Perirenal fat thickness and liver fat fraction are independent predictors of MetS in adults with overweight and obesity suspected with NAFLD: a retrospective study
Abstract Background Nonalcoholic fatty liver disease (NAFLD) has a multidirectional relationship with metabolic syndrome (MetS) and used to be considered a hepatic manifestation of MetS. Perirenal fat, as a part of visceral adipose tissue (VAT), was reported to be correlated with MetS components, bu...
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | Diabetology & Metabolic Syndrome |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13098-023-01033-w |
| _version_ | 1827979479432036352 |
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| author | Li Wang Yuning Pan Xianwang Ye Yongmeng Zhu Yandong Lian Hui Zhang Miao Xu Mengxiao Liu Xinzhong Ruan |
| author_facet | Li Wang Yuning Pan Xianwang Ye Yongmeng Zhu Yandong Lian Hui Zhang Miao Xu Mengxiao Liu Xinzhong Ruan |
| author_sort | Li Wang |
| collection | DOAJ |
| description | Abstract Background Nonalcoholic fatty liver disease (NAFLD) has a multidirectional relationship with metabolic syndrome (MetS) and used to be considered a hepatic manifestation of MetS. Perirenal fat, as a part of visceral adipose tissue (VAT), was reported to be correlated with MetS components, but data for intraorgan fat are lacking. This study was undertaken to assess the value of peripheral and intraorgan fat to predict MetS in adults with overweight and obesity with suspected NAFLD. Methods We studied 134 sequential adults (mean age, 31.5 years; 47% female) with overweight and obesity with suspected NAFLD. All participants underwent abdominal magnetic resonance imaging (MRI) examination. Anthropometric and metabolic parameters and perirenal fat thickness (PRFT), subcutaneous adipose tissue thickness (SATT), liver fat fraction (LFF), pancreas fat fraction (PFF), and lumbar spine fat fraction (LSFF) were collected. MetS was defined according to the International Diabetes Federation (IDF) criteria. Statistical analyses included basic statistics, linear correlation and logistic regression analysis. Results A total of 63 adults with MetS and 71 adults with advanced liver steatosis (grades 2 and 3) were included in our study. Patients with MetS had greater PRFT (p = 0.026) and LFF (p < 0.001), as well as greater homeostasis model assessment of insulin resistance (HOMA-IR), alanine transaminase (ALT), aspartate transaminase (AST), and decreased SATT. MetS patients had a higher proportion of advanced steatosis than those without MetS (P < 0.001). The MetS score was associated with PRFT and LFF. Logistic regression analysis showed that the PRFT and LFF were independent predictors of MetS after adjusting for age and sex. A cutoff of 9.15 mm for PRFT and 14.68% for LFF could be predictive of MetS. Conclusions This study shows that the absolute cutoff level of 9.15 mm for PRFT and 14.68% for LFF may be clinically important markers for identifying patients who are at high risk of MetS among adults with overweight and obesity with suspected NAFLD, irrespective of sex and age. Moreover, ectopic fat levels in pancreas and lumbar spine are positively associated with PRFT. Trial registration Not applicable. |
| first_indexed | 2024-04-09T21:37:23Z |
| format | Article |
| id | doaj.art-e7a968d23b2c4588832fb3fdc4e46638 |
| institution | Directory Open Access Journal |
| issn | 1758-5996 |
| language | English |
| last_indexed | 2024-04-09T21:37:23Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj.art-e7a968d23b2c4588832fb3fdc4e466382023-03-26T11:15:07ZengBMCDiabetology & Metabolic Syndrome1758-59962023-03-011511910.1186/s13098-023-01033-wPerirenal fat thickness and liver fat fraction are independent predictors of MetS in adults with overweight and obesity suspected with NAFLD: a retrospective studyLi Wang0Yuning Pan1Xianwang Ye2Yongmeng Zhu3Yandong Lian4Hui Zhang5Miao Xu6Mengxiao Liu7Xinzhong Ruan8Department of Radiology, Ningbo First HospitalDepartment of Radiology, Ningbo First HospitalDepartment of Radiology, Ningbo First HospitalDepartment of Radiology, Ningbo First HospitalDepartment of Radiology, Ningbo First HospitalDepartment