The Role of Apparent Diffusion Coefficient Quantification in Differentiating Benign and Malignant Renal Masses by 3 Tesla Magnetic Resonance Imaging
Background: Diffusion-weighted magnetic resonance imaging (DWI) is a widely-accepted diagnostic modality whose efficacy has been investigated by numerous past studies in the differentiation of malignant lesions from benign entities. Aims: The aim of this study was to evaluate the efficiency of di...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2015-09-01
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| Series: | Balkan Medical Journal |
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| Online Access: | http://balkanmedicaljournal.org/text.php?lang=en&id=199 |
| _version_ | 1797910270050304000 |
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| author | Cemil Göya Cihad Hamidi Salih Hattapoğlu Aslan Bilici Hatice Gümüş Yaşar Bozkurt Alpaslan Yavuz Suzan Kuday Gül Türkçü |
| author_facet | Cemil Göya Cihad Hamidi Salih Hattapoğlu Aslan Bilici Hatice Gümüş Yaşar Bozkurt Alpaslan Yavuz Suzan Kuday Gül Türkçü |
| author_sort | Cemil Göya |
| collection | DOAJ |
| description | Background: Diffusion-weighted magnetic resonance imaging (DWI) is a widely-accepted diagnostic modality whose efficacy has been investigated by numerous past studies in the differentiation of malignant lesions from benign entities.
Aims: The aim of this study was to evaluate the efficiency of diffusion-weighted magnetic resonance imaging in the characterization of renal lesions.
Study Design: Diagnostic accuracy study.
Methods: A total of 137 patients with renal lesions were included in this study. The median apparent diffusion coefficient (ADC) values as well as the b 800 and b 1600 signal intensities of normal kidneys, solid components of mixed renal masses, and total cystic lesions were evaluated.
Results: There were significant differences between the ADC values of lesions and normal renal parenchyma, and between the ADC values of benign and malignant renal lesions on DWIs at b values of 800 and 1600 s/mm² (p<0.001 and p<0.001, respectively). There were significant differences between the ADC values of Bosniak Category 1 and 2 cysts and the ADC values of Bosniak Category 1 and 3 cysts on DWIs at b values of 800 s/mm² (p<0.001) and 1600 s/mm2 (p<0.001). A cutoff value of 1.902 x 10-3 mm²/s for the ADC with a b value of 800 s/mm² provided 88% sensitivity and 96% specificity for differentiation between benign and malignant renal lesions. A cutoff value of 1.623 x 10-3 mm²/s for the ADC with a b value of 1600 s/mm² provided 79% sensitivity and 96% specificity (p<0.001) for the differentiation between benign and malignant renal lesions.
Conclusion: Accurate assessment of renal masses is important for determining the necessity for surgical intervention. DWI provides additional value by differentiating benign from malignant renal tumors and can be added to routine kidney MRI protocols. |
| first_indexed | 2024-04-10T11:21:39Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2146-3123 2146-3131 |
| language | English |
| last_indexed | 2024-04-10T11:21:39Z |
| publishDate | 2015-09-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Balkan Medical Journal |
| spelling | doaj.art-e7a6eda6fcc84d18bcf65097d536836e2023-02-15T16:18:36ZengGalenos Publishing HouseBalkan Medical Journal2146-31232146-31312015-09-0132327327810.5152/balkanmedj.2015.15475The Role of Apparent Diffusion Coefficient Quantification in Differentiating Benign and Malignant Renal Masses by 3 Tesla Magnetic Resonance ImagingCemil Göya0Cihad Hamidi1Salih Hattapoğlu2Aslan Bilici3Hatice Gümüş4Yaşar Bozkurt5Alpaslan Yavuz6Suzan Kuday7Gül Türkçü8Department of Radiology, Dicle University Faculty of Medicine, Diyarbakır, TurkeyDepartment of Radiology, Dicle University Faculty of Medicine, Diyarbakır, TurkeyDepartment of Radiology, Dicle University Faculty of Medicine, Diyarbakır, TurkeyDepartment of Radiology, Dicle University Faculty of