente Colorado.Center for Cancer Research, Medical University ViennaDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical SchoolDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer CenterUniversity of Southern California, Preventative MedicineDepartment of Clinical Genetics, Karolinska University HospitalDepartment of Population Science, American Cancer SocietySWOG Statistical Center, Fred Hutchinson Cancer Research CenterColorado Center for Personalized Medicine, University of Colorado - Anschutz Medical CampusDepartment of Population Science, American Cancer SocietyDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern CaliforniaPublic Health Sciences Division, Fred Hutchinson Cancer CenterLeeds Institute of Cancer and Pathology, University of LeedsColorectal Oncogenomics Group, Department of Clinical Pathology, The University of MelbourneDepartment of Bioinformatics and Medical Education, University of Washington Medical CenterDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern CaliforniaDepartment of Social and Preventive Medicine, Hallym University College of MedicineVA Cooperative Studies Program Epidemiology Center, Durham Veterans Affairs Health Care SystemPublic Health Sciences Division, Fred Hutchinson Cancer CenterCancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research InstituteDepartment of Population and Quantitative Health Sciences, Case Western Reserve UniversityDepartment of Community Medicine and Epidemiology, Lady Davis Carmel Medical CenterCancer Epidemiology Division, Cancer Council VictoriaDivision of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer CenterDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ).Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute.Research Institute and Hospital, National Cancer Center.Department of Gastroenterology, Kaiser Permanente San Francisco Medical CenterDivision of Research, Kaiser Permanente Northern CaliforniaDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ)Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer CenterPublic Health Sciences Division, Fred Hutchinson Cancer CenterPublic Health Sciences Division, Fred Hutchinson Cancer CenterDepartment of Medicine I, University Hospital Dresden, Technische Universität Dresden (TU Dresden)Department of Pathology, University of MichiganCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of MelbourneSlone Epidemiology Center, School of Medicine, Boston UniversityDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public HealthDivision of Molecular and Clinical Epidemiology, Aichi Cancer Center Research InstituteLaboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of TokyoInstitute for Health Promotion, Graduate School of Public Health, Yonsei UniversityDepartment of Family Medicine, University of VirginiaUniversity of Hawaii Cancer CenterDepartment of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of SciencesDepartment of Gastroenterology, Biodonostia Health Research Institute, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Universidad del País Vasco (UPV/EHU)Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health OrganizationMoffitt Cancer CenterUniversity of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer CentreDepartment of Internal Medicine, University of UtahDepartment of Medicine and Surgery, LUM UniversityDepartment of Environmental Genomics, School of Public Health, Nanjing Medical UniversityDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)Memorial University of Newfoundland, Discipline of GeneticsPublic Health Sciences Division, Fred Hutchinson Cancer CenterDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical SchoolDivision of Epidemiology, National Cancer Center Institute for Cancer Control, National Cancer CenterDepartment of Biostatistics, School of Public Health, Nanjing Medical UniversityDivision of Research, Kaiser Permanente Northern CaliforniaDivision of Cohort Research, National Cancer Center Institute for Cancer Control, National Cancer CenterDepartment of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of SciencesDepartment of Epidemiology and Population Health, Albert Einstein College of MedicinePublic Health Sciences Division, Fred Hutchinson Cancer CenterDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical CenterDivision of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer CenterDepartment of Laboratory Medicine and Pathology, Mayo Clinic ArizonaDepartment of Medicine and Epidemiology, University of Pittsburgh Medical CenterPublic Health Sciences Division, Fred Hutchinson Cancer CenterSamuel Oschin Comprehensive Cancer Institute, CEDARS-SINAIDepartment of Public Health, Erasmus University Medical CenterPublic Health Sciences Division, Fred Hutchinson Cancer CenterNantes Université, CHU Nantes, Service de Génétique MédicaleGastroenterology Department, Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of BarcelonaDivision of Cohort Research, National Cancer Center Institute for Cancer Control, National Cancer CenterDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of HealthNational University Cancer Institute.Center for Cancer Research, Medical University ViennaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of HealthDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of HealthDepartment of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei UniversityDepartment of Preventive Medicine, Chonnam National University Medical SchoolDepartments of Epidemiology and Nutrition, Harvard TH Chan School of Public HealthPublic Health Sciences Division, Fred Hutchinson Cancer CenterDivision of Epidemiology, National Cancer Center Institute for Cancer Control, National Cancer CenterCenter for Gastrointestinal Biology