Iron Metabolism in Obesity and Metabolic Syndrome
Obesity is an excessive adipose tissue accumulation that may have detrimental effects on health. Particularly, childhood obesity has become one of the main public health problems in the 21st century, since its prevalence has widely increased in recent years. Childhood obesity is intimately related t...
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| Format: | Article |
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MDPI AG
2020-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/15/5529 |
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| author | Álvaro González-Domínguez Francisco M. Visiedo-García Jesús Domínguez-Riscart Raúl González-Domínguez Rosa M. Mateos Alfonso María Lechuga-Sancho |
| author_facet | Álvaro González-Domínguez Francisco M. Visiedo-García Jesús Domínguez-Riscart Raúl González-Domínguez Rosa M. Mateos Alfonso María Lechuga-Sancho |
| author_sort | Álvaro González-Domínguez |
| collection | DOAJ |
| description | Obesity is an excessive adipose tissue accumulation that may have detrimental effects on health. Particularly, childhood obesity has become one of the main public health problems in the 21st century, since its prevalence has widely increased in recent years. Childhood obesity is intimately related to the development of several comorbidities such as nonalcoholic fatty liver disease, dyslipidemia, type 2 diabetes mellitus, non-congenital cardiovascular disease, chronic inflammation and anemia, among others. Within this tangled interplay between these comorbidities and associated pathological conditions, obesity has been closely linked to important perturbations in iron metabolism. Iron is the second most abundant metal on Earth, but its bioavailability is hampered by its ability to form highly insoluble oxides, with iron deficiency being the most common nutritional disorder. Although every living organism requires iron, it may also cause toxic oxygen damage by generating oxygen free radicals through the Fenton reaction. Thus, iron homeostasis and metabolism must be tightly regulated in humans at every level (i.e., absorption, storage, transport, recycling). Dysregulation of any step involved in iron metabolism may lead to iron deficiencies and, eventually, to the anemic state related to obesity. In this review article, we summarize the existent evidence on the role of the most recently described components of iron metabolism and their alterations in obesity. |
| first_indexed | 2024-03-10T18:02:40Z |
| format | Article |
| id | doaj.art-e7a4dd84143047c6b7b24fd71c4664f9 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T18:02:40Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e7a4dd84143047c6b7b24fd71c4664f92023-11-20T08:48:27ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-08-012115552910.3390/ijms21155529Iron Metabolism in Obesity and Metabolic SyndromeÁlvaro González-Domínguez0Francisco M. Visiedo-García1Jesús Domínguez-Riscart2Raúl González-Domínguez3Rosa M. Mateos4Alfonso María Lechuga-Sancho5Inflammation, Nutrition, Metabolism and Oxidative Stress Study Group (INMOX), Biomedical Research and Innovation Institute of Cádiz (INiBICA), Research Unit, Puerta del Mar University Hospital, 11009 Cádiz, SpainInflammation, Nutrition, Metabolism and Oxidative Stress Study Group (INMOX), Biomedical Research and Innovation Institute of Cádiz (INiBICA), Research Unit, Puerta del Mar University Hospital, 11009 Cádiz, SpainPediatric Endocrinology, Department of Pediatrics, Puerta del Mar University Hospital, 11009 Cádiz, SpainDepartment of Chemistry, Faculty of Experimental Sciences, University of Huelva, 21007 Huelva, SpainInflammation, Nutrition, Metabolism and Oxidative Stress Study Group (INMOX), Biomedical Research and Innovation Institute of Cádiz (INiBICA), Research Unit, Puerta del Mar University Hospital, 11009 Cádiz, SpainInflammation, Nutrition, Metabolism and Oxidative Stress Study Group (INMOX), Biomedical Research and Innovation Institute of Cádiz (INiBICA), Research Unit, Puerta del Mar University Hospital, 11009 Cádiz, SpainObesity is an excessive adipose tissue accumulation that may have detrimental effects on health. Particularly, childhood obesity has become one of the main public health problems in the 21st century, since its prevalence has widely increased in recent years. Childhood obesity is intimately related to the development of several comorbidities such as nonalcoholic fatty liver disease, dyslipidemia, type 2 diabetes mellitus, non-congenital cardiovascular disease, chronic inflammation and anemia, among others. Within this tangled interplay between these comorbidities and associated pathological conditions, obesity has been closely linked to important perturbations in iron metabolism. Iron is the second most abundant metal on Earth, but its bioavailability is hampered by its ability to form highly insoluble oxides, with iron deficiency being the most common nutritional disorder. Although every living organism requires iron, it may also cause toxic oxygen damage by generating oxygen free radicals through the Fenton reaction. Thus, iron homeostasis and metabolism must be tightly regulated in humans at every level (i.e., absorption, storage, transport, recycling). Dysregulation of any step involved in iron metabolism may lead to iron deficiencies and, eventually, to the anemic state related to obesity. In this review article, we summarize the existent evidence on the role of the most recently described components of iron metabolism and their alterations in obesity.https://www.mdpi.com/1422-0067/21/15/5529anemiachildhood obesityironmetabolic syndromemetabolismobesity |
| spellingShingle | Álvaro González-Domínguez Francisco M. Visiedo-García Jesús Domínguez-Riscart Raúl González-Domínguez Rosa M. Mateos Alfonso María Lechuga-Sancho Iron Metabolism in Obesity and Metabolic Syndrome International Journal of Molecular Sciences anemia childhood obesity iron metabolic syndrome metabolism obesity |
| title | Iron Metabolism in Obesity and Metabolic Syndrome |
| title_full | Iron Metabolism in Obesity and Metabolic Syndrome |
| title_fullStr | Iron Metabolism in Obesity and Metabolic Syndrome |
| title_full_unstemmed | Iron Metabolism in Obesity and Metabolic Syndrome |
| title_short | Iron Metabolism in Obesity and Metabolic Syndrome |
| title_sort | iron metabolism in obesity and metabolic syndrome |
| topic | anemia childhood obesity iron metabolic syndrome metabolism obesity |
| url | https://www.mdpi.com/1422-0067/21/15/5529 |
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