Medicine, Diyarbakır, TurkeyDepartment of Radiology, Dicle University Faculty of Medicine, Diyarbakır, TurkeyDepartment of Urology, Dicle University Faculty of Medicine, Diyarbakır, TurkeyDepartment of Radiology, Yüzüncü Yıl University Faculty of Medicine, Van, TurkeyDepartment of Radiology, Bismil State Hospital, Diyarbakır, TurkeyDepartment of Pathology, Dicle University Faculty of Medicine, Diyarbakır, TurkeyBackground: Diffusion-weighted magnetic resonance imaging (DWI) is a widely-accepted diagnostic modality whose efficacy has been investigated by numerous past studies in the differentiation of malignant lesions from benign entities. Aims: The aim of this study was to evaluate the efficiency of diffusion-weighted magnetic resonance imaging in the characterization of renal lesions. Study Design: Diagnostic accuracy study. Methods: A total of 137 patients with renal lesions were included in this study. The median apparent diffusion coefficient (ADC) values as well as the b 800 and b 1600 signal intensities of normal kidneys, solid components of mixed renal masses, and total cystic lesions were evaluated. Results: There were significant differences between the ADC values of lesions and normal renal parenchyma, and between the ADC values of benign and malignant renal lesions on DWIs at b values of 800 and 1600 s/mm² (p<0.001 and p<0.001, respectively). There were significant differences between the ADC values of Bosniak Category 1 and 2 cysts and the ADC values of Bosniak Category 1 and 3 cysts on DWIs at b values of 800 s/mm² (p<0.001) and 1600 s/mm2 (p<0.001). A cutoff value of 1.902 x 10-3 mm²/s for the ADC with a b value of 800 s/mm² provided 88% sensitivity and 96% specificity for differentiation between benign and malignant renal lesions. A cutoff value of 1.623 x 10-3 mm²/s for the ADC with a b value of 1600 s/mm² provided 79% sensitivity and 96% specificity (p<0.001) for the differentiation between benign and malignant renal lesions. Conclusion: Accurate assessment of renal masses is important for determining the necessity for surgical intervention. DWI provides additional value by differentiating benign from malignant renal tumors and can be added to routine kidney MRI protocols.http://balkanmedicaljournal.org/text.php?lang=en&id=199Apparent diffusion coefficientdiffusion-weighted magnetic resonance imagingrenal neoplasms3 T MRI |
| spellingShingle | Cemil Göya Cihad Hamidi Salih Hattapoğlu Aslan Bilici Hatice Gümüş Yaşar Bozkurt Alpaslan Yavuz Suzan Kuday Gül Türkçü The Role of Apparent Diffusion Coefficient Quantification in Differentiating Benign and Malignant Renal Masses by 3 Tesla Magnetic Resonance Imaging Balkan Medical Journal Apparent diffusion coefficient diffusion-weighted magnetic resonance imaging renal neoplasms 3 T MRI |
| title | The Role of Apparent Diffusion Coefficient Quantification in Differentiating Benign and Malignant Renal Masses by 3 Tesla Magnetic Resonance Imaging |
| title_full | The Role of Apparent Diffusion Coefficient Quantification in Differentiating Benign and Malignant Renal Masses by 3 Tesla Magnetic Resonance Imaging |
| title_fullStr | The Role of Apparent Diffusion Coefficient Quantification in Differentiating Benign and Malignant Renal Masses by 3 Tesla Magnetic Resonance Imaging |
| title_full_unstemmed | The Role of Apparent Diffusion Coefficient Quantification in Differentiating Benign and Malignant Renal Masses by 3 Tesla Magnetic Resonance Imaging |
| title_short | The Role of Apparent Diffusion Coefficient Quantification in Differentiating Benign and Malignant Renal Masses by 3 Tesla Magnetic Resonance Imaging |
| title_sort | role of apparent diffusion coefficient quantification in differentiating benign and malignant renal masses by 3 tesla magnetic resonance imaging |
| topic | Apparent diffusion coefficient diffusion-weighted magnetic resonance imaging renal neoplasms 3 T MRI |
| url | http://balkanmedicaljournal.org/text.php?lang=en&id=199 |
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