Histopathological Correlations between Mediastinal Fat-Associated Lymphoid Clusters and the Development of Lung Inflammation and Fibrosis following Bleomycin Administration in Mice

Histopathological Correlations between Mediastinal Fat-Associated Lymphoid Clusters and the Development of Lung Inflammation and Fibrosis following Bleomycin Administration in Mice

Bleomycin (BLM) has been reported to induce lung inflammation and fibrosis in human and mice and showed genetic susceptibility. Interestingly, the C57BL/6 (B6) mice had prominent mediastinal fat-associated lymphoid cluster (MFALCs) under healthy condition, and showed susceptibility to development of...

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Bibliographic Details
Main Authors: Yaser Hosny Ali Elewa, Osamu Ichii, Kensuke Takada, Teppei Nakamura, Md. Abdul Masum, Yasuhiro Kon
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Immunology
Subjects:
bleomycin
lung inflammation
mediastinal fat-associated lymphoid cluster
mediastinal adipose tissue
C57BL/6 mice
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00271/full

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