and Disease, University of North CarolinaDepartment of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of SciencesDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen UniversityVanderbilt University Medical CenterPublic Health Sciences Division, Fred Hutchinson Cancer CenterDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul National University Cancer Research InstituteDepartment of Medicine, Memorial Sloan Kettering Cancer CenterDepartment of Radiation Sciences, Oncology Unit, Umeå UniversityHuntsman Cancer Institute and Department of Population Health Sciences, University of UtahDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public HealthPublic Health Sciences Division, Fred Hutchinson Cancer CenterPublic Health Sciences Division, Fred Hutchinson Cancer CenterDepartment of Public Health, Erasmus University Medical CenterOncology Data Analytics Program, Catalan Institute of Oncology-IDIBELL, L’Hospitalet de LlobregatDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern CaliforniaCenter for Public Health Genomics, University of VirginiaDepartment of Public Health, Erasmus University Medical CenterColon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of EdinburghDepartment of Medical Oncology & Therapeutics Research, City of Hope National Medical CenterDivision of Epidemiology, Department of Population Health, New York University School of MedicineDepartment of Public Health and Primary Care, University of CambridgeDivision of Genetics and Epidemiology, The Institute of Cancer ReseachDepartment of Medicine (Medical Genetics), University of Washington Medical CenterEdinburgh Cancer Research Centre, Institute of Genomics and Cancer, University of EdinburghDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical CenterDivision of Research, Kaiser Permanente Northern CaliforniaPublic Health Sciences Division, Fred Hutchinson Cancer CenterPublic Health Sciences Division, Fred Hutchinson Cancer CenterAbstract Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal performance in non-European ancestry populations, limiting their utility among these populations. Towards addressing this deficiency, we expand PRS development for CRC by incorporating Asian ancestry data (21,731 cases; 47,444 controls) into European ancestry training datasets (78,473 cases; 107,143 controls). The AUC estimates (95% CI) of PRS are 0.63(0.62-0.64), 0.59(0.57-0.61), 0.62(0.60-0.63), and 0.65(0.63-0.66) in independent datasets including 1681-3651 cases and 8696-115,105 controls of Asian, Black/African American, Latinx/Hispanic, and non-Hispanic White, respectively. They are significantly better than the European-centric PRS in all four major US racial and ethnic groups (p-values < 0.05). Further inclusion of non-European ancestry populations, especially Black/African American and Latinx/Hispanic, is needed to improve the risk prediction and enhance equity in applying PRS in clinical practice.https://doi.org/10.1038/s41467-023-41819-0 |
| spellingShingle | Minta Thomas Yu-Ru Su Elisabeth A. Rosenthal Lori C. Sakoda Stephanie L. Schmit Maria N. Timofeeva Zhishan Chen Ceres Fernandez-Rozadilla Philip J. Law Neil Murphy Robert Carreras-Torres Virginia Diez-Obrero Franzel J. B. van Duijnhoven Shangqing Jiang Aesun Shin Alicja Wolk Amanda I. Phipps Andrea Burnett-Hartman Andrea Gsur Andrew T. Chan Ann G. Zauber Anna H. Wu Annika Lindblom Caroline Y. Um Catherine M. Tangen Chris Gignoux Christina Newton Christopher A. Haiman Conghui Qu D. Timothy Bishop Daniel D. Buchanan David R. Crosslin David V. Conti Dong-Hyun Kim Elizabeth Hauser Emily White Erin Siegel Fredrick R. Schumacher Gad Rennert Graham G. Giles Heather Hampel Hermann Brenner Isao Oze Jae Hwan Oh Jeffrey K. Lee Jennifer L. Schneider Jenny Chang-Claude Jeongseon Kim Jeroen R. Huyghe Jiayin Zheng Jochen Hampe Joel Greenson John L. Hopper Julie R. Palmer Kala Visvanathan Keitaro Matsuo Koichi Matsuda Keum Ji Jung Li Li Loic Le Marchand Ludmila Vodickova Luis Bujanda Marc J. Gunter Marco Matejcic Mark A. Jenkins Martha L. Slattery Mauro D’Amato Meilin Wang Michael Hoffmeister Michael O. Woods Michelle Kim Mingyang Song Motoki Iwasaki Mulong Du Natalia Udaltsova Norie Sawada Pavel Vodicka Peter T. Campbell Polly A. Newcomb Qiuyin Cai Rachel Pearlman Rish K. Pai Robert E. Schoen Robert S. Steinfelder Robert W. Haile Rosita Vandenputtelaar Ross L. Prentice Sébastien Küry Sergi Castellví-Bel Shoichiro Tsugane Sonja I. Berndt Soo Chin Lee Stefanie Brezina Stephanie J. Weinstein Stephen J. Chanock Sun Ha Jee Sun-Seog Kweon Susan Vadaparampil Tabitha A. Harrison Taiki Yamaji Temitope O. Keku Veronika Vymetalkova Volker Arndt Wei-Hua Jia Xiao-Ou Shu Yi Lin Yoon-Ok Ahn Zsofia K. Stadler Bethany Van Guelpen Cornelia M. Ulrich Elizabeth A. Platz John D. Potter Christopher I. Li Reinier Meester Victor Moreno Jane C. Figueiredo Graham Casey Iris Lansdorp Vogelaar Malcolm G. Dunlop Stephen B. Gruber Richard B. Hayes Paul D. P. Pharoah Richard S. Houlston Gail P. Jarvik Ian P. Tomlinson Wei Zheng Douglas A. Corley Ulrike Peters Li Hsu Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations Nature Communications |
| title | Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations |
| title_full | Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations |
| title_fullStr | Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations |
| title_full_unstemmed | Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations |
| title_short | Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations |
| title_sort | combining asian and european genome wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations |
| url | https://doi.org/10.1038/s41467-023-41819-0 |
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