Ectopic pituitary neuroendocrine tumor arising in the sphenoid sinus with an avid 18F-fluorodeoxyglucose uptake masquerading as malignancy: A case report
Ectopic pituitary neuroendocrine tumors (PitNETs) are uncommon conditions that develop outside of the sella turcica. The sphenoid sinus is the most common site for ectopic PitNET, followed by the suprasellar region, clivus, and cavernous sinus. PitNETs, regardless of whether inside or outside sella,...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Radiology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1930043323003564 |
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| author | Yukiko Usui, MD Ryo Kurokawa, MD, PhD Takahiro Fukushima, MD Richi Fujita, MD Reina Hosoi, MD Emi Miyawaki, MD Michio Hayashi, MD Sadahiro Kishisita, MD Mariko Kurokawa, MD Osamu Abe, MD, PhD Haruyasu Yamada, MD, PhD |
| author_facet | Yukiko Usui, MD Ryo Kurokawa, MD, PhD Takahiro Fukushima, MD Richi Fujita, MD Reina Hosoi, MD Emi Miyawaki, MD Michio Hayashi, MD Sadahiro Kishisita, MD Mariko Kurokawa, MD Osamu Abe, MD, PhD Haruyasu Yamada, MD, PhD |
| author_sort | Yukiko Usui, MD |
| collection | DOAJ |
| description | Ectopic pituitary neuroendocrine tumors (PitNETs) are uncommon conditions that develop outside of the sella turcica. The sphenoid sinus is the most common site for ectopic PitNET, followed by the suprasellar region, clivus, and cavernous sinus. PitNETs, regardless of whether inside or outside sella, may display avid 18F-fluorodeoxyglucose (FDG) uptake and masquerade as malignant tumors. Herein, we report a case of ectopic PitNET arising in the sphenoid sinus, which was found as an FDG-avid mass during cancer screening. On magnetic resonance imaging, the tumor showed heterogeneous and intermediate signal intensity areas on T1- and T2-weighted images with cystic components, which was consistent with PitNET. The localization and the presence of empty sella were suggestive of ectopic PitNET, and the diagnosis of ectopic PitNET (prolactinoma) was confirmed by endoscopic biopsy. Ectopic PitNET should be considered in a mass similar in nature to an orthogonal PitNET in areas near the sella turcica especially in patients with empty sella. |
| first_indexed | 2024-03-12T22:23:10Z |
| format | Article |
| id | doaj.art-e7a3ce66459f4b068a0e935958885959 |
| institution | Directory Open Access Journal |
| issn | 1930-0433 |
| language | English |
| last_indexed | 2024-03-12T22:23:10Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj.art-e7a3ce66459f4b068a0e9359588859592023-07-23T04:54:02ZengElsevierRadiology Case Reports1930-04332023-09-0118929432947Ectopic pituitary neuroendocrine tumor arising in the sphenoid sinus with an avid 18F-fluorodeoxyglucose uptake masquerading as malignancy: A case reportYukiko Usui, MD0Ryo Kurokawa, MD, PhD1Takahiro Fukushima, MD2Richi Fujita, MD3Reina Hosoi, MD4Emi Miyawaki, MD5Michio Hayashi, MD6Sadahiro Kishisita, MD7Mariko Kurokawa, MD8Osamu Abe, MD, PhD9Haruyasu Yamada, MD, PhD10Department of Radiology, NTT Medical Center Tokyo, Shinagawa-ku, Tokyo, Japan; Department of Radiology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, JapanDepartment of Radiology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan; Corresponding author.Department of Radiology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, JapanDepartment of Radiology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, JapanDepartment of Radiology, NTT Medical Center Tokyo, Shinagawa-ku, Tokyo, JapanDepartment of Radiology, NTT Medical Center Tokyo, Shinagawa-ku, Tokyo, JapanDepartment of Diabetes and Endocrinology, NTT Medical Center Tokyo, Shinagawa-ku, Tokyo, JapanDepartment of Otorhinolaryngology-Head and Neck Surgery, NTT Medical Center Tokyo, Shinagawa-ku, Tokyo, JapanDepartment of Radiology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, JapanDepartment of Radiology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, JapanDepartment of Radiology, NTT Medical Center Tokyo, Shinagawa-ku, Tokyo, JapanEctopic pituitary neuroendocrine tumors (PitNETs) are uncommon conditions that develop outside of the sella turcica. The sphenoid sinus is the most common site for ectopic PitNET, followed by the suprasellar region, clivus, and cavernous sinus. PitNETs, regardless of whether inside or outside sella, may display avid 18F-fluorodeoxyglucose (FDG) uptake and masquerade as malignant tumors. Herein, we report a case of ectopic PitNET arising in the sphenoid sinus, which was found as an FDG-avid mass during cancer screening. On magnetic resonance imaging, the tumor showed heterogeneous and intermediate signal intensity areas on T1- and T2-weighted images with cystic components, which was consistent with PitNET. The localization and the presence of empty sella were suggestive of ectopic PitNET, and the diagnosis of ectopic PitNET (prolactinoma) was confirmed by endoscopic biopsy. Ectopic PitNET should be considered in a mass similar in nature to an orthogonal PitNET in areas near the sella turcica especially in patients with empty sella.http://www.sciencedirect.com/science/article/pii/S1930043323003564Ectopic PitNETEctopic pituitary adenomaSphenoid sinus18F-fluorodeoxyglucose uptake18F-FDG PET/CT |
| spellingShingle | Yukiko Usui, MD Ryo Kurokawa, MD, PhD Takahiro Fukushima, MD Richi Fujita, MD Reina Hosoi, MD Emi Miyawaki, MD Michio Hayashi, MD Sadahiro Kishisita, MD Mariko Kurokawa, MD Osamu Abe, MD, PhD Haruyasu Yamada, MD, PhD Ectopic pituitary neuroendocrine tumor arising in the sphenoid sinus with an avid 18F-fluorodeoxyglucose uptake masquerading as malignancy: A case report Radiology Case Reports Ectopic PitNET Ectopic pituitary adenoma Sphenoid sinus 18F-fluorodeoxyglucose uptake 18F-FDG PET/CT |
| title | Ectopic pituitary neuroendocrine tumor arising in the sphenoid sinus with an avid 18F-fluorodeoxyglucose uptake masquerading as malignancy: A case report |
| title_full | Ectopic pituitary neuroendocrine tumor arising in the sphenoid sinus with an avid 18F-fluorodeoxyglucose uptake masquerading as malignancy: A case report |
| title_fullStr | Ectopic pituitary neuroendocrine tumor arising in the sphenoid sinus with an avid 18F-fluorodeoxyglucose uptake masquerading as malignancy: A case report |
| title_full_unstemmed | Ectopic pituitary neuroendocrine tumor arising in the sphenoid sinus with an avid 18F-fluorodeoxyglucose uptake masquerading as malignancy: A case report |
| title_short | Ectopic pituitary neuroendocrine tumor arising in the sphenoid sinus with an avid 18F-fluorodeoxyglucose uptake masquerading as malignancy: A case report |
| title_sort | ectopic pituitary neuroendocrine tumor arising in the sphenoid sinus with an avid 18f fluorodeoxyglucose uptake masquerading as malignancy a case report |
| topic | Ectopic PitNET Ectopic pituitary adenoma Sphenoid sinus 18F-fluorodeoxyglucose uptake 18F-FDG PET/CT |
| url | http://www.sciencedirect.com/science/article/pii/S1930043323003564 |
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