Differences in disease severity but similar telomere lengths in genetic subgroups of patients with telomerase and shelterin mutations.
The bone marrow failure syndrome dyskeratosis congenita (DC) has been considered to be a disorder of telomere maintenance in which disease features arise due to accelerated shortening of telomeres. By screening core components of the telomerase and shelterin complexes in patients with DC and related...
Main Authors: | Tom J Vulliamy, Michael J Kirwan, Richard Beswick, Upal Hossain, Charlotte Baqai, Anna Ratcliffe, Judith Marsh, Amanda Walne, Inderjeet Dokal |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2011-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3172236?pdf=render |
Similar Items
-
Decreased telomere length in a subgroup of young individuals with bipolar disorders: replication in the FACE-BD cohort and association with the shelterin component POT1
by: Luana Spano, et al.
Published: (2024-03-01) -
Prognostic significance of dysregulation of shelterin complex and its correlation with telomere length and cytogenetics in multiple myeloma
by: Akanksha A. Kalal, et al.
Published: (2023-05-01) -
Condensin positioning at telomeres by shelterin proteins drives sister-telomere disjunction in anaphase
by: Léonard Colin, et al.
Published: (2023-11-01) -
Multifunctionality of the Telomere-Capping Shelterin Complex Explained by Variations in Its Protein Composition
by: Claire Ghilain, et al.
Published: (2021-07-01) -
Canine sperm motility is associated with telomere shortening and changes in expression of shelterin genes
by: Hossein Hassanpour, et al.
Published: (2023-11-01)