of Radiology, Ningbo First HospitalDepartment of Endocrinology, Ningbo First HospitalMR CollaborationsDepartment of Radiology, Ningbo First HospitalAbstract Background Nonalcoholic fatty liver disease (NAFLD) has a multidirectional relationship with metabolic syndrome (MetS) and used to be considered a hepatic manifestation of MetS. Perirenal fat, as a part of visceral adipose tissue (VAT), was reported to be correlated with MetS components, but data for intraorgan fat are lacking. This study was undertaken to assess the value of peripheral and intraorgan fat to predict MetS in adults with overweight and obesity with suspected NAFLD. Methods We studied 134 sequential adults (mean age, 31.5 years; 47% female) with overweight and obesity with suspected NAFLD. All participants underwent abdominal magnetic resonance imaging (MRI) examination. Anthropometric and metabolic parameters and perirenal fat thickness (PRFT), subcutaneous adipose tissue thickness (SATT), liver fat fraction (LFF), pancreas fat fraction (PFF), and lumbar spine fat fraction (LSFF) were collected. MetS was defined according to the International Diabetes Federation (IDF) criteria. Statistical analyses included basic statistics, linear correlation and logistic regression analysis. Results A total of 63 adults with MetS and 71 adults with advanced liver steatosis (grades 2 and 3) were included in our study. Patients with MetS had greater PRFT (p = 0.026) and LFF (p < 0.001), as well as greater homeostasis model assessment of insulin resistance (HOMA-IR), alanine transaminase (ALT), aspartate transaminase (AST), and decreased SATT. MetS patients had a higher proportion of advanced steatosis than those without MetS (P < 0.001). The MetS score was associated with PRFT and LFF. Logistic regression analysis showed that the PRFT and LFF were independent predictors of MetS after adjusting for age and sex. A cutoff of 9.15 mm for PRFT and 14.68% for LFF could be predictive of MetS. Conclusions This study shows that the absolute cutoff level of 9.15 mm for PRFT and 14.68% for LFF may be clinically important markers for identifying patients who are at high risk of MetS among adults with overweight and obesity with suspected NAFLD, irrespective of sex and age. Moreover, ectopic fat levels in pancreas and lumbar spine are positively associated with PRFT. Trial registration Not applicable.https://doi.org/10.1186/s13098-023-01033-wPerirenal fatIntraorgan fatMetabolic syndromeNonalcoholic fatty liver disease |
| spellingShingle | Li Wang Yuning Pan Xianwang Ye Yongmeng Zhu Yandong Lian Hui Zhang Miao Xu Mengxiao Liu Xinzhong Ruan Perirenal fat thickness and liver fat fraction are independent predictors of MetS in adults with overweight and obesity suspected with NAFLD: a retrospective study Diabetology & Metabolic Syndrome Perirenal fat Intraorgan fat Metabolic syndrome Nonalcoholic fatty liver disease |
| title | Perirenal fat thickness and liver fat fraction are independent predictors of MetS in adults with overweight and obesity suspected with NAFLD: a retrospective study |
| title_full | Perirenal fat thickness and liver fat fraction are independent predictors of MetS in adults with overweight and obesity suspected with NAFLD: a retrospective study |
| title_fullStr | Perirenal fat thickness and liver fat fraction are independent predictors of MetS in adults with overweight and obesity suspected with NAFLD: a retrospective study |
| title_full_unstemmed | Perirenal fat thickness and liver fat fraction are independent predictors of MetS in adults with overweight and obesity suspected with NAFLD: a retrospective study |
| title_short | Perirenal fat thickness and liver fat fraction are independent predictors of MetS in adults with overweight and obesity suspected with NAFLD: a retrospective study |
| title_sort | perirenal fat thickness and liver fat fraction are independent predictors of mets in adults with overweight and obesity suspected with nafld a retrospective study |
| topic | Perirenal fat Intraorgan fat Metabolic syndrome Nonalcoholic fatty liver disease |
| url | https://doi.org/10.1186/s13098-023-01033-w